PL402028A1 - Method for preparing polymorph B form of Prasugrel hydrochloride in pharmaceutical grade - Google Patents
Method for preparing polymorph B form of Prasugrel hydrochloride in pharmaceutical gradeInfo
- Publication number
- PL402028A1 PL402028A1 PL402028A PL40202812A PL402028A1 PL 402028 A1 PL402028 A1 PL 402028A1 PL 402028 A PL402028 A PL 402028A PL 40202812 A PL40202812 A PL 40202812A PL 402028 A1 PL402028 A1 PL 402028A1
- Authority
- PL
- Poland
- Prior art keywords
- prasugrel
- aliphatic
- prasugrel hydrochloride
- pharmaceutical grade
- volume
- Prior art date
Links
- JALHGCPDPSNJNY-UHFFFAOYSA-N [5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-6,7-dihydro-4h-thieno[3,2-c]pyridin-2-yl] acetate;hydron;chloride Chemical compound Cl.C1CC=2SC(OC(=O)C)=CC=2CN1C(C=1C(=CC=CC=1)F)C(=O)C1CC1 JALHGCPDPSNJNY-UHFFFAOYSA-N 0.000 title abstract 3
- 229960004947 prasugrel hydrochloride Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 125000001931 aliphatic group Chemical group 0.000 abstract 3
- 239000005465 B01AC22 - Prasugrel Substances 0.000 abstract 2
- 150000004292 cyclic ethers Chemical class 0.000 abstract 2
- 229960004197 prasugrel Drugs 0.000 abstract 2
- DTGLZDAWLRGWQN-UHFFFAOYSA-N prasugrel Chemical compound C1CC=2SC(OC(=O)C)=CC=2CN1C(C=1C(=CC=CC=1)F)C(=O)C1CC1 DTGLZDAWLRGWQN-UHFFFAOYSA-N 0.000 abstract 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 238000007259 addition reaction Methods 0.000 abstract 1
- 239000012296 anti-solvent Substances 0.000 abstract 1
- 230000006502 antiplatelets effects Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sposób wytwarzania postaci krystalicznej B chlorowodorku prasugrelu o czystości farmaceutycznej polega na tym, że reakcję addycji zasady prasugrelu z chlorowodorem prowadzi się w rozpuszczalniku organicznym wybranym z grupy ketonów, estrów alifatycznych lub eterów alifatycznych bądź cyklicznych, z dodatkiem alkoholu metylowego w ilości 0,1-10% objętościowo w stosunku do objętości użytego wyjściowego rozpuszczalnika i zarodków krystalicznych postaci polimorficznej B chlorowodorku prasugrelu, oraz ewentualnie przeciwrozpuszczalnika wybranego z grupy eterów alifatycznych bądź cyklicznych. Prasugrel, ester 5-[2-cyklopropylo-1-(2-fluorofenylo)-2-oksetylo]-4,5,6,7,- tetrahydrotieno[3,2-c]pirydyn-2-ylowego kwasu octowego, jest związek o działaniu przeciwplytkowym.The method of producing crystalline form B of prasugrel hydrochloride in pharmaceutical purity is that the addition reaction of Prasugrel base with hydrogen chloride is carried out in an organic solvent selected from the group of ketones, aliphatic esters or aliphatic or cyclic ethers, with the addition of 0.1-10 methyl alcohol % by volume in relation to the volume of the starting solvent and crystalline nuclei used, form Prasugrel hydrochloride polymorph B, and optionally an anti-solvent selected from the group of aliphatic or cyclic ethers. Prasugrel, 5- [2-cyclopropyl-1- (2-fluorophenyl) -2-oxetyl] -4,5,6,7, - tetrahydrothieno [3,2-c] pyridin-2-yl acetic acid, is a compound antiplatelet effect.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL402028A PL402028A1 (en) | 2012-12-12 | 2012-12-12 | Method for preparing polymorph B form of Prasugrel hydrochloride in pharmaceutical grade |
| PCT/PL2013/000164 WO2014092589A1 (en) | 2012-12-12 | 2013-12-12 | Process for preparation of prasugrel hydrochloride polymorphic form b of pharmaceutical purity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL402028A PL402028A1 (en) | 2012-12-12 | 2012-12-12 | Method for preparing polymorph B form of Prasugrel hydrochloride in pharmaceutical grade |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL402028A1 true PL402028A1 (en) | 2014-06-23 |
Family
ID=49958649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL402028A PL402028A1 (en) | 2012-12-12 | 2012-12-12 | Method for preparing polymorph B form of Prasugrel hydrochloride in pharmaceutical grade |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL402028A1 (en) |
| WO (1) | WO2014092589A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105669696B (en) * | 2014-11-21 | 2019-03-26 | 四川海思科制药有限公司 | A kind of prasugrel hydrochloride compound |
| CN112898359A (en) * | 2019-12-03 | 2021-06-04 | 晨光生物科技集团股份有限公司 | Preparation method of low-solubility residual crystal |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130118395A (en) | 2000-07-06 | 2013-10-29 | 다이이찌 산쿄 가부시키가이샤 | Hydropyridine derivative acid addition salts |
| TWI392681B (en) | 2006-04-06 | 2013-04-11 | Daiichi Sankyo Co Ltd | Prasugrel with high purity and a method for preparing its acid addition salt |
| SI2032521T1 (en) | 2006-06-27 | 2010-02-26 | Sandoz Ag | New method for salt preparation |
| US20100261908A1 (en) | 2007-11-09 | 2010-10-14 | Dr. Reddy's Laboratories Ltd. | Processes for the preparation of prasugrel , and its salts and polymorphs |
| WO2010070677A2 (en) | 2008-12-15 | 2010-06-24 | Glenmark Generics Limited | A process for the preparation of prasugrel and its pharmaceutically acceptable salts thereof |
| CZ2009828A3 (en) | 2009-12-09 | 2011-06-22 | Zentiva, K.S. | Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride (prasugrelu hydrochloride in polymorphous B form |
| EP2528924A1 (en) | 2010-03-23 | 2012-12-05 | Alembic Pharmaceuticals Limited | A process for the preparation of prasugrel hcl salt |
| WO2012018791A2 (en) * | 2010-08-06 | 2012-02-09 | Dr. Reddy's Laboratories Ltd. | Preparation of prasugrel hydrochloride |
-
2012
- 2012-12-12 PL PL402028A patent/PL402028A1/en unknown
-
2013
- 2013-12-12 WO PCT/PL2013/000164 patent/WO2014092589A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014092589A1 (en) | 2014-06-19 |
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