PL440921A1 - RNA molecule containing modified 5' end cap analogues, the use of an RNA molecule in the in vitro synthesis of protein or peptide, an RNA molecule for use in medicine, the use of modified cap analogues for RNA capping - Google Patents

RNA molecule containing modified 5' end cap analogues, the use of an RNA molecule in the in vitro synthesis of protein or peptide, an RNA molecule for use in medicine, the use of modified cap analogues for RNA capping

Info

Publication number
PL440921A1
PL440921A1 PL440921A PL44092122A PL440921A1 PL 440921 A1 PL440921 A1 PL 440921A1 PL 440921 A PL440921 A PL 440921A PL 44092122 A PL44092122 A PL 44092122A PL 440921 A1 PL440921 A1 PL 440921A1
Authority
PL
Poland
Prior art keywords
rna molecule
rna
cap analogues
modified
peptide
Prior art date
Application number
PL440921A
Other languages
Polish (pl)
Inventor
Marzena JANKOWSKA-ANYSZKA
Karolina PIECYK
Renata Grzela
Edward Darżynkiewicz
Original Assignee
Uniwersytet Warszawski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Warszawski filed Critical Uniwersytet Warszawski
Priority to PL440921A priority Critical patent/PL440921A1/en
Priority to PCT/IB2023/053793 priority patent/WO2023199261A1/en
Publication of PL440921A1 publication Critical patent/PL440921A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

Abstract

Przedmiotem zgłoszenia jest cząsteczka RNA, która na końcu 5' zawiera związek określony wzorem (II). Zgłoszenie obejmuje również sposób syntezy białka lub peptydu in vitro lub w hodowlach komórkowych, który to sposób obejmuje translację cząsteczki RNA, zastosowanie cząsteczki RNA w medycynie oraz zastosowanie nowych analogów kapu do kapowania.The subject of the application is an RNA molecule which at the 5' end contains a compound defined by the formula (II). The application also covers a method for synthesizing a protein or peptide in vitro or in cell cultures, which method includes the translation of an RNA molecule, the use of an RNA molecule in medicine and the use of new cap analogues for capping.

PL440921A 2022-04-13 2022-04-13 RNA molecule containing modified 5' end cap analogues, the use of an RNA molecule in the in vitro synthesis of protein or peptide, an RNA molecule for use in medicine, the use of modified cap analogues for RNA capping PL440921A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL440921A PL440921A1 (en) 2022-04-13 2022-04-13 RNA molecule containing modified 5' end cap analogues, the use of an RNA molecule in the in vitro synthesis of protein or peptide, an RNA molecule for use in medicine, the use of modified cap analogues for RNA capping
PCT/IB2023/053793 WO2023199261A1 (en) 2022-04-13 2023-04-13 Rna molecule containing modified cap analogs at the 5 ' end, use of rna molecule in in vitro protein or peptide synthesis, rna molecule for use in medicine, and use of modified cap analogs for rna capping

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL440921A PL440921A1 (en) 2022-04-13 2022-04-13 RNA molecule containing modified 5' end cap analogues, the use of an RNA molecule in the in vitro synthesis of protein or peptide, an RNA molecule for use in medicine, the use of modified cap analogues for RNA capping

Publications (1)

Publication Number Publication Date
PL440921A1 true PL440921A1 (en) 2023-10-16

Family

ID=88329119

Family Applications (1)

Application Number Title Priority Date Filing Date
PL440921A PL440921A1 (en) 2022-04-13 2022-04-13 RNA molecule containing modified 5' end cap analogues, the use of an RNA molecule in the in vitro synthesis of protein or peptide, an RNA molecule for use in medicine, the use of modified cap analogues for RNA capping

Country Status (2)

Country Link
PL (1) PL440921A1 (en)
WO (1) WO2023199261A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012222675A1 (en) * 2012-12-10 2014-06-12 Universität Hamburg Agent and method for modifying the 5 'cap of RNA

Also Published As

Publication number Publication date
WO2023199261A1 (en) 2023-10-19

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