PL424802A1 - Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of myeloma - Google Patents
Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of myelomaInfo
- Publication number
- PL424802A1 PL424802A1 PL424802A PL42480218A PL424802A1 PL 424802 A1 PL424802 A1 PL 424802A1 PL 424802 A PL424802 A PL 424802A PL 42480218 A PL42480218 A PL 42480218A PL 424802 A1 PL424802 A1 PL 424802A1
- Authority
- PL
- Poland
- Prior art keywords
- extract
- cochlospermum
- application
- angolense
- chloroform
- Prior art date
Links
- 241000480100 Cochlospermum angolense Species 0.000 title abstract 3
- 206010035226 Plasma cell myeloma Diseases 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 201000000050 myeloid neoplasm Diseases 0.000 title abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 6
- 238000000605 extraction Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 241000934834 Cochlospermum Species 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000002879 macerating effect Effects 0.000 abstract 1
- 238000002803 maceration Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania ekstraktu z Cochlospermum angolensis (Borututu) polega na tym, że sproszkowaną substancję roślinną Borututu maceruje się chloroformem, korzystnie dwukrotnie, każdorazowo przez 12 - 72 godzin korzystnie 48 godzin, stosując korzystnie ilości najpierw 1:20, a następnie 1:10, po czym macerat chloroformowy lub połączone maceraty odparowuje się w temperaturze nie przekraczającej 40°C i suchą pozostałość (SP) miesza się z żelem krzemionkowym w proporcjach wagowych od 1:1 do 1:100 korzystnie 1:10 i poddaje się dalszej ekstrakcji w układzie ciecz/ciało stałe przy użyciu heksanu lub octanu etylu i/lub ich mieszaniną korzystnie w proporcji 1:1, po czym po odparowaniu eluentu otrzymuje się frakcję o dużej aktywności przeciwnowotworowej. Przedmiotem zgłoszenia jest także ekstrakt z Cochlospermum angolense Welw. ex Oliv. syn. Maximilianea angolensis (Welw. ex Oliv.), otrzymany na drodze dwustopniowej ekstrakcji: maceracji chloroformem oraz ekstrakcji heksanem lub octanem etylu i/lub ich mieszaniną (Ex2) oraz zastosowanie ekstraktu w leczeniu szpiczaka.The subject of the application is a method of obtaining an extract of Cochlospermum angolensis (Borututu), which consists in macerating the powdered plant matter Borututu with chloroform, preferably twice, each time for 12-72 hours, preferably 48 hours, preferably using amounts of first 1:20 and then 1: 10, then the chloroform macerate or the combined macerates are evaporated at a temperature not exceeding 40 ° C and the dry residue (SP) is mixed with silica gel in weight proportions from 1: 1 to 1: 100, preferably 1:10, and further extracted in liquid / solid system using hexane or ethyl acetate and / or a mixture thereof, preferably in the proportion of 1: 1, then, after evaporation of the eluent, a fraction with high antitumor activity is obtained. The subject of the application is also an extract of Cochlospermum angolense Welw. ex Oliv. son. Maximilianea angolensis (Welw. Ex Oliv.), Obtained by two-stage extraction: maceration with chloroform and extraction with hexane or ethyl acetate and / or their mixture (Ex2) and the use of the extract in the treatment of myeloma.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424802A PL237206B1 (en) | 2018-03-08 | 2018-03-08 | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of myeloma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424802A PL237206B1 (en) | 2018-03-08 | 2018-03-08 | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of myeloma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL424802A1 true PL424802A1 (en) | 2019-09-09 |
| PL237206B1 PL237206B1 (en) | 2021-03-22 |
Family
ID=67844677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL424802A PL237206B1 (en) | 2018-03-08 | 2018-03-08 | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of myeloma |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL237206B1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4021428A1 (en) * | 1989-07-14 | 1991-02-28 | Univ Berlin Humboldt | Anthelmintic agent to treat diseases due to worms - contg. carotenoid drug extracted from roots of cochlospermum angolense |
-
2018
- 2018-03-08 PL PL424802A patent/PL237206B1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4021428A1 (en) * | 1989-07-14 | 1991-02-28 | Univ Berlin Humboldt | Anthelmintic agent to treat diseases due to worms - contg. carotenoid drug extracted from roots of cochlospermum angolense |
Non-Patent Citations (3)
| Title |
|---|
| "Pro-apoptyczne właściwości ekstraktów z kory Cochlospermum angolense Welw.", DOCPLAYER.PL, April 2010 (2010-04-01), Retrieved from the Internet <URL:http://docplayer.pl/48011188-Pro-apoptotyczne-wlasciwosci-ekstraktow-z-kory-cochlospermum-angolense-welw.html> * |
| ANGEL JOSABAD ALONSO-CASTRO, MEXICAN MEDICINAL PLANTS USED FOR CANCER TREATMENT: PHARMACOLOGICAL, PHYTOCHEMICAL AND ETHNOBOTANICAL STUDIES, 2011 * |
| REGINALDO VICENTE RIBEIRO, ETHNOBOTANICAL STUDY OF MEDICINAL PLANTS USED BY RIBEIRINHOS IN THE NORD ARAQUAIA MICROREGION * |
Also Published As
| Publication number | Publication date |
|---|---|
| PL237206B1 (en) | 2021-03-22 |
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