PL427994A1 - Chiral sulfonamide derivatives of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine, method of their preparation, their uses and a pharmaceutical composition containing a chiral sulfonamide derivative of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine - Google Patents

Chiral sulfonamide derivatives of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine, method of their preparation, their uses and a pharmaceutical composition containing a chiral sulfonamide derivative of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine

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Publication number
PL427994A1
PL427994A1 PL427994A PL42799418A PL427994A1 PL 427994 A1 PL427994 A1 PL 427994A1 PL 427994 A PL427994 A PL 427994A PL 42799418 A PL42799418 A PL 42799418A PL 427994 A1 PL427994 A1 PL 427994A1
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PL
Poland
Prior art keywords
tetrazolo
pyrazolo
phenyl
methyl
triazine
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Application number
PL427994A
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Polish (pl)
Other versions
PL237895B1 (en
Inventor
Anna Bielawska
Krzysztof Bielawski
Mariusz Mojzych
Katarzyna Kotwica-Mojzych
Original Assignee
Uniwersytet Medyczny W Białymstoku
Uniwersytet Przyrodniczo-Humanistyczny W Siedlcach
Uniwersytet Medyczny W Lublinie
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Application filed by Uniwersytet Medyczny W Białymstoku, Uniwersytet Przyrodniczo-Humanistyczny W Siedlcach, Uniwersytet Medyczny W Lublinie filed Critical Uniwersytet Medyczny W Białymstoku
Priority to PL427994A priority Critical patent/PL237895B1/en
Publication of PL427994A1 publication Critical patent/PL427994A1/en
Publication of PL237895B1 publication Critical patent/PL237895B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Przedmiotem wynalazku są chiralne pochodne sulfonamidowe 5-fenylo-7-metylo-pirazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazyny przedstawione ogólnym wzorem 1. Związki które wykazują aktywność przeciwnowotworową, cytostatyczną, cytotoksyczną i antyproliferacyjną. Przedmiotem wynalazku jest także sposób wytwarzania chiralnych sulfonamidowych pochodnych 5-fenylo-7-metylo-pirazolo[4,3-e]tetrazolo[4,5-b][1,2,4] triazyny o ogólnym wzorze 1, a także zastosowania takich związków i kompozycja farmaceutyczna je zawierająca.The subject of the invention are chiral sulfonamide derivatives 5-phenyl-7-methyl-pyrazolo [4,3-e] tetrazolo [4,5-b] [1,2,4] triazines represented by the general formula 1. Compounds that show antitumor, cytostatic activity , cytotoxic and antiproliferative. The invention also relates to a process for the preparation of chiral sulfonamide derivatives of 5-phenyl-7-methyl-pyrazolo [4,3-e] tetrazolo [4,5-b] [1,2,4] triazine of the general formula I, as well as the use of such the compounds and a pharmaceutical composition containing them.

PL427994A 2018-11-30 2018-11-30 Chiral sulfonamide derivatives of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine, method of their preparation, their uses and a pharmaceutical composition containing a chiral sulfonamide derivative of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine PL237895B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL427994A PL237895B1 (en) 2018-11-30 2018-11-30 Chiral sulfonamide derivatives of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine, method of their preparation, their uses and a pharmaceutical composition containing a chiral sulfonamide derivative of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL427994A PL237895B1 (en) 2018-11-30 2018-11-30 Chiral sulfonamide derivatives of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine, method of their preparation, their uses and a pharmaceutical composition containing a chiral sulfonamide derivative of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine

Publications (2)

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PL427994A1 true PL427994A1 (en) 2020-06-01
PL237895B1 PL237895B1 (en) 2021-06-14

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PL427994A PL237895B1 (en) 2018-11-30 2018-11-30 Chiral sulfonamide derivatives of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine, method of their preparation, their uses and a pharmaceutical composition containing a chiral sulfonamide derivative of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine

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PL (1) PL237895B1 (en)

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PL237895B1 (en) 2021-06-14

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PL427994A1 (en) Chiral sulfonamide derivatives of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine, method of their preparation, their uses and a pharmaceutical composition containing a chiral sulfonamide derivative of 5-phenyl-7-methyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine