PL400213A1 - Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors - Google Patents

Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors

Info

Publication number
PL400213A1
PL400213A1 PL400213A PL40021312A PL400213A1 PL 400213 A1 PL400213 A1 PL 400213A1 PL 400213 A PL400213 A PL 400213A PL 40021312 A PL40021312 A PL 40021312A PL 400213 A1 PL400213 A1 PL 400213A1
Authority
PL
Poland
Prior art keywords
group
jak
alkyl groups
imidazo
pyridazine
Prior art date
Application number
PL400213A
Other languages
Polish (pl)
Inventor
Karolina Dzwonek
Michał Mroczkiewicz
Filip Stefaniak
Maciej Wieczorek
Krzysztof Dubiel
Monika Lamparska-Przybysz
Original Assignee
Celon Pharma Spólka Z Ograniczona Odpowiedzialnoscia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celon Pharma Spólka Z Ograniczona Odpowiedzialnoscia filed Critical Celon Pharma Spólka Z Ograniczona Odpowiedzialnoscia
Priority to PL400213A priority Critical patent/PL400213A1/en
Priority to PCT/IB2013/056241 priority patent/WO2014020531A1/en
Publication of PL400213A1 publication Critical patent/PL400213A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgloszenia sa zwiazki przedstawione wzorem ogólnym (I), w którym R1 oznacza H lub C1-C4 alkil, R2 oznacza fenyl podstawiony jednym lub dwoma podstawnikami, wybranymi z grupy skladajacej sie z atomów chlorowca i grup -OC1-C4 alkilowych, R3 oznacza fenyl lub 5-10-czlonowy monocykliczny lub bicykliczny heteroaryl zawierajacy w pierscieniu od 1 do 4 heteroatomów wybranych z grupy skladajacej sie z N, S, i O, który moze byc ewentualnie podstawiony podstawnikiem wybranym z atomów chlorowców, grup C1-C4-alkilowych, i grup -C(O)O-C1-C4-alkil; i X oznacza grupe -CH2- lub grupe karbonylowa -C(O)-; oraz ich sole addycyjne z kwasami. Zwiazki sa inhibitorami kinazy JAK-2 i moga znalezc zastosowanie jako leki w chorobach mieloproliferacyjnych i nowotworowych.The subject of the application are compounds represented by the general formula (I), in which R1 is H or C1-C4 alkyl, R2 is phenyl substituted with one or two substituents selected from the group consisting of halogen atoms and -OC1-C4 alkyl groups, R3 is phenyl or a 5-10 membered monocyclic or bicyclic heteroaryl having 1 to 4 ring heteroatoms selected from the group consisting of N, S, and O, which may be optionally substituted with a substituent selected from halogen, C1-C4-alkyl groups, and -C (O) O-C1-C4-alkyl groups; and X is a -CH2- group or a carbonyl group -C (O) -; and their acid addition salts. The compounds are inhibitors of JAK-2 kinase and may find application as drugs in myeloproliferative diseases and neoplastic diseases.

PL400213A 2012-08-01 2012-08-01 Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors PL400213A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL400213A PL400213A1 (en) 2012-08-01 2012-08-01 Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors
PCT/IB2013/056241 WO2014020531A1 (en) 2012-08-01 2013-07-30 Imidazo[1,2-b]pyridazin-6-amine derivatives as kinase jak-2 inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL400213A PL400213A1 (en) 2012-08-01 2012-08-01 Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors

Publications (1)

Publication Number Publication Date
PL400213A1 true PL400213A1 (en) 2014-02-03

Family

ID=49301568

Family Applications (1)

Application Number Title Priority Date Filing Date
PL400213A PL400213A1 (en) 2012-08-01 2012-08-01 Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors

Country Status (2)

Country Link
PL (1) PL400213A1 (en)
WO (1) WO2014020531A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007292924A1 (en) 2006-09-07 2008-03-13 Biogen Idec Ma Inc. IRAK modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder
PA8851101A1 (en) 2008-12-16 2010-07-27 Lilly Co Eli AMINO PIRAZOL COMPOUND

Also Published As

Publication number Publication date
WO2014020531A1 (en) 2014-02-06

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