PL421047A1 - 7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oxime - Google Patents
7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oximeInfo
- Publication number
- PL421047A1 PL421047A1 PL421047A PL42104717A PL421047A1 PL 421047 A1 PL421047 A1 PL 421047A1 PL 421047 A PL421047 A PL 421047A PL 42104717 A PL42104717 A PL 42104717A PL 421047 A1 PL421047 A1 PL 421047A1
- Authority
- PL
- Poland
- Prior art keywords
- oxime
- didodecanoxy
- naringenin
- obtaining
- didodecanoxynaringenin
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Przedmiotem zgłoszenia jest oksym 7,4'-didodekanoksynaringeniny o wzorze 2 oraz sposób otrzymywania tego związku. Sposób ten polega na tym, że do substratu, którym jest 7,4'-didodekanoksynaringenina o wzorze 1 dodaje się, chlorowodorek hydroksyloaminy oraz bezwodny octan sodu w stosunku molowym co najmniej 1:1,5:1,5 oraz minimalną ilość mieszaniny alkoholu i chloroformu, co stanowi mieszaninę reakcyjną, którą zabezpiecza się przed dostępem światła i pozostawia w temperaturze od 45°C do 55°C na okres od 24 do 96 godzin przy ciągłym mieszaniu, po czym mieszaninę wylewa się do wody z lodem, a następnie prowadzi się ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą, osusza bezwodnym siarczanem magnezu i/lub bezwodnym siarczanem sodu, a rozpuszczalnik odparowuje się, następnie otrzymany ekstrakt oczyszcza się na kolumnie chromatograficznej.The subject of the application is 7,4'-didodecanoxynaringenin oxime of formula 2 and the method of obtaining this compound. The method consists in adding hydroxylamine hydrochloride and anhydrous sodium acetate in a molar ratio of at least 1: 1.5: 1.5 to a substrate which is 7,4'-didodecanoxynaringenin of formula 1 and a minimum amount of alcohol mixture chloroform, which is a reaction mixture that is protected from light and left at a temperature of 45 ° C to 55 ° C for 24 to 96 hours with continuous stirring, after which the mixture is poured into ice water, followed by extraction with a water-immiscible organic solvent, dried over anhydrous magnesium sulfate and / or anhydrous sodium sulfate, and the solvent is evaporated, then the obtained extract is purified by column chromatography.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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PL421047A PL236848B1 (en) | 2017-03-29 | 2017-03-29 | 7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oxime |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PL421047A PL236848B1 (en) | 2017-03-29 | 2017-03-29 | 7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oxime |
Publications (2)
Publication Number | Publication Date |
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PL421047A1 true PL421047A1 (en) | 2018-10-08 |
PL236848B1 PL236848B1 (en) | 2021-02-22 |
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Family Applications (1)
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PL421047A PL236848B1 (en) | 2017-03-29 | 2017-03-29 | 7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oxime |
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PL (1) | PL236848B1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL443473A1 (en) * | 2023-01-13 | 2024-07-15 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-di-O-heptylnaringenin oxime and method of obtaining 7,4'-di-O-heptylnaringenin oxime |
PL443475A1 (en) * | 2023-01-13 | 2024-07-15 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-di-O-octylnaringenin oxime and method of obtaining 7,4'-di-O-octylnaringenin oxime |
PL443474A1 (en) * | 2023-01-13 | 2024-07-15 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-di-O-nonylnaringenin oxime and method of obtaining 7,4'-di-O-nonylnaringenin oxime |
-
2017
- 2017-03-29 PL PL421047A patent/PL236848B1/en unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL443473A1 (en) * | 2023-01-13 | 2024-07-15 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-di-O-heptylnaringenin oxime and method of obtaining 7,4'-di-O-heptylnaringenin oxime |
PL443475A1 (en) * | 2023-01-13 | 2024-07-15 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-di-O-octylnaringenin oxime and method of obtaining 7,4'-di-O-octylnaringenin oxime |
PL443474A1 (en) * | 2023-01-13 | 2024-07-15 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-di-O-nonylnaringenin oxime and method of obtaining 7,4'-di-O-nonylnaringenin oxime |
Also Published As
Publication number | Publication date |
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PL236848B1 (en) | 2021-02-22 |
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