PL422342A1 - Triazolo-quinoline derivatives of cinchona-tree alkaloids, method for obtaining them and their application - Google Patents
Triazolo-quinoline derivatives of cinchona-tree alkaloids, method for obtaining them and their applicationInfo
- Publication number
- PL422342A1 PL422342A1 PL422342A PL42234217A PL422342A1 PL 422342 A1 PL422342 A1 PL 422342A1 PL 422342 A PL422342 A PL 422342A PL 42234217 A PL42234217 A PL 42234217A PL 422342 A1 PL422342 A1 PL 422342A1
- Authority
- PL
- Poland
- Prior art keywords
- quinoline derivatives
- triazole
- application
- cinchona
- triazolo
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- FGLRGMVWMQLOCO-UHFFFAOYSA-N 2h-triazolo[4,5-h]quinoline Chemical class C1=CC2=CC=CN=C2C2=C1N=NN2 FGLRGMVWMQLOCO-UHFFFAOYSA-N 0.000 title 1
- 235000001258 Cinchona calisaya Nutrition 0.000 abstract 3
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Natural products C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 abstract 3
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 abstract 3
- 229960000948 quinine Drugs 0.000 abstract 3
- RHJBUGCUCCABIG-UHFFFAOYSA-N quinoline;2h-triazole Chemical class C1=CNN=N1.N1=CC=CC2=CC=CC=C21 RHJBUGCUCCABIG-UHFFFAOYSA-N 0.000 abstract 3
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 abstract 1
- DFDGWBQLFOBSNB-UHFFFAOYSA-N 2-(2h-triazol-4-yl)quinoline Chemical compound N1N=NC(C=2N=C3C=CC=CC3=CC=2)=C1 DFDGWBQLFOBSNB-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229910052739 hydrogen Chemical group 0.000 abstract 1
- 239000001257 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 210000005075 mammary gland Anatomy 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia są triazolo-chinolinowe pochodne alkaloidów drzewa chinowego, zawierające ugrupowanie 1,2,3-triazolu w pozycji C-2' lub C-6' przedstawione odpowiednio wzorem ogólnym 1 lub wzorem ogólnym 2, w których R oznacza grupę hydroksylową lub wodór oraz triazolo-chinolinowe pochodne alkaloidów drzewa chinowego, zawierające ugrupowanie 4-(chinolin-2-ylo)-1,2,3-triazolu w pozycji C-9, przedstawione wzorem ogólnym 3. Zgłoszenie dotyczy również sposobów wytwarzania triazolo-chinolinowych pochodnych alkaloidów drzewa chinowego oraz ich zastosowania jako środków przeciwnowotworowych przeznaczonych zwłaszcza do leczenia nowotworów jelita grubego, gruczołu sutkowego, płuc, prostaty oraz powikłań wynikających z ich przerzutownia.The subject of the application are triazole-quinoline derivatives of quinine alkaloids containing 1,2,3-triazole in the C-2 'or C-6' position represented by general formula 1 or general formula 2, respectively, wherein R is a hydroxyl group or hydrogen and triazole-quinoline derivatives of quinine alkaloids containing 4- (quinolin-2-yl) -1,2,3-triazole at the C-9 position, represented by the general formula 3. The application also relates to methods for the preparation of triazole-quinoline derivatives of quinine alkaloids and their use as antineoplastic agents intended especially for the treatment of colorectal, mammary gland, lung, prostate and complications resulting from their metastasis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL422342A PL236095B1 (en) | 2017-07-25 | 2017-07-25 | Triazolo-quinoline derivatives of cinchona-tree alkaloids, method for obtaining them and their application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL422342A PL236095B1 (en) | 2017-07-25 | 2017-07-25 | Triazolo-quinoline derivatives of cinchona-tree alkaloids, method for obtaining them and their application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL422342A1 true PL422342A1 (en) | 2018-02-12 |
| PL236095B1 PL236095B1 (en) | 2020-11-30 |
Family
ID=61148593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL422342A PL236095B1 (en) | 2017-07-25 | 2017-07-25 | Triazolo-quinoline derivatives of cinchona-tree alkaloids, method for obtaining them and their application |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL236095B1 (en) |
-
2017
- 2017-07-25 PL PL422342A patent/PL236095B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL236095B1 (en) | 2020-11-30 |
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