PL407399A1 - 2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it
- Google Patents
2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it
Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Medyczny Im. Piastów Śląskich We WrocławiufiledCriticalUniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu
Priority to PL407399ApriorityCriticalpatent/PL407399A1/en
Publication of PL407399A1publicationCriticalpatent/PL407399A1/en
Przedmiotem wynalazku jest nowa pochodna o nazwie chemicznej 1,1-ditlenek 2-[2-(4-fenylopiperazyn-1-ylo)-2-oksoetylo]-4-hydroksy-3-(4-metylobenzoilo)-2H-1,2-benzotiazyny o aktywności przeciwbólowej i przeciwzapalnej oraz sposób otrzymywania nowej pochodnej przez N-alkilację 1,1-diokso-4-hydroksy-3-(4-metylobenzoilo)-2H-1,2-benzotiazyny za pomocą 1-(2-chloroacetylo)-4-fenylopiperazyny w obecności etanolanu sodowego w środowisku wrzącego, bezwodnego etanolu.The present invention relates to a new derivative with the chemical name 2- [2- (4-phenylpiperazin-1-yl) -2-oxoethyl] -4-hydroxy-3- (4-methylbenzoyl) -2H-1,2 -benzothiazine with analgesic and anti-inflammatory activity and the method of obtaining a new derivative by N-alkylation of 1,1-dioxo-4-hydroxy-3- (4-methylbenzoyl) -2H-1,2-benzothiazine with 1- (2-chloroacetyl) -4-phenylpiperazine in the presence of sodium ethoxide in boiling anhydrous ethanol.
PL407399A2014-03-042014-03-042-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it
PL407399A1
(en)
2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it
2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it
2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it
2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it
2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-4-hydroxy-3-(methylobenzoyl)-2H-1,2-benzothiazine 1,1-dioxide with analgesic and anti-inflammatory activity and method for producing it
3-(4-bromobenzoyl)-4-hydroxy-2-{2-[2-pyrimidyl)piperazin-1-yl]-2-oxoethyl}-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it
3-benzyl)-4-hydroxy-2-{2-[4-methoxyphenyl)piperazin-1-yl]2-oxoethyl}-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it
3-benzyl)-4-hydroxy-2-{3-[4-(2-pyridyl)piperazin-1-yl]2-propyl}-2H-1,2-benzothiazine 1,1-dioxide with chemopreventive and antineoplastic chemotherapy supporting activity and method for producing it