PL422237A1 - Derivative of thiophene and method for obtaining it - Google Patents
Derivative of thiophene and method for obtaining itInfo
- Publication number
- PL422237A1 PL422237A1 PL422237A PL42223717A PL422237A1 PL 422237 A1 PL422237 A1 PL 422237A1 PL 422237 A PL422237 A PL 422237A PL 42223717 A PL42223717 A PL 42223717A PL 422237 A1 PL422237 A1 PL 422237A1
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- environment
- reaction
- subjected
- reduction
- isolation
- Prior art date
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Przedmiotem zgłoszenia jest nowy związek, pochodna tiofenu, którą stanowi octan 3-(5-butylo-3-metylotiofen-2-ylo)-1-metylopropylu o wzorze 1. Zgłoszenie dotyczy także sposobu otrzymywania tego związku, który polega na tym, że 4-(3-metylotiofen-2-ylo)-butan-2-on poddaje się reakcji redukcji borowodorkiem sodu w środowisku metanolu, otrzymany w tej reakcji 4-(3-metylo-tiofen-2-ylo)-butan-2-ol, po wyodrębnieniu ze środowiska reakcji, poddaje się reakcji alkilowania metylowinyloketonem w obecności eteratu trifluorku boru w środowisku dichlorometanu, po czym otrzymany w tej reakcji 4-[3-metylo-5-(3-okso-butylo)tiofen-2-ylo]-butan-2-ol, po wyodrębnieniu ze środowiska reakcji, poddaje się redukcji roztworem wodnym hydrazyny w obecności wodorotlenku potasu w środowisku glikolu propylenowego, produkt redukcji, po oddestylowaniu nadmiaru wody i hydrazyny, oraz wydzieleniu się azotu, wyodrębnia się ze środowiska redukcji i poddaje estryfikacji bezwodnikiem octowym w obecności pirydyny w środowisku dichlorometanu, a produkt estryfikacji, po wyodrębnieniu ze środowiska, oczyszcza się chromatograficznie.The subject of the application is a new compound, a thiophene derivative, which is 3- (5-butyl-3-methylthiophen-2-yl) -1-methylpropyl acetate of formula 1. The application also relates to a method of obtaining this compound, which consists in that - (3-methylthiophen-2-yl) -butan-2-one is subjected to a reduction reaction with sodium borohydride in a methanol medium, obtained in this reaction 4- (3-methyl-thiophen-2-yl) -butan-2-ol, after isolation from the reaction medium, it is subjected to an alkylation reaction with methyl vinyl ketone in the presence of boron trifluoride etherate in a dichloromethane environment, followed by the 4- [3-methyl-5- (3-oxo-butyl) thiophen-2-yl] butane obtained in this reaction -2-ol, after isolation from the reaction medium, is subjected to reduction with an aqueous solution of hydrazine in the presence of potassium hydroxide in a propylene glycol environment, the reduction product, after distilling off the excess water and hydrazine, and the evolution of nitrogen, is extracted from the reduction environment and subjected to anhydrification with anhydride vinegar in the present of pyridine in a dichloromethane environment, and the esterification product, after isolation from the environment, is purified by chromatography.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL422237A PL236430B1 (en) | 2017-07-17 | 2017-07-17 | Derivative of thiophene and method for obtaining it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL422237A PL236430B1 (en) | 2017-07-17 | 2017-07-17 | Derivative of thiophene and method for obtaining it |
Publications (2)
Publication Number | Publication Date |
---|---|
PL422237A1 true PL422237A1 (en) | 2019-01-28 |
PL236430B1 PL236430B1 (en) | 2021-01-11 |
Family
ID=65033980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL422237A PL236430B1 (en) | 2017-07-17 | 2017-07-17 | Derivative of thiophene and method for obtaining it |
Country Status (1)
Country | Link |
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PL (1) | PL236430B1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003053953A1 (en) * | 2001-12-19 | 2003-07-03 | Flexitral Inc. | Thiophene derivatives and their use as fragrants |
PL412803A1 (en) * | 2015-06-22 | 2017-01-02 | Politechnika Łódzka | Derivative of thiophene and method for obtaining it |
-
2017
- 2017-07-17 PL PL422237A patent/PL236430B1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003053953A1 (en) * | 2001-12-19 | 2003-07-03 | Flexitral Inc. | Thiophene derivatives and their use as fragrants |
PL412803A1 (en) * | 2015-06-22 | 2017-01-02 | Politechnika Łódzka | Derivative of thiophene and method for obtaining it |
Also Published As
Publication number | Publication date |
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PL236430B1 (en) | 2021-01-11 |
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