PL438501A1 - Composition in the form of a nanoemulsion based on vegetable oil, a multi-phase composition and method for preparing these compositions - Google Patents
Composition in the form of a nanoemulsion based on vegetable oil, a multi-phase composition and method for preparing these compositionsInfo
- Publication number
- PL438501A1 PL438501A1 PL438501A PL43850121A PL438501A1 PL 438501 A1 PL438501 A1 PL 438501A1 PL 438501 A PL438501 A PL 438501A PL 43850121 A PL43850121 A PL 43850121A PL 438501 A1 PL438501 A1 PL 438501A1
- Authority
- PL
- Poland
- Prior art keywords
- mass
- parts
- composition
- vegetable oil
- phase
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Pierwszym przedmiotem wynalazku jest kompozycja w postaci nanoemulsji na bazie oleju roślinnego, charakteryzująca się tym, że zawiera olej roślinny, który stanowi olej rzepakowy, w ilości od 10 do 60 części masowych oleju rzepakowego, od 12 do 20 części masowych poloksameru 188, od 40 do 60 części masowych wody oczyszczonej, od 1 do 12 części masowych Spanu 80, od 5 do 20 części masowych poliolu, od 0,10 do 0,50 części masowych kwasu mlekowego, od 0,5 do 5,0 części masowych klotrimazolu, przy czym krople fazy olejowej mają średnicę hydrodynamiczną od 50 nm do 70 nm. Drugim przedmiotem wynalazku jest kompozycja wielofazowa na bazie nanoemulsji oleju roślinnego, charakteryzująca się tym, że zawiera fazę polisacharydową w ilości od 10 do 50 części masowych i nanoemulsję wg pierwszego przedmiotu wynalazku w ilości od 50 do 90 części masowych, przy czym kompozycja wielofazowa ma postać nanoemulżelu, przy czym kompozycja wielofazowa ma lepkość dynamiczną od 220 mPa•s do 580 mPa•s. Wynalazek obejmuje także sposoby otrzymywania rzeczonych kompozycji.The first object of the invention is a composition in the form of a nanoemulsion based on vegetable oil, characterized in that it contains vegetable oil, which is rapeseed oil, in an amount of 10 to 60 parts by mass of rapeseed oil, 12 to 20 parts by mass of poloxamer 188, 40 to 60 parts by mass of purified water, from 1 to 12 parts by mass of Span 80, from 5 to 20 parts by mass of polyol, from 0.10 to 0.50 parts by mass of lactic acid, from 0.5 to 5.0 parts by mass of clotrimazole, with the oil phase droplets have a hydrodynamic diameter of 50 nm to 70 nm. The second subject of the invention is a multi-phase composition based on vegetable oil nanoemulsion, characterized in that it contains a polysaccharide phase in an amount of 10 to 50 parts by mass and a nanoemulsion according to the first subject of the invention in an amount of 50 to 90 parts by mass, wherein the multi-phase composition is in the form of a nanoemulgel wherein the multiphase composition has a dynamic viscosity of from 220 mPa•s to 580 mPa•s. The invention also includes methods for preparing said compositions.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL438501A PL438501A1 (en) | 2021-07-16 | 2021-07-16 | Composition in the form of a nanoemulsion based on vegetable oil, a multi-phase composition and method for preparing these compositions |
PCT/PL2022/000039 WO2023287309A1 (en) | 2021-07-16 | 2022-07-15 | Pharmaceutical composition in the form of vegetable oil-based nanoemulsion, multiphase composition and method of preparation of these compositions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL438501A PL438501A1 (en) | 2021-07-16 | 2021-07-16 | Composition in the form of a nanoemulsion based on vegetable oil, a multi-phase composition and method for preparing these compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
PL438501A1 true PL438501A1 (en) | 2023-01-23 |
Family
ID=83546936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL438501A PL438501A1 (en) | 2021-07-16 | 2021-07-16 | Composition in the form of a nanoemulsion based on vegetable oil, a multi-phase composition and method for preparing these compositions |
Country Status (2)
Country | Link |
---|---|
PL (1) | PL438501A1 (en) |
WO (1) | WO2023287309A1 (en) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2094688B1 (en) * | 1994-08-08 | 1997-08-01 | Cusi Lab | MANOEMULSION OF THE TYPE OF OIL IN WATER, USEFUL AS AN OPHTHALMIC VEHICLE AND PROCEDURE FOR ITS PREPARATION. |
KR20040028336A (en) * | 2002-09-30 | 2004-04-03 | 김종국 | Novel composite of thermosensitive antifungal gel for vaginal administration |
CN1931163A (en) * | 2006-09-20 | 2007-03-21 | 西北农林科技大学 | Nanometer clotrimazole emulsion medicine and its prepn process |
PL210178B1 (en) * | 2007-06-15 | 2011-12-30 | Politechnika Wroclawska | Production method of emulsion stabilized with surfactants |
CN101909654A (en) * | 2007-11-28 | 2010-12-08 | 联邦科学和工业研究组织 | Nanoemulsions |
DE102008034944B4 (en) * | 2008-07-26 | 2017-03-16 | Arivine Pharma Ag | microemulsion |
DE202014010412U1 (en) * | 2014-02-21 | 2015-09-01 | Ursapharm Arzneimittel Gmbh | Micro or nanoemulsion for ophthalmic application |
CN110664733A (en) * | 2019-10-09 | 2020-01-10 | 华欧研创生物科技(深圳)有限公司 | Hyaluronic acid nanoemulsion gel for nursing female vagina |
-
2021
- 2021-07-16 PL PL438501A patent/PL438501A1/en unknown
-
2022
- 2022-07-15 WO PCT/PL2022/000039 patent/WO2023287309A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2023287309A1 (en) | 2023-01-19 |
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