PL394824A1 - Nanoemulsion of oil in water type, method for the preparation and use thereof - Google Patents

Nanoemulsion of oil in water type, method for the preparation and use thereof

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Publication number
PL394824A1
PL394824A1 PL394824A PL39482411A PL394824A1 PL 394824 A1 PL394824 A1 PL 394824A1 PL 394824 A PL394824 A PL 394824A PL 39482411 A PL39482411 A PL 39482411A PL 394824 A1 PL394824 A1 PL 394824A1
Authority
PL
Poland
Prior art keywords
oil
nanoemulsion
weight
ranging
preparation
Prior art date
Application number
PL394824A
Other languages
Polish (pl)
Other versions
PL226873B1 (en
Inventor
Urszula Bazylinska
Kazimiera A. Wilk
Jadwiga Pietkiewicz
Jolanta Saczko
Original Assignee
Wroclawskie Centrum Badan Eit + Spólka Z Ograniczona Odpowiedzialnoscia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Wroclawskie Centrum Badan Eit + Spólka Z Ograniczona Odpowiedzialnoscia filed Critical Wroclawskie Centrum Badan Eit + Spólka Z Ograniczona Odpowiedzialnoscia
Priority to PL394824A priority Critical patent/PL226873B1/en
Publication of PL394824A1 publication Critical patent/PL394824A1/en
Publication of PL226873B1 publication Critical patent/PL226873B1/en

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  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)

Abstract

Przedmiotem wynalazku jest nanoemulsja i sposób wytwarzania nanoemulsji typu olej w wodzie, przeznaczonych do stosowania farmaceutycznego, jako nanonośniki hydrofobowych substancji aktywnych użytecznych w terapiach przeciwnowotworowych. Zgodnie z wynalazkiem, sposób wytwarzania nanoemulsji typu olej w wodzie, na bazie biokompatybilnych olejów, które stabilizowane są niejonowymi surfaktantami wybranymi z grupy polioksyetylatów, polega na tym, że miesza się surfaktant niejonowy w proporcji od 1 do 40% wagowych z fazą olejową, którą stanowią bikompatybilne oleje mirystynian izopropylu i olej sojowy, w zakresie od 0,1 do 20% wag. i z fazą wodną w zakresie od 60 do 99% wag., a następnie trzyskładnikową mieszaninę poddaje się działaniu ultradźwięków i otrzymuje półprzeźroczystą, opalizującą nanoemulsję, której biologiczne bezpieczeństwo zostało przebadane na liniach komórkowych.The subject of the invention is a nanoemulsion and a method for producing oil-in-water nanoemulsions intended for pharmaceutical use as nanocarriers of hydrophobic active substances useful in anticancer therapies. According to the invention, the method of producing oil-in-water nanoemulsions based on biocompatible oils, which are stabilized with non-ionic surfactants selected from the group of polyoxyethylates, consists in mixing the non-ionic surfactant in a proportion from 1 to 40% by weight with the oil phase, which constitutes bicompatible oils isopropyl myristate and soybean oil, ranging from 0.1 to 20% by weight. and with an aqueous phase ranging from 60 to 99% by weight, and then the three-component mixture is exposed to ultrasound to obtain a semi-transparent, opalescent nanoemulsion, the biological safety of which has been tested on cell lines.

PL394824A 2011-05-10 2011-05-10 Nanoemulsion of oil in water type, method for the preparation and use thereof PL226873B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL394824A PL226873B1 (en) 2011-05-10 2011-05-10 Nanoemulsion of oil in water type, method for the preparation and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL394824A PL226873B1 (en) 2011-05-10 2011-05-10 Nanoemulsion of oil in water type, method for the preparation and use thereof

Publications (2)

Publication Number Publication Date
PL394824A1 true PL394824A1 (en) 2012-11-19
PL226873B1 PL226873B1 (en) 2017-09-29

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ID=47263925

Family Applications (1)

Application Number Title Priority Date Filing Date
PL394824A PL226873B1 (en) 2011-05-10 2011-05-10 Nanoemulsion of oil in water type, method for the preparation and use thereof

Country Status (1)

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PL (1) PL226873B1 (en)

Also Published As

Publication number Publication date
PL226873B1 (en) 2017-09-29

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