PL445189A1 - Method of obtaining an aqueous extract of Trametes versicolor rich in protein and peptides and the use of the extract of Trametes versicolor to support the prevention and treatment of diseases caused by staphylococci and streptococci - Google Patents

Method of obtaining an aqueous extract of Trametes versicolor rich in protein and peptides and the use of the extract of Trametes versicolor to support the prevention and treatment of diseases caused by staphylococci and streptococci

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Publication number
PL445189A1
PL445189A1 PL445189A PL44518923A PL445189A1 PL 445189 A1 PL445189 A1 PL 445189A1 PL 445189 A PL445189 A PL 445189A PL 44518923 A PL44518923 A PL 44518923A PL 445189 A1 PL445189 A1 PL 445189A1
Authority
PL
Poland
Prior art keywords
extract
trametes versicolor
peptides
rich
staphylococci
Prior art date
Application number
PL445189A
Other languages
Polish (pl)
Other versions
PL247631B1 (en
Inventor
Urszula Kosikowska
Sylwia Andrzejczuk
Dorota Pietras-Ożga
Katarzyna Michalak
Stanisław Winiarczyk
Original Assignee
Uniwersytet Medyczny W Lublinie
Uniwersytet Przyrodniczy W Lublinie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Medyczny W Lublinie, Uniwersytet Przyrodniczy W Lublinie filed Critical Uniwersytet Medyczny W Lublinie
Priority to PL445189A priority Critical patent/PL247631B1/en
Publication of PL445189A1 publication Critical patent/PL445189A1/en
Publication of PL247631B1 publication Critical patent/PL247631B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Fruits And Vegetables (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania ekstraktu z wrośniaka różnobarwnego (Trametes versicolor) bogatego w białka i peptydy, charakteryzuje się tym, że przed ekstrakcją owocniki przygotowuje się w ten sposób, że oczyszczone i podzielone na mniejsze fragmenty mrozi się w temperaturze -20°C do -80°C, po czym zamrożony materiał zalewa się ciekłym azotem korzystnie trzykrotnie i rozciera się na proszek lub alternatywnie poddaje się liofilizacji w temperaturze od -50°C do -40°C, korzystnie -45°C przy ciśnieniu wynoszącym od 4 do 6 Pa, optymalnie 5 Pa, aż do uzyskania stałej masy liofilizatu, następnie zliofilizowane lub rozdrobnione (roztarte) owocniki poddaje się ekstrakcji zalewając wodą w proporcjach w:w od 1:15 do 1:30, korzystnie 1:20, proces prowadzi się w temperaturze od 50°C do 80°C przez 1,5 do 2-ch godzin, po czym chłodzi do temperatury 30°C, odwirowuje supernatant i poddaje koncentracji, korzystnie do uzyskania dziesięciokrotnie zatężonego ekstraktu. Przedmiotem zgłoszenia jest także ekstrakt z wrośniaka różnobarwnego (Trametes versicolor) bogatego w białka i peptydy do zastosowania do wspomagania profilaktyki i leczenia chorób wywoływanych przez gronkowce i paciorkowce.The subject of the application is a method of obtaining an extract from Trametes versicolor rich in proteins and peptides, characterized in that prior to extraction, the fruiting bodies are prepared in such a way that the fruiting bodies, cleaned and divided into smaller fragments, are frozen at a temperature of -20°C to -80°C, after which the frozen material is poured with liquid nitrogen, preferably three times, and ground into a powder or alternatively subjected to lyophilization at a temperature of -50°C to -40°C, preferably -45°C at a pressure of 4 to 6 Pa, optimally 5 Pa, until a constant mass of the lyophilizate is obtained, then the lyophilized or crushed (ground) fruiting bodies are subjected to extraction by pouring water in w:w proportions of 1:15 to 1:30, preferably 1:20, the process is carried out at a temperature of 50°C to 80°C for 1.5 to 2 hours, then cooled to 30°C, the supernatant is centrifuged and concentrated, preferably to obtain a ten-fold concentrated extract. The subject of the application is also an extract of Trametes versicolor rich in proteins and peptides for use in supporting the prevention and treatment of diseases caused by staphylococci and streptococci.

PL445189A 2023-06-12 2023-06-12 Method of preparing an aqueous extract of Trametes versicolor rich in protein and peptides and the use of the extract of Trametes versicolor to support the prevention and treatment of diseases caused by staphylococci and streptococci PL247631B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL445189A PL247631B1 (en) 2023-06-12 2023-06-12 Method of preparing an aqueous extract of Trametes versicolor rich in protein and peptides and the use of the extract of Trametes versicolor to support the prevention and treatment of diseases caused by staphylococci and streptococci

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL445189A PL247631B1 (en) 2023-06-12 2023-06-12 Method of preparing an aqueous extract of Trametes versicolor rich in protein and peptides and the use of the extract of Trametes versicolor to support the prevention and treatment of diseases caused by staphylococci and streptococci

Publications (2)

Publication Number Publication Date
PL445189A1 true PL445189A1 (en) 2024-12-16
PL247631B1 PL247631B1 (en) 2025-08-11

Family

ID=93894978

Family Applications (1)

Application Number Title Priority Date Filing Date
PL445189A PL247631B1 (en) 2023-06-12 2023-06-12 Method of preparing an aqueous extract of Trametes versicolor rich in protein and peptides and the use of the extract of Trametes versicolor to support the prevention and treatment of diseases caused by staphylococci and streptococci

Country Status (1)

Country Link
PL (1) PL247631B1 (en)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
K. SUŁKOWSKA-ZIAJA I INNI, „TRAMETES VERSICOLOR (L.) LLOYD JAKO ŹRÓDŁO ZWIĄZKÓW BIOLOGICZNIE AKTYWNYCH O SZEROKIM SPEKTRUM DZIAŁANIA I ZASTOSOWANIA", BORGIS - POSTĘPY FITOTERAPII 4/2016, S. 274-281 *
MDPI; Zhichen He et al "Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment", Biomedicines 2022, 10, 2841., https://doi.org/10.3390/biomedicines10112841, MDPI *
NIH; Aarti Bains et al. "In vitro bioactivity, antimicrobial and anti-inflammatory efficacy of modified solvent evaporation assisted Trametes versicolor extract", 3 Biotech. 2020 Sep; 10(9): 404., doi: 10.1007/s13205-020-02397-w *
ŞULE İNCİ ET AL., "ANTIOXIDANT AND ANTIMICROBIAL EFFECTS OF TRAMETES VERSICOLOR (L.) LLOYD EXTRACTS IN DIFFERENT SOLVENTS", TURKISH JOURNAL OF SCIENCE & TECHNOLOGY , 17(2), 261-265, 2022, HTTPS://DOI.ORG/10.35234/FUMBD.1076245 *

Also Published As

Publication number Publication date
PL247631B1 (en) 2025-08-11

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