PL419802A1 - [(1R,4R,6S)-3-Ethenyl-4,7,7-trimethylbicyclo[4.1.0]hept-3-ylo]acetate ethyl and method for producing it - Google Patents
[(1R,4R,6S)-3-Ethenyl-4,7,7-trimethylbicyclo[4.1.0]hept-3-ylo]acetate ethyl and method for producing itInfo
- Publication number
- PL419802A1 PL419802A1 PL419802A PL41980216A PL419802A1 PL 419802 A1 PL419802 A1 PL 419802A1 PL 419802 A PL419802 A PL 419802A PL 41980216 A PL41980216 A PL 41980216A PL 419802 A1 PL419802 A1 PL 419802A1
- Authority
- PL
- Poland
- Prior art keywords
- hept
- trimethylbicyclo
- ethenyl
- producing
- ylo
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- MIMBGJCYGFZNNE-UFGTWUAFSA-N (2E)-2-[(1R,4R,6S)-4,7,7-trimethyl-3-bicyclo[4.1.0]heptanylidene]ethanol Chemical compound C[C@H]1\C(\C[C@H]2C([C@H]2C1)(C)C)=C\CO MIMBGJCYGFZNNE-UFGTWUAFSA-N 0.000 abstract 1
- NDQXKKFRNOPRDW-UHFFFAOYSA-N 1,1,1-triethoxyethane Chemical compound CCOC(C)(OCC)OCC NDQXKKFRNOPRDW-UHFFFAOYSA-N 0.000 abstract 1
- 238000005821 Claisen rearrangement reaction Methods 0.000 abstract 1
- -1 [(1R, 4R , 6S) -3-ethenyl-4,7,7-trimethylbicyclo [4.1.0] hept-3-yl] acetate Chemical compound 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000004809 thin layer chromatography Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Zgłoszenie dotyczy [(1R,4R,6S)-3-etenylo-4,7,7-trimetylobicyklo[4.1.0]hept-3-ylo]octanem etylu, o wzorze 1. Zgłoszenie zawiera też sposób wytwarzania [(1R,4R,6S)-3-etenylo-4,7,7-trimetylobicyklo[4.1.0]hept-3-ylo]octanu etylu o wzorze 1 znamienny tym, (2E)-2-[(1R,4R,6S)-4,7,7-trimetylobicyklo[4.1.0]hept-3-ylideno]etanol poddaje się reakcji przegrupowania Claisena, przy czym reakcję prowadzi się w koszu grzejnym w temperaturze 137°C, a przebieg reakcji kontroluje się za pomocą chromatografii cienkowarstwowej, a po zakończeniu procesu oddestylowuje się nadmiar ortooctanu etylu, a produkt oczyszcza się za pomocą chromatografii kolumnowej.The application relates to [(1R, 4R, 6S) -3-ethenyl-4,7,7-trimethyl-bicyclo [4.1.0] hept-3-yl] with ethyl acetate, of formula 1. The application also contains a method for producing [(1R, 4R , 6S) -3-ethenyl-4,7,7-trimethylbicyclo [4.1.0] hept-3-yl] acetate of formula 1 characterized by (2E) -2 - [(1R, 4R, 6S) -4 , 7,7-trimethylbicyclo [4.1.0] hept-3-ylidene] ethanol is subjected to a Claisen rearrangement reaction, the reaction is carried out in a heating basket at 137 ° C, and the course of the reaction is controlled by thin layer chromatography, and then at the end of the process, excess ethyl orthoacetate is distilled off and the product is purified by column chromatography.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL419802A PL230279B1 (en) | 2016-12-14 | 2016-12-14 | [(1R,4R,6S)-3-Ethenyl-4,7,7-trimethylbicyclo[4.1.0]hept-3-ylo]acetate ethyl and method for producing it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL419802A PL230279B1 (en) | 2016-12-14 | 2016-12-14 | [(1R,4R,6S)-3-Ethenyl-4,7,7-trimethylbicyclo[4.1.0]hept-3-ylo]acetate ethyl and method for producing it |
Publications (2)
Publication Number | Publication Date |
---|---|
PL419802A1 true PL419802A1 (en) | 2018-01-03 |
PL230279B1 PL230279B1 (en) | 2018-10-31 |
Family
ID=60787937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL419802A PL230279B1 (en) | 2016-12-14 | 2016-12-14 | [(1R,4R,6S)-3-Ethenyl-4,7,7-trimethylbicyclo[4.1.0]hept-3-ylo]acetate ethyl and method for producing it |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL230279B1 (en) |
