PL411432A1 - Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application - Google Patents

Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application

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Publication number
PL411432A1
PL411432A1 PL411432A PL41143215A PL411432A1 PL 411432 A1 PL411432 A1 PL 411432A1 PL 411432 A PL411432 A PL 411432A PL 41143215 A PL41143215 A PL 41143215A PL 411432 A1 PL411432 A1 PL 411432A1
Authority
PL
Poland
Prior art keywords
iii
soluble
water
gold
intelligent
Prior art date
Application number
PL411432A
Other languages
Polish (pl)
Other versions
PL235135B1 (en
Inventor
Stanisław Szczepaniak
Remigiusz Szczepaniak
Elwira Szczepaniak
Dominika Szczepaniak
Monika Szczepaniak
Original Assignee
Stanisław Szczepaniak
Elwira Szczepaniak
Dominika Szczepaniak
Remigiusz Szczepaniak
Monika Szczepaniak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanisław Szczepaniak, Elwira Szczepaniak, Dominika Szczepaniak, Remigiusz Szczepaniak, Monika Szczepaniak filed Critical Stanisław Szczepaniak
Priority to PL411432A priority Critical patent/PL235135B1/en
Publication of PL411432A1 publication Critical patent/PL411432A1/en
Publication of PL235135B1 publication Critical patent/PL235135B1/en

Links

Abstract

Ujawniono wodorozpuszczalne, inteligentne kompleksy złota (III) o ogólnym wzorze 1: [AU(CN)m]n(m-p)n • (ClO2)rn, gdzie m ma wartość od 3 do 6, n ma wartość od 1 do 10, p ma wartość od 1 do 3, a r ma wartość od 0,1 do 2. Przedmiotem rozwiązania jest również sposób otrzymywania wodorozpuszczalnych, inteligentnych kompleksów złota (III), który polega na tym, że klastry złota wielokrotnie roztwarza się chemicznie, w kwasie solnym (HCl) w obecności przynajmniej 10 molowego nadmiaru chlorków jedno wartościowych metali alkalicznych i każdorazowo odparowuje do sucha, aż do uzyskania wielkości klastrów poniżej 1 nanometra, korzystnie mono-dijonów złota (III), a następnie w roztworze wodnym lub wodno-alkoholowym reaguje z cyjankiem jednowartościowego metalu alkalicznego w stosunku molowym od 1:3 do 1:6 w obecności łagodnego utleniacza, którym jest ditlenek chloru (IV) lub jego prekursor chloran (III) sodu, użyty w stosunku molowym 0,1 do 2 w stosunku do złota (III). Rozwiązanie dotyczy także zastosowania wodorozpuszczalnych, inteligentnych kompleksów złota (III) o wzorze 1, jako pojedynczego leku lub jako składnika środka farmaceutycznego złożonej kompozycji farmaceutycznej w uzasadnionej ilości i dowolnym sposobie podawania w chorobach nowotworowych.Water-soluble intelligent gold (III) complexes with general formula 1 are disclosed: [AU (CN) m] n (mp) n • (ClO2) rn, where m is from 3 to 6, n is from 1 to 10, p has a value from 1 to 3, and a value from 0.1 to 2. The subject of the solution is also the method of obtaining water-soluble, intelligent gold (III) complexes, which consists in the fact that gold clusters are repeatedly chemically dissolved in hydrochloric acid (HCl) ) in the presence of at least 10 molar excess of chlorides of monovalent alkali metals and each time evaporates to dryness until the cluster size is less than 1 nanometer, preferably gold (III) mononionion, and then reacts with a monovalent metal cyanide in aqueous or aqueous-alcoholic solution alkaline in a molar ratio of 1: 3 to 1: 6 in the presence of a mild oxidant, which is chlorine dioxide (IV) or its precursor sodium chlorate (III), used in a molar ratio of 0.1 to 2 relative to evil ta (III). The solution also relates to the use of water-soluble, intelligent gold (III) complexes of formula 1 as a single drug or as a pharmaceutical ingredient in a complex pharmaceutical composition in a reasonable amount and in any method of administration in cancer.

PL411432A 2015-03-01 2015-03-01 Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application PL235135B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL411432A PL235135B1 (en) 2015-03-01 2015-03-01 Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL411432A PL235135B1 (en) 2015-03-01 2015-03-01 Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application

Publications (2)

Publication Number Publication Date
PL411432A1 true PL411432A1 (en) 2016-09-12
PL235135B1 PL235135B1 (en) 2020-06-01

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PL411432A PL235135B1 (en) 2015-03-01 2015-03-01 Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application

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PL (1) PL235135B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019008013A1 (en) 2017-07-04 2019-01-10 Szczepaniak Stanislaw Water-soluble gold (iii) complexes, methods of producing water-soluble gold (iii) complexes and their use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019008013A1 (en) 2017-07-04 2019-01-10 Szczepaniak Stanislaw Water-soluble gold (iii) complexes, methods of producing water-soluble gold (iii) complexes and their use
PL422125A1 (en) * 2017-07-04 2019-01-14 Stanisław Szczepaniak Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application
US11548792B2 (en) 2017-07-04 2023-01-10 Stanislaw SZCZEPANIAK Water-soluble gold (III) complexes, methods of producing water-soluble gold (III) complexes and their use

Also Published As

Publication number Publication date
PL235135B1 (en) 2020-06-01

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