PL394824A1 - Nanoemulsion of oil in water type, method for the preparation and use thereof - Google Patents
Nanoemulsion of oil in water type, method for the preparation and use thereofInfo
- Publication number
- PL394824A1 PL394824A1 PL394824A PL39482411A PL394824A1 PL 394824 A1 PL394824 A1 PL 394824A1 PL 394824 A PL394824 A PL 394824A PL 39482411 A PL39482411 A PL 39482411A PL 394824 A1 PL394824 A1 PL 394824A1
- Authority
- PL
- Poland
- Prior art keywords
- oil
- nanoemulsion
- weight
- ranging
- preparation
- Prior art date
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- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
Abstract
Przedmiotem wynalazku jest nanoemulsja i sposób wytwarzania nanoemulsji typu olej w wodzie, przeznaczonych do stosowania farmaceutycznego, jako nanonośniki hydrofobowych substancji aktywnych użytecznych w terapiach przeciwnowotworowych. Zgodnie z wynalazkiem, sposób wytwarzania nanoemulsji typu olej w wodzie, na bazie biokompatybilnych olejów, które stabilizowane są niejonowymi surfaktantami wybranymi z grupy polioksyetylatów, polega na tym, że miesza się surfaktant niejonowy w proporcji od 1 do 40% wagowych z fazą olejową, którą stanowią bikompatybilne oleje mirystynian izopropylu i olej sojowy, w zakresie od 0,1 do 20% wag. i z fazą wodną w zakresie od 60 do 99% wag., a następnie trzyskładnikową mieszaninę poddaje się działaniu ultradźwięków i otrzymuje półprzeźroczystą, opalizującą nanoemulsję, której biologiczne bezpieczeństwo zostało przebadane na liniach komórkowych.The subject of the invention is a nanoemulsion and a method for producing oil-in-water nanoemulsions intended for pharmaceutical use as nanocarriers of hydrophobic active substances useful in anticancer therapies. According to the invention, the method of producing oil-in-water nanoemulsions based on biocompatible oils, which are stabilized with non-ionic surfactants selected from the group of polyoxyethylates, consists in mixing the non-ionic surfactant in a proportion from 1 to 40% by weight with the oil phase, which constitutes bicompatible oils isopropyl myristate and soybean oil, ranging from 0.1 to 20% by weight. and with an aqueous phase ranging from 60 to 99% by weight, and then the three-component mixture is exposed to ultrasound to obtain a semi-transparent, opalescent nanoemulsion, the biological safety of which has been tested on cell lines.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL394824A PL226873B1 (en) | 2011-05-10 | 2011-05-10 | Nanoemulsion of oil in water type, method for the preparation and use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL394824A PL226873B1 (en) | 2011-05-10 | 2011-05-10 | Nanoemulsion of oil in water type, method for the preparation and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
PL394824A1 true PL394824A1 (en) | 2012-11-19 |
PL226873B1 PL226873B1 (en) | 2017-09-29 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL394824A PL226873B1 (en) | 2011-05-10 | 2011-05-10 | Nanoemulsion of oil in water type, method for the preparation and use thereof |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL226873B1 (en) |
-
2011
- 2011-05-10 PL PL394824A patent/PL226873B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL226873B1 (en) | 2017-09-29 |
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