-
2016
- 2016-12-14 PL PL419802A patent/PL230279B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL230279B1 (en) | 2018-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA202090917A1 (en) | OBTAINING PSILOCYBIN, DIFFERENT POLYMORPHOUS FORMS, INTERMEDIATE COMPOUNDS, COMPOSITIONS AND THEIR APPLICATION | |
MX2019009687A (en) | Processes for the preparation of benzodiazepine derivatives. | |
MX2020003458A (en) | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyrid in-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof. | |
BR112016012734A8 (en) | composed of 2-amino-6-fluoro-n- [5-fluoro-pyridin-3-yl] pyrazol [1,5-a] pyrimidin-3-carboxamide, solid forms, composition, use and process for the preparation of said compound | |
PH12015502459B1 (en) | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof | |
CR20160222U (en) | SOLID FORMS OF ACID {[- (3- CHLOROPHENYL) -3- HYDROXIPIRIDIN -2-CARBONIL] AMINO} ACETIC, COMPOSITIONS, AND USES OF THE SAME | |
PL3524609T3 (en) | Process for the preparation of 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivatives, optical isomers thereof, and intermediates of the process | |
CR20200554A (en) | Substituted dihydropyrazolo pyrazine carboxamide derivatives | |
EA201891769A1 (en) | METHOD OF OBTAINING A COMPOUND OF PYRROLO [3,2-d] PYRIMIDINE AND INTERMEDIATE COMPOUNDS | |
ES2709298A1 (en) | PROCEDURE FOR PREPARING ACID METHYL ESTERTER 3 - [(4S) -8-BROMO-1-METHYL-6- (PYRIDIN-2-IL) -4H-IMIDAZO [1,2-A] [1,4] BENZODIAZEPIN-4 -IL] -PROPIONIC, AND USEFUL COMPOUNDS IN THAT PROCEDURE (Machine-translation by Google Translate, not legally binding) | |
UY35746A (en) | SUBSTITUTED PHENYLALANINE DERIVATIVES | |
WO2015120111A3 (en) | Expedient synthesis of sitagliptin | |
EA201891430A1 (en) | SOLID FORMS OF SUBSTITUTED 5,6-DIHYDRO-6-PHENILBENZO [F] IZOHINOLIN-2-AMINE COMPOUNDS | |
BR112018004347A2 (en) | pyrazolo [1,5-a] pyrimidine-3-carboxyamide cyclic ether derivatives | |
TWI799441B (en) | Chromatography carrier, ligand-immobilized carrier, chromatography column, purification method of target substance, and production method of chromatography carrier | |
PL419802A1 (en) | [(1R,4R,6S)-3-Ethenyl-4,7,7-trimethylbicyclo[4.1.0]hept-3-ylo]acetate ethyl and method for producing it | |
MX2019014272A (en) | Ergoline derivatives for use in medicine. | |
EA201990362A1 (en) | ANALOGUE OF VORTIOXETINE AND ITS APPLICATION AND OBTAINING | |
DK2016064T3 (en) | Methods for preparing pyrazole-containing compounds | |
PL419801A1 (en) | (1R,4R,6S)-2'-(Bromomethyl)-4,7,7-trimethylspiro[bicyclo[4.1.0]heptane-3,3'-furane]-5'(4'H)-one and method for producing it | |
BR112022011516A2 (en) | SOLID FORMS OF 2-[3-[4-AMINO-3-(2-FLUORINE-4-PHENOXY-PHENYL)PYRAZOLE[3,4-D]PYRIMIDIN-1-YL]PIPERIDINE-1-CARBONYL]-4-METHYL -4-[4-(OXETAN-3-IL)PIPERAZIN-1-IL]PENT-2-ENENITRILE | |
WO2015188243A9 (en) | PROCESS FOR PREPARING IMATINIB AND IMATINIB MESYLATE NON-NEEDLE SHAPED α2 FORM | |
PL419803A1 (en) | (2E)-2-[(1R,4R,6S)-4,7,7-Trimethylbicyclo[4.1.0]hept-3-ylidene]ethanol and method for producing it | |
DK3864016T3 (en) | PROCESS FOR THE PRODUCTION OF SUBSTITUTED IMIDAZOLE DERIVATIVES | |
PL423669A1 (en) | Ethyl (2E)-2-[(2S,5R)-5-methyl-2-(propan-2-yl)cyclohexylidene]butanoate and method for producing it |