PL391681A1 - Process for the preparation of quinolinothiosemicarbasone derivatives and the use thereof - Google Patents
Process for the preparation of quinolinothiosemicarbasone derivatives and the use thereofInfo
- Publication number
- PL391681A1 PL391681A1 PL391681A PL39168110A PL391681A1 PL 391681 A1 PL391681 A1 PL 391681A1 PL 391681 A PL391681 A PL 391681A PL 39168110 A PL39168110 A PL 39168110A PL 391681 A1 PL391681 A1 PL 391681A1
- Authority
- PL
- Poland
- Prior art keywords
- preparation
- derivatives
- quinolinothiosemicarbasone
- atom
- methyl group
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Wynalazek obejmuje nowy sposób otrzymywania pochodnych chinolinotiosