PL405937A1 - N-substituted-2-(1-aryloimidazolidin-2-ylideno) hydrazinecarboxamide derivatives, method of obtaining and their applications in medicine - Google Patents

N-substituted-2-(1-aryloimidazolidin-2-ylideno) hydrazinecarboxamide derivatives, method of obtaining and their applications in medicine

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Publication number
PL405937A1
PL405937A1 PL40593713A PL40593713A PL405937A1 PL 405937 A1 PL405937 A1 PL 405937A1 PL 40593713 A PL40593713 A PL 40593713A PL 40593713 A PL40593713 A PL 40593713A PL 405937 A1 PL405937 A1 PL 405937A1
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PL
Poland
Prior art keywords
derivatives
general formula
ylideno
aryloimidazolidin
medicine
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PL40593713A
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Polish (pl)
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PL230780B1 (en
Inventor
Monika Aletańska-Kozak
Dariusz Matosiuk
Urszula Kosikowska
Anna Malm
Original Assignee
Uniwersytet Medyczny W Lublinie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Uniwersytet Medyczny W Lublinie filed Critical Uniwersytet Medyczny W Lublinie
Priority to PL405937A priority Critical patent/PL230780B1/en
Publication of PL405937A1 publication Critical patent/PL405937A1/en
Publication of PL230780B1 publication Critical patent/PL230780B1/en

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Abstract

Przedmiotem wynalazku są pochodne o wzorze ogólnym 1, gdzie R1 oznacza atom wodoru, grupę metylową w pozycji 2 i 3, grupę metoksylowi w pozycji 4 oraz atom chloru w pozycji 4, a R2 oznacza 3-chlorofenyl, 4-chlorofenyl, 3,4-dichlorofenyl, benzyl, 2-chlorobenzyl, 4-chlorobenzyl wykazujące aktywność przeciwdrobnoustrojową oraz ich zastosowanie. Związki według wynalazku otrzymuje się w wyniku reakcji odpowiedniego izocyjanianu o wzorze ogólnym 3, z odpowiednio podstawionymi wolnymi pochodnymi 2-hydrazynylideno-1-aryloimidazolidyny o wzorze ogólnym 2, otrzymanymi z odpowiednio podstawionych jodowodorków w obecności rozpuszczalnika aprotonowego polarnego, stosując proporcje molowe 1:1. Rozpuszczalnik usuwa się przez destylację z łaźni wodnej. Wydzielony osad oczyszcza się przez krystalizację z rozpuszczalnika polarnego.The invention relates to derivatives of general formula 1, where R1 is a hydrogen atom, a methyl group in the 2 and 3 position, a methoxy group in the 4 position and a chlorine atom in the 4 position, and R2 is 3-chlorophenyl, 4-chlorophenyl, 3,4- dichlorophenyl, benzyl, 2-chlorobenzyl, 4-chlorobenzyl with antimicrobial activity and their use. The compounds of the present invention are obtained by reacting the corresponding isocyanate of general formula 3 with suitably substituted free 2-hydrazinylidene-1-arylimidazolidine derivatives of general formula 2, obtained from suitably substituted hydroiodide in the presence of a polar aprotic solvent, using a 1: 1 molar ratio. The solvent is removed by distillation from a water bath. The precipitate formed is purified by crystallization from a polar solvent.

PL405937A 2013-11-06 2013-11-06 N-substituted-2-(1-aryloimidazolidin-2-ylideno) hydrazinecarboxamide derivatives, method of obtaining and their applications in medicine PL230780B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL405937A PL230780B1 (en) 2013-11-06 2013-11-06 N-substituted-2-(1-aryloimidazolidin-2-ylideno) hydrazinecarboxamide derivatives, method of obtaining and their applications in medicine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL405937A PL230780B1 (en) 2013-11-06 2013-11-06 N-substituted-2-(1-aryloimidazolidin-2-ylideno) hydrazinecarboxamide derivatives, method of obtaining and their applications in medicine

Publications (2)

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PL405937A1 true PL405937A1 (en) 2015-05-11
PL230780B1 PL230780B1 (en) 2018-12-31

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PL405937A PL230780B1 (en) 2013-11-06 2013-11-06 N-substituted-2-(1-aryloimidazolidin-2-ylideno) hydrazinecarboxamide derivatives, method of obtaining and their applications in medicine

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PL230780B1 (en) 2018-12-31

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