PL430613A1 - Method of identifying persons with insufficient pharmacological mobilization to obtain HSPC, the human Panx1 gene to be used in the identification of such persons and a kit for identifying such persons - Google Patents

Method of identifying persons with insufficient pharmacological mobilization to obtain HSPC, the human Panx1 gene to be used in the identification of such persons and a kit for identifying such persons

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Publication number
PL430613A1
PL430613A1 PL430613A PL43061319A PL430613A1 PL 430613 A1 PL430613 A1 PL 430613A1 PL 430613 A PL430613 A PL 430613A PL 43061319 A PL43061319 A PL 43061319A PL 430613 A1 PL430613 A1 PL 430613A1
Authority
PL
Poland
Prior art keywords
persons
identifying
panx1
gene
human
Prior art date
Application number
PL430613A
Other languages
Polish (pl)
Other versions
PL240899B1 (en
Inventor
Mariusz Zdzisław Ratajczak
Magdalena Józefa Kucia
Monika Cymer
Marta Libura
Elżbieta Urbanowska
Original Assignee
Warszawski Uniwersytet Medyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warszawski Uniwersytet Medyczny filed Critical Warszawski Uniwersytet Medyczny
Priority to PL430613A priority Critical patent/PL240899B1/en
Publication of PL430613A1 publication Critical patent/PL430613A1/en
Publication of PL240899B1 publication Critical patent/PL240899B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Przedmiotem wynalazku jest sposób identyfikacji osób, których organizm nie poddaje się w wystarczającym stopniu mobilizacji farmakologicznej wykonywanej w celu pozyskiwania krwiotwórczych komórek macierzystych szpiku, przy czym sposób obejmuje etap badania próbki biologicznej od osoby, u której ma być wykonywana wymieniona mobilizacja farmakologiczna pod kątem występowania polimorfizmów w ludzkim genie Panx1, przy czym występowanie polimorfizmu wskazuje na zmienioną zdolność organizmu do poddawania się mobilizacji farmakologicznej wykonywanej w celu pozyskiwania krwiotwórczych komórek macierzystych szpiku. Przedmiotem wynalazku jest również ludzki gen Panx1 do zastosowania w identyfikacji osób, których organizm nie poddaje się w wystarczającym stopniu mobilizacji farmakologicznej wykonywanej w celu pozyskiwania krwiotwórczych komórek macierzystych szpiku oraz zestaw do identyfikacji osób, których organizm nie poddaje się w wystarczającym stopniu mobilizacji farmakologicznej wykonywanej w celu pozyskiwania krwiotwórczych komórek macierzystych szpiku.The subject of the invention is a method of identifying persons whose body is not sufficiently subject to pharmacological mobilization performed to obtain hematopoietic stem cells of the bone marrow, the method comprising the step of testing a biological sample from the person in whom the said pharmacological mobilization is to be performed for the presence of polymorphisms in the bone marrow. the human Panx1 gene, wherein the presence of the polymorphism is indicative of an altered ability of the body to undergo pharmacological mobilization to harvest marrow hematopoietic stem cells. The invention also relates to the human Panx1 gene for use in the identification of individuals whose body is not sufficiently subject to pharmacological mobilization to obtain hematopoietic stem cells of the bone marrow and a kit for identifying individuals whose organism is not sufficiently subjected to pharmacological mobilization for the purpose of obtaining obtaining hematopoietic stem cells from the bone marrow.

PL430613A 2019-07-16 2019-07-16 Method of identifying persons with insufficient pharmacological mobilization to obtain HSPC, the human Panx1 gene to be used in the identification of such persons and a kit for identifying such persons PL240899B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL430613A PL240899B1 (en) 2019-07-16 2019-07-16 Method of identifying persons with insufficient pharmacological mobilization to obtain HSPC, the human Panx1 gene to be used in the identification of such persons and a kit for identifying such persons

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL430613A PL240899B1 (en) 2019-07-16 2019-07-16 Method of identifying persons with insufficient pharmacological mobilization to obtain HSPC, the human Panx1 gene to be used in the identification of such persons and a kit for identifying such persons

Publications (2)

Publication Number Publication Date
PL430613A1 true PL430613A1 (en) 2021-01-25
PL240899B1 PL240899B1 (en) 2022-06-27

Family

ID=74222298

Family Applications (1)

Application Number Title Priority Date Filing Date
PL430613A PL240899B1 (en) 2019-07-16 2019-07-16 Method of identifying persons with insufficient pharmacological mobilization to obtain HSPC, the human Panx1 gene to be used in the identification of such persons and a kit for identifying such persons

Country Status (1)

Country Link
PL (1) PL240899B1 (en)

Also Published As

Publication number Publication date
PL240899B1 (en) 2022-06-27

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