PL413603A1 - Method for producing three-dimensional polylactide scaffolds - Google Patents
Method for producing three-dimensional polylactide scaffoldsInfo
- Publication number
- PL413603A1 PL413603A1 PL413603A PL41360315A PL413603A1 PL 413603 A1 PL413603 A1 PL 413603A1 PL 413603 A PL413603 A PL 413603A PL 41360315 A PL41360315 A PL 41360315A PL 413603 A1 PL413603 A1 PL 413603A1
- Authority
- PL
- Poland
- Prior art keywords
- solution
- polylactide
- dimensional
- producing
- until
- Prior art date
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- Processes Of Treating Macromolecular Substances (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Abstract
Sposób wytwarzania trójwymiarowych rusztowań polilaktydowych do hodowli ekwiwalentów skóry charakteryzuje się tym, że roztwór polilaktydu w chloroformie lub dichlorometanie o stężeniu 4 - 10% wag. umieszcza się w reaktorze szklanym i miesza się do całkowitego rozpuszczenia polimeru. Następnie do roztworu dodaje się nierozpuszczalnik polilaktydu, którym jest alkohol metylowy lub etylowy w ilości od 3 do 20% wag., i miesza się w temperaturze od 20 do 25°C do uzyskania jednorodnego roztworu, po czym dodaje się alkohol alifatyczny C3-C5, prosty lub rozgałęziony, w ilości od 3 do 12% wag. i nadal miesza się do uzyskania jednorodnego roztworu. Roztwór wylewa się na podłoże i suszy. Podczas całego procesu mieszanie realizuje się za pomocą mieszadła o objętości 40 - 50% objętości roztworu polimeru i z prędkością 550 - 700 obr/min.The method of producing three-dimensional polylactide scaffolds for growing skin equivalents is characterized by the fact that a solution of polylactide in chloroform or dichloromethane at a concentration of 4 - 10 wt. placed in a glass reactor and mixed until the polymer is completely dissolved. Next, a polylactide non-solvent, which is methyl or ethyl alcohol, is added to the solution in an amount of 3 to 20% by weight, and stirred at a temperature of 20 to 25 ° C until a homogeneous solution is obtained, followed by addition of a C3-C5 aliphatic alcohol, straight or branched, in an amount of from 3 to 12% by weight and continue to mix until a homogeneous solution is obtained. The solution is poured onto a substrate and dried. During the whole process, mixing is carried out by means of a mixer with a volume of 40 - 50% of the volume of the polymer solution and at a speed of 550 - 700 rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL413603A PL229497B1 (en) | 2015-08-20 | 2015-08-20 | Method for producing three-dimensional polylactide scaffolds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL413603A PL229497B1 (en) | 2015-08-20 | 2015-08-20 | Method for producing three-dimensional polylactide scaffolds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL413603A1 true PL413603A1 (en) | 2017-02-27 |
| PL229497B1 PL229497B1 (en) | 2018-07-31 |
Family
ID=58091994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL413603A PL229497B1 (en) | 2015-08-20 | 2015-08-20 | Method for producing three-dimensional polylactide scaffolds |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL229497B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL424205A1 (en) * | 2018-01-05 | 2019-07-15 | Politechnika Warszawska | Method for producing two-function polylactide scaffolds intended for cell cultures |
-
2015
- 2015-08-20 PL PL413603A patent/PL229497B1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL424205A1 (en) * | 2018-01-05 | 2019-07-15 | Politechnika Warszawska | Method for producing two-function polylactide scaffolds intended for cell cultures |
Also Published As
| Publication number | Publication date |
|---|---|
| PL229497B1 (en) | 2018-07-31 |
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