PL407770A1 - Biodegradable, polymer system for the local releasing of medicine to be used in the treatment of parodontium diseases and method for producing it - Google Patents
Biodegradable, polymer system for the local releasing of medicine to be used in the treatment of parodontium diseases and method for producing itInfo
- Publication number
- PL407770A1 PL407770A1 PL407770A PL40777014A PL407770A1 PL 407770 A1 PL407770 A1 PL 407770A1 PL 407770 A PL407770 A PL 407770A PL 40777014 A PL40777014 A PL 40777014A PL 407770 A1 PL407770 A1 PL 407770A1
- Authority
- PL
- Poland
- Prior art keywords
- weight
- composite
- biodegradable
- content
- producing
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 229920000642 polymer Polymers 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 210000004261 periodontium Anatomy 0.000 title 1
- 239000002131 composite material Substances 0.000 abstract 4
- 125000001931 aliphatic group Chemical group 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 208000003433 Gingival Pocket Diseases 0.000 abstract 2
- 239000004098 Tetracycline Substances 0.000 abstract 2
- 229920001577 copolymer Chemical compound 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000004417 polycarbonate Substances 0.000 abstract 2
- 229920000515 polycarbonate Polymers 0.000 abstract 2
- 235000019364 tetracycline Nutrition 0.000 abstract 2
- 150000003522 tetracyclines Chemical class 0.000 abstract 2
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 abstract 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 abstract 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 abstract 1
- 210000003484 anatomy Anatomy 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- -1 caproyl Chemical group 0.000 abstract 1
- 229960003260 chlorhexidine Drugs 0.000 abstract 1
- 229960003722 doxycycline Drugs 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000009434 installation Methods 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 229960000282 metronidazole Drugs 0.000 abstract 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 229960003500 triclosan Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Dental Preparations (AREA)
Abstract
Biodegradowalny, polimerowy system miejscowego uwalniania leku do zastosowania w leczeniu chorób przyzębia, stanowiący wysokoelastyczne, wytrzymałe mechanicznie kompozytowe matryce w postaci typoszeregu, pierścieni i/lub owalnych kształtek, których wymiary są związane z budową anatomiczną i wielkością zębów ludzkich charakteryzuje się tym, że stanowi kompozyt zbudowany z matrycy polimerowej; tworzącej biodegradowalne i biokompatybilne alifatyczne poliestrowęglany i alifatyczne poliwęglany lub/i ich mieszaninę, korzystnie poli(e-kaprolakton -CO- węglan trimetylenu) o zawartości kaproilu od 30 do 85% molowych lub/i alifatyczne poliwęglany, korzystnie poli(węglan trimetylenu - CO- węglan neopentylu) o zawartości komonomeru trimetylowęglanu od 50 do 90% molowych, korzystnie otrzymywane w syntezie prowadzonej metodą eliminującą obecność toksycznych metali w finalnym produkcie, przy czym wypełniaczem zdyspergowanym lub/i rozpuszczonym w matrycy jest antybiotyk rozpuszczalny w wodzie; korzystnie z grupy tetracyklin (tetracyklina, doksycyklina); lub/i antyseptyk, korzystnie chlorheksydyna lub/i metronidazol lub/i triklosan, a zawartość stosowanego leku, wynosi od 5% wagowych do 30% wagowych masy całkowitej kompozytu, korzystnie od 10% wagowych do 20% wagowych, i jest dobierana tak, aby zapewnić jednocześnie odpowiednio wysokie stężenie uwalnianego leku w kieszonce dziąsłowej, pozwalające na wyeliminowanie patogennych bakterii, będących przyczyną schorzenia, a zarazem utrzymując zadawalającą elastyczność i wytrzymałość mechaniczną kompozytu, co pozwala na łatwe, szybkie i trwałe zamocowanie tego systemu. Przedmiotem wynalazku jest także sposób wytwarzania systemu z wymienionych substancji składowych i jego zastosowanie, bez konieczności usuwania systemu z kieszonki dziąsłowej.A biodegradable, polymer system for local drug release for use in the treatment of periodontal diseases, consisting of highly flexible, mechanically durable composite matrices in the form of a series of types, rings and/or oval shapes, the dimensions of which are related to the anatomical structure and size of human teeth, characterized by the fact that it is a composite made of polymer matrix; forming biodegradable and biocompatible aliphatic polyestercarbonates and aliphatic polycarbonates or/or their mixture, preferably poly(e-caprolactone -CO- trimethylene carbonate) with a caproyl content from 30 to 85 mol% and/or aliphatic polycarbonates, preferably poly(trimethylene carbonate -CO- neopentyl carbonate) with a trimethylcarbonate comonomer content of 50 to 90 mol%, preferably obtained in a synthesis carried out by a method that eliminates the presence of toxic metals in the final product, with a water-soluble antibiotic as a filler dispersed and/or dissolved in the matrix; preferably from the group of tetracyclines (tetracycline, doxycycline); and/or antiseptic, preferably chlorhexidine and/or metronidazole and/or triclosan, and the content of the drug used is from 5% by weight to 30% by weight of the total weight of the composite, preferably from 10% by weight to 20% by weight, and is selected so that ensure at the same time a sufficiently high concentration of the drug released in the gingival pocket, allowing the elimination of pathogenic bacteria causing the disease, and at the same time maintaining satisfactory flexibility and mechanical strength of the composite, which allows for easy, quick and permanent installation of this system. The subject of the invention is also a method of producing a system from the listed components and its use, without the need to remove the system from the gingival pocket.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL407770A PL228729B1 (en) | 2014-04-01 | 2014-04-01 | Biodegradable, polymer system for the local releasing of medicine to be used in the treatment of parodontium diseases and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL407770A PL228729B1 (en) | 2014-04-01 | 2014-04-01 | Biodegradable, polymer system for the local releasing of medicine to be used in the treatment of parodontium diseases and method for producing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL407770A1 true PL407770A1 (en) | 2015-10-12 |
| PL228729B1 PL228729B1 (en) | 2018-04-30 |
Family
ID=54266769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL407770A PL228729B1 (en) | 2014-04-01 | 2014-04-01 | Biodegradable, polymer system for the local releasing of medicine to be used in the treatment of parodontium diseases and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL228729B1 (en) |
-
2014
- 2014-04-01 PL PL407770A patent/PL228729B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL228729B1 (en) | 2018-04-30 |
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