PL424419A1 - Method for obtaining bioactive polymer-ceramic composite biomaterial - Google Patents
Method for obtaining bioactive polymer-ceramic composite biomaterialInfo
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- PL424419A1 PL424419A1 PL424419A PL42441918A PL424419A1 PL 424419 A1 PL424419 A1 PL 424419A1 PL 424419 A PL424419 A PL 424419A PL 42441918 A PL42441918 A PL 42441918A PL 424419 A1 PL424419 A1 PL 424419A1
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Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania bioaktywnego biomateriału kompozytowego polimerowo-ceramicznego, zwłaszcza do rekonstrukcji tkanki chrzęstnej, polega na tym, że wodny roztwór polimeru syntetycznego, którym jest poli(winylopirolidon), o stężeniu od 5 do 20% wag., w ilości od 10 do 75% obj. w stosunku do całej kompozycji, łączy się w temperaturze otoczenia, przy ciągłym mieszaniu, z wodnym roztworem polimeru naturalnego, korzystnie żelatyny, o stężeniu od 2 do 10% wag., w ilości od 10 do 75% obj. w stosunku do całej kompozycji, po czym do mieszaniny roztworów wprowadza się, przy ciągłym mieszaniu, fosforan wapnia o strukturze hydroksyapatytu, pochodzenia naturalnego lub syntetycznego, o ziarnach o wielkości poniżej 200 µm, w ilości od 2,5 do 10% wag. kompozycji, uzyskaną mieszaninę poddaje się homogenizacji, następnie do mieszaniny dozuje się, przy ciągłym mieszaniu, czynnik sieciujący, którym jest korzystnie diakrylan poli(glikolu etylenowego) o średniej masie cząsteczkowej wynoszącej 700, w ilości takiej, aby stosunek całkowitej objętości mieszaniny reakcyjnej do objętości dodanego czynnika sieciującego wynosił od 1:0,1 do 1:0,2 oraz fotoinicjator, którym jest 2-hydroksy-2-metylo-propiofenon, w ilości takiej, aby stosunek całkowitej objętości mieszaniny reakcyjnej, uwzględniając objętość czynnika sieciującego, do objętości dodanego fotoinicjatora mieścił się w zakresie od 1 : 0,015 do 1 : 0,300, po czym dokładnie wymieszaną kompozycję poddaje się polimeryzacji w polu promieniowania UV w dawce od 0,2 do 0,8 J/cm2.The subject of the application is a method for obtaining a bioactive polymer-ceramic composite biomaterial, especially for the reconstruction of cartilage tissue, consists in the fact that the aqueous solution of the synthetic polymer, which is poly (vinylpyrrolidone), in a concentration of 5 to 20% by weight, in an amount of 10 to 75% vol relative to the entire composition, is combined at ambient temperature, with constant stirring, with an aqueous solution of natural polymer, preferably gelatin, at a concentration of 2 to 10% by weight, in an amount of 10 to 75% by volume. relative to the entire composition, then calcium phosphate of hydroxyapatite structure, of natural or synthetic origin, with grains smaller than 200 μm, is introduced into the mixture of solutions in an amount of 2.5 to 10% by weight. composition, the resulting mixture is homogenised, then the cross-linking agent is metered into the mixture, which is preferably polyethylene glycol diacrylate with an average molecular weight of 700, in an amount such that the ratio of the total volume of the reaction mixture to the volume added the crosslinking agent was from 1: 0.1 to 1: 0.2 and the photoinitiator, which is 2-hydroxy-2-methyl-propiophenone, in an amount such that the ratio of the total volume of the reaction mixture, taking into account the volume of the crosslinking agent, to the volume of added photoinitiator it ranged from 1: 0.015 to 1: 0.300, after which the thoroughly mixed composition is subjected to polymerization in a UV field at a dose of 0.2 to 0.8 J / cm2.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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PL424419A PL235354B1 (en) | 2018-01-30 | 2018-01-30 | Method for obtaining bioactive polymer-ceramic composite biomaterial |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PL424419A PL235354B1 (en) | 2018-01-30 | 2018-01-30 | Method for obtaining bioactive polymer-ceramic composite biomaterial |
Publications (2)
Publication Number | Publication Date |
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PL424419A1 true PL424419A1 (en) | 2019-08-12 |
PL235354B1 PL235354B1 (en) | 2020-06-29 |
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PL424419A PL235354B1 (en) | 2018-01-30 | 2018-01-30 | Method for obtaining bioactive polymer-ceramic composite biomaterial |
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PL (1) | PL235354B1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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PL442978A1 (en) * | 2022-11-29 | 2024-06-03 | Politechnika Krakowska im. Tadeusza Kościuszki | Method for obtaining a composite with a polymer matrix containing hydroxyapatite and composite with a polymer matrix containing hydroxyapatite |
PL442979A1 (en) * | 2022-11-29 | 2024-06-03 | Politechnika Krakowska im. Tadeusza Kościuszki | Method of obtaining a two-layer bioactive composite coating and two-layer bioactive composite coating |
PL442980A1 (en) * | 2022-11-29 | 2024-06-03 | Politechnika Krakowska im. Tadeusza Kościuszki | Method of obtaining a bioactive composite and bioactive composite |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101584887A (en) * | 2008-07-31 | 2009-11-25 | 华南理工大学 | HA/chitosan/PVP semi-interpenetrating polymer network frame preparing method |
CN101612419A (en) * | 2008-07-31 | 2009-12-30 | 华南理工大学 | The preparation method of HA/ collagen/PVP semi-interpenetrating polymer network frame |
CN106222723A (en) * | 2016-08-17 | 2016-12-14 | 林春梅 | A kind of implant composite biological coatings and preparation technology thereof |
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2018
- 2018-01-30 PL PL424419A patent/PL235354B1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101584887A (en) * | 2008-07-31 | 2009-11-25 | 华南理工大学 | HA/chitosan/PVP semi-interpenetrating polymer network frame preparing method |
CN101612419A (en) * | 2008-07-31 | 2009-12-30 | 华南理工大学 | The preparation method of HA/ collagen/PVP semi-interpenetrating polymer network frame |
CN106222723A (en) * | 2016-08-17 | 2016-12-14 | 林春梅 | A kind of implant composite biological coatings and preparation technology thereof |
Non-Patent Citations (1)
Title |
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HASNAIN M SAQUIB, ALGINATE-BASED BIPOLYMERIC-NANOBIOCERAMIC COMPOSITE MATRICES FOR SUSTAINED DRUG RELEASE, 2016 * |
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Publication number | Publication date |
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PL235354B1 (en) | 2020-06-29 |
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