PL445149A1 - Method for producing a dressing insert based on curdlan for medical applications - Google Patents
Method for producing a dressing insert based on curdlan for medical applicationsInfo
- Publication number
- PL445149A1 PL445149A1 PL445149A PL44514923A PL445149A1 PL 445149 A1 PL445149 A1 PL 445149A1 PL 445149 A PL445149 A PL 445149A PL 44514923 A PL44514923 A PL 44514923A PL 445149 A1 PL445149 A1 PL 445149A1
- Authority
- PL
- Poland
- Prior art keywords
- curdlan
- aac
- poly
- acrylic acid
- modified
- Prior art date
Links
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 title abstract 4
- 229920002558 Curdlan Polymers 0.000 title abstract 3
- 239000001879 Curdlan Substances 0.000 title abstract 3
- 229940078035 curdlan Drugs 0.000 title abstract 3
- 235000019316 curdlan Nutrition 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 poly(sodium acrylate) Polymers 0.000 abstract 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000003431 cross linking reagent Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 3
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 abstract 2
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 abstract 1
- KWVGIHKZDCUPEU-UHFFFAOYSA-N 2,2-dimethoxy-2-phenylacetophenone Chemical compound C=1C=CC=CC=1C(OC)(OC)C(=O)C1=CC=CC=C1 KWVGIHKZDCUPEU-UHFFFAOYSA-N 0.000 abstract 1
- KRFFWELOYNJROH-UHFFFAOYSA-N 2-hydroxy-1,2-diphenylethanone Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1.C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 KRFFWELOYNJROH-UHFFFAOYSA-N 0.000 abstract 1
- 229920001503 Glucan Polymers 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 abstract 1
- 239000012965 benzophenone Substances 0.000 abstract 1
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229940047670 sodium acrylate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
Zgłoszenie dotyczy sposobu wytwarzania materiału, gdzie przy użyciu drukarki 3D z funkcją druku pasty (tzw. metoda addytywna), otrzymuje się trójskładnikowy materiał złożony ze zmodyfikowanego β-1 3-glukanu (kurdlanu), usieciowanego kopolimeru poli(akrylanu sodu) z kwasem akrylowym i poliwinylopirolidonu. Sposób polega na tym, że równolegle przygotowuje się dwa składniki w postaci sproszkowanej: kurdlan zmodyfikowany w znany sposób oraz supersorbent na bazie kopolimeru poli(akrylanu sodu) z kwasem akrylowym, gdzie kwas akrylowy poddaje się zobojętnieniu 75 - 95 [%mol] korzystnie 85% mol zasadą sodową (NaOH) w temperaturze do 10°C, po czym do otrzymanego roztworu zawierającego akrylan sodu (NaAc) dodaje się czynnik sieciujący (CA): metakrylan glicydylu (GMA) lub dimetakrylan glikolu etylenowego (EGDMA), przy czym względny stosunek molowy CA:AAc = 1:50 — 1:400, korzystnie 1:100 oraz fotoinicjator (PI): benzofenon, 2-hydroksy-2-fenyloacetofenon (benzoina) lub 2,2-dimetoksy-2-fenyloacetofenon w ilości od 0,1-2% [w/w] początkowej masy AAc, korzystnie 0,5% [w/w] początkowej masy AAc, otrzymaną mieszaninę poddaje się polimeryzacji pod wpływem światła UV i suszy się, po czym otrzymane komponenty zmodyfikowany kurdlan oraz poli(NaAc-co-AAc) dodaje się do alkoholowego roztworu poliwinylopirolidonu (PVP) o stężeniu od 3% do 7% korzystnie 5%, przy czym składniki miesza się w stosunku wagowym od 0,8:0,8:03 do 1,2:1,2:0:8 korzystnie 1:1:0,5 następnie z otrzymanej mieszaniny (pasty) wytwarza się wkład opatrunkowy za pomocą drukarki 3D.The application concerns a method of producing a material where, using a 3D printer with a paste printing function (the so-called additive method), a three-component material is obtained consisting of a modified β-1 3-glucan (curdlan), a cross-linked copolymer of poly(sodium acrylate) with acrylic acid and polyvinylpyrrolidone. The method consists in preparing two components in powdered form