PL435008A1 - Method of preparing 1-(2'-hydroxyphenyl)-3-(2'-bromophenyl)- -propan-1-one - Google Patents

Method of preparing 1-(2'-hydroxyphenyl)-3-(2'-bromophenyl)- -propan-1-one

Info

Publication number
PL435008A1
PL435008A1 PL435008A PL43500820A PL435008A1 PL 435008 A1 PL435008 A1 PL 435008A1 PL 435008 A PL435008 A PL 435008A PL 43500820 A PL43500820 A PL 43500820A PL 435008 A1 PL435008 A1 PL 435008A1
Authority
PL
Poland
Prior art keywords
bromophenyl
hydroxyphenyl
propan
preparing
organic solvent
Prior art date
Application number
PL435008A
Other languages
Polish (pl)
Other versions
PL245488B1 (en
Inventor
Mateusz Łużny
Dagmara Kaczanowska
Barbara GAWDZIK
Alicja Wzorek
Aleksandra Pawlak
Bożena Obmińska-Mrukowicz
Ewa Kozłowska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Uniwersytet Jana Kochanowskiego W Kielcach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu, Uniwersytet Jana Kochanowskiego W Kielcach filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL435008A priority Critical patent/PL245488B1/en
Publication of PL435008A1 publication Critical patent/PL435008A1/en
Publication of PL245488B1 publication Critical patent/PL245488B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania 1-(2'-hydroksyfenylo)-3-(2"-bromofenylo)-propan-1-onu, charakteryzujący się tym, że do podłoża odpowiedniego dla drożdży wprowadza się szczep Yarrowia lipolytica KCh 71, następnie po upływie co najmniej 48 godzin do hodowli wprowadza się substrat, którym jest 1-(2'-hyrdoksyfenylo)-3-(2"-bromofenylo)-prop-2-en-1-on o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 1 godzinę, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie.The subject of the application is a method for the production of 1- (2'-hydroxyphenyl) -3- (2 "-bromophenyl) -propan-1-one, characterized in that the Yarrowia lipolytica KCh 71 strain is introduced into a medium suitable for yeast, followed by The substrate is introduced to the culture at least 48 hours, which is 1- (2'-hydroxyphenyl) -3- (2 "-bromophenyl) -prop-2-en-1-one of formula 1, dissolved in an organic solvent miscible with water, the transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 1 hour, then the product is extracted with a water-immiscible organic solvent and purified by chromatography.

PL435008A 2020-08-19 2020-08-19 Method of producing 1-(2'-hydroxyphenyl)-3-(2"-bromophenyl)-propan-1-one PL245488B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL435008A PL245488B1 (en) 2020-08-19 2020-08-19 Method of producing 1-(2'-hydroxyphenyl)-3-(2"-bromophenyl)-propan-1-one

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL435008A PL245488B1 (en) 2020-08-19 2020-08-19 Method of producing 1-(2'-hydroxyphenyl)-3-(2"-bromophenyl)-propan-1-one

Publications (2)

Publication Number Publication Date
PL435008A1 true PL435008A1 (en) 2022-02-21
PL245488B1 PL245488B1 (en) 2024-08-12

Family

ID=80492587

Family Applications (1)

Application Number Title Priority Date Filing Date
PL435008A PL245488B1 (en) 2020-08-19 2020-08-19 Method of producing 1-(2'-hydroxyphenyl)-3-(2"-bromophenyl)-propan-1-one

Country Status (1)

Country Link
PL (1) PL245488B1 (en)

Also Published As

Publication number Publication date
PL245488B1 (en) 2024-08-12

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