PL410361A1 - 4-amino-N-(1,3-thiazol-2-yl)-benzenesulfonamide-2-aminopyridine crystal and method for producing it - Google Patents

4-amino-N-(1,3-thiazol-2-yl)-benzenesulfonamide-2-aminopyridine crystal and method for producing it

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Publication number
PL410361A1
PL410361A1 PL410361A PL41036114A PL410361A1 PL 410361 A1 PL410361 A1 PL 410361A1 PL 410361 A PL410361 A PL 410361A PL 41036114 A PL41036114 A PL 41036114A PL 410361 A1 PL410361 A1 PL 410361A1
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PL
Poland
Prior art keywords
benzenesulfonamide
aminopyridine
thiazol
amino
crystal
Prior art date
Application number
PL410361A
Other languages
Polish (pl)
Other versions
PL228263B1 (en
Inventor
Veneta Videnova-Adrabińska
Dorota Pogoda
Przemysław Przeworski
Original Assignee
Politechnika Wrocławska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Politechnika Wrocławska filed Critical Politechnika Wrocławska
Priority to PL410361A priority Critical patent/PL228263B1/en
Publication of PL410361A1 publication Critical patent/PL410361A1/en
Publication of PL228263B1 publication Critical patent/PL228263B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Wynalazek dotyczy kokryształu 4-amino-N-(1,3-tiazol-2-ylo)-benzenosulfonamid-2-aminopirydyna o wzorze 1, który znajduje zastosowanie w przemyśle farmaceutycznym. Ujawniono również sposób wytwarzania kokryształu 4-amino-N-(1,3-tiazol-2-ylo)-benzenosulfonamid-2-aminopirydyny o wzorze 1, charakteryzujący się tym, że 0,1 mmol 4-amino-N-(1,3-tiazol-2-ylo)-benzenosulfonamidu i 0,1 mmol 2-aminopirydyny uciera się z acetonem przez 10 do 20 minut. Następnie rozpuszcza się w 2 - 5 ml acetonu oraz 3 - 8 ml metanolu, całość miesza się z szybkością 100 -3 00 rpm przez 10 do 20 minut w temperaturze 40 - 60°C, po czym klarowny roztwór pozostawia się w celu powolnego odparowania rozpuszczalnika w warunkach temperatury pokojowej, w wyniku czego po 3 do 6 dniach uzyskuje się jasnobrązowe kryształy.The invention relates to a 4-amino-N- (1,3-thiazol-2-yl) -benzenesulfonamide-2-aminopyridine co-crystal of formula 1 which is used in the pharmaceutical industry. Also disclosed is a method for producing a 4-amino-N- (1,3-thiazol-2-yl) -benzenesulfonamide-2-aminopyridine co-crystal of formula 1, characterized in that 0.1 mmol of 4-amino-N- (1, 3-thiazol-2-yl) -benzenesulfonamide and 0.1 mmol of 2-aminopyridine are triturated with acetone for 10 to 20 minutes. Then it is dissolved in 2 - 5 ml of acetone and 3 - 8 ml of methanol, the whole is stirred at 100-300 rpm for 10 to 20 minutes at 40 - 60 ° C, after which the clear solution is allowed to slowly evaporate the solvent at room temperature, resulting in light brown crystals after 3 to 6 days.

PL410361A 2014-12-04 2014-12-04 4-amino-N-(1,3-thiazol-2-yl)-benzenesulfonamide-2-aminopyridine crystal and method for producing it PL228263B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL410361A PL228263B1 (en) 2014-12-04 2014-12-04 4-amino-N-(1,3-thiazol-2-yl)-benzenesulfonamide-2-aminopyridine crystal and method for producing it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL410361A PL228263B1 (en) 2014-12-04 2014-12-04 4-amino-N-(1,3-thiazol-2-yl)-benzenesulfonamide-2-aminopyridine crystal and method for producing it

Publications (2)

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PL410361A1 true PL410361A1 (en) 2015-07-20
PL228263B1 PL228263B1 (en) 2018-03-30

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Family Applications (1)

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PL410361A PL228263B1 (en) 2014-12-04 2014-12-04 4-amino-N-(1,3-thiazol-2-yl)-benzenesulfonamide-2-aminopyridine crystal and method for producing it

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PL (1) PL228263B1 (en)

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Publication number Publication date
PL228263B1 (en) 2018-03-30

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