PL422237A1 - Derivative of thiophene and method for obtaining it - Google Patents

Derivative of thiophene and method for obtaining it

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Publication number
PL422237A1
PL422237A1 PL422237A PL42223717A PL422237A1 PL 422237 A1 PL422237 A1 PL 422237A1 PL 422237 A PL422237 A PL 422237A PL 42223717 A PL42223717 A PL 42223717A PL 422237 A1 PL422237 A1 PL 422237A1
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PL
Poland
Prior art keywords
environment
reaction
subjected
reduction
isolation
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Application number
PL422237A
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Polish (pl)
Other versions
PL236430B1 (en
Inventor
Józef Kula
Bartłomiej Kost
Radosław Bonikowski
Sylwia Matysiak
Original Assignee
Politechnika Łódzka
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Application filed by Politechnika Łódzka filed Critical Politechnika Łódzka
Priority to PL422237A priority Critical patent/PL236430B1/en
Publication of PL422237A1 publication Critical patent/PL422237A1/en
Publication of PL236430B1 publication Critical patent/PL236430B1/en

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Przedmiotem zgłoszenia jest nowy związek, pochodna tiofenu, którą stanowi octan 3-(5-butylo-3-metylotiofen-2-ylo)-1-metylopropylu o wzorze 1. Zgłoszenie dotyczy także sposobu otrzymywania tego związku, który polega na tym, że 4-(3-metylotiofen-2-ylo)-butan-2-on poddaje się reakcji redukcji borowodorkiem sodu w środowisku metanolu, otrzymany w tej reakcji 4-(3-metylo-tiofen-2-ylo)-butan-2-ol, po wyodrębnieniu ze środowiska reakcji, poddaje się reakcji alkilowania metylowinyloketonem w obecności eteratu trifluorku boru w środowisku dichlorometanu, po czym otrzymany w tej reakcji 4-[3-metylo-5-(3-okso-butylo)tiofen-2-ylo]-butan-2-ol, po wyodrębnieniu ze środowiska reakcji, poddaje się redukcji roztworem wodnym hydrazyny w obecności wodorotlenku potasu w środowisku glikolu propylenowego, produkt redukcji, po oddestylowaniu nadmiaru wody i hydrazyny, oraz wydzieleniu się azotu, wyodrębnia się ze środowiska redukcji i poddaje estryfikacji bezwodnikiem octowym w obecności pirydyny w środowisku dichlorometanu, a produkt estryfikacji, po wyodrębnieniu ze środowiska, oczyszcza się chromatograficznie.The subject of the application is a new compound, a thiophene derivative, which is 3- (5-butyl-3-methylthiophen-2-yl) -1-methylpropyl acetate of formula 1. The application also relates to a method of obtaining this compound, which consists in that - (3-methylthiophen-2-yl) -butan-2-one is subjected to a reduction reaction with sodium borohydride in a methanol medium, obtained in this reaction 4- (3-methyl-thiophen-2-yl) -butan-2-ol, after isolation from the reaction medium, it is subjected to an alkylation reaction with methyl vinyl ketone in the presence of boron trifluoride etherate in a dichloromethane environment, followed by the 4- [3-methyl-5- (3-oxo-butyl) thiophen-2-yl] butane obtained in this reaction -2-ol, after isolation from the reaction medium, is subjected to reduction with an aqueous solution of hydrazine in the presence of potassium hydroxide in a propylene glycol environment, the reduction product, after distilling off the excess water and hydrazine, and the evolution of nitrogen, is extracted from the reduction environment and subjected to anhydrification with anhydride vinegar in the present of pyridine in a dichloromethane environment, and the esterification product, after isolation from the environment, is purified by chromatography.

PL422237A 2017-07-17 2017-07-17 Derivative of thiophene and method for obtaining it PL236430B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL422237A PL236430B1 (en) 2017-07-17 2017-07-17 Derivative of thiophene and method for obtaining it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL422237A PL236430B1 (en) 2017-07-17 2017-07-17 Derivative of thiophene and method for obtaining it

Publications (2)

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PL422237A1 true PL422237A1 (en) 2019-01-28
PL236430B1 PL236430B1 (en) 2021-01-11

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Application Number Title Priority Date Filing Date
PL422237A PL236430B1 (en) 2017-07-17 2017-07-17 Derivative of thiophene and method for obtaining it

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PL (1) PL236430B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003053953A1 (en) * 2001-12-19 2003-07-03 Flexitral Inc. Thiophene derivatives and their use as fragrants
PL412803A1 (en) * 2015-06-22 2017-01-02 Politechnika Łódzka Derivative of thiophene and method for obtaining it

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003053953A1 (en) * 2001-12-19 2003-07-03 Flexitral Inc. Thiophene derivatives and their use as fragrants
PL412803A1 (en) * 2015-06-22 2017-01-02 Politechnika Łódzka Derivative of thiophene and method for obtaining it

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Publication number Publication date
PL236430B1 (en) 2021-01-11

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