in parallel: curdlan modified in a known way and a supersorbent based on a copolymer of poly(sodium acrylate) with acrylic acid, where the acrylic acid is neutralized to 75 - 95 [%mol], preferably 85% mol of sodium base (NaOH) at a temperature of up to 10°C, then a cross-linking agent (CA) is added to the obtained solution containing sodium acrylate (NaAc): glycidyl methacrylate (GMA) or ethylene glycol dimethacrylate (EGDMA), with the relative molar ratio CA:AAc = 1:50 - 1:400, preferably 1:100 and photoinitiator (PI): benzophenone, 2-hydroxy-2-phenylacetophenone (benzoin) or 2,2-dimethoxy-2-phenylacetophenone in an amount of 0.1 -2% [w/w] of the initial mass of AAc, preferably 0.5% [w/w] of the initial mass of AAc, the obtained mixture is polymerized under the influence of UV light and dried, and then the obtained components are modified curdlan and poly(NaAc- co-AAc) is added to an alcoholic solution of polyvinylpyrrolidone (PVP) with a concentration of 3% to 7%, preferably 5%, and the ingredients are mixed in a weight ratio of 0.8:0.8:03 to 1.2:1, 2:0:8, preferably 1:1:0.5, then a dressing insert is produced from the obtained mixture (paste) using a 3D printer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL445149A PL246959B1 (en) | 2023-06-06 | 2023-06-06 | Method of manufacturing a dressing insert based on curdlan for medical applications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL445149A PL246959B1 (en) | 2023-06-06 | 2023-06-06 | Method of manufacturing a dressing insert based on curdlan for medical applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL445149A1 true PL445149A1 (en) | 2024-06-17 |
| PL246959B1 PL246959B1 (en) | 2025-04-07 |
Family
ID=91539479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL445149A PL246959B1 (en) | 2023-06-06 | 2023-06-06 | Method of manufacturing a dressing insert based on curdlan for medical applications |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL246959B1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2512841A (en) * | 2013-04-08 | 2014-10-15 | Brightwake Ltd | Absorbent wound dressings |
| PL236367B1 (en) * | 2019-07-01 | 2021-01-11 | Univ Medyczny W Lublinie | Cryogel wound dressing material based on agarose and method of its production |
| PL430455A1 (en) * | 2019-07-01 | 2021-01-11 | Uniwersytet Medyczny W Lublinie | Chitosan-based cryogel wound dressing material and method of its production |
| PL238256B1 (en) * | 2020-02-06 | 2021-08-02 | Uniwersytet Medyczny W Lublinie | Method of producing an absorbent curdlan-based biomaterial for medical applications |
| EP3585399B1 (en) * | 2017-02-22 | 2022-02-09 | Medid Innovation Development Ltd | Antiseptic composition comprising polyvinylpyrrolidone and unithiol and use of the composition |
-
2023
- 2023-06-06 PL PL445149A patent/PL246959B1/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2512841A (en) * | 2013-04-08 | 2014-10-15 | Brightwake Ltd | Absorbent wound dressings |
| EP3585399B1 (en) * | 2017-02-22 | 2022-02-09 | Medid Innovation Development Ltd | Antiseptic composition comprising polyvinylpyrrolidone and unithiol and use of the composition |
| PL236367B1 (en) * | 2019-07-01 | 2021-01-11 | Univ Medyczny W Lublinie | Cryogel wound dressing material based on agarose and method of its production |
| PL430455A1 (en) * | 2019-07-01 | 2021-01-11 | Uniwersytet Medyczny W Lublinie | Chitosan-based cryogel wound dressing material and method of its production |
| PL238256B1 (en) * | 2020-02-06 | 2021-08-02 | Uniwersytet Medyczny W Lublinie | Method of producing an absorbent curdlan-based biomaterial for medical applications |
Also Published As
| Publication number | Publication date |
|---|---|
| PL246959B1 (en) | 2025-04-07 |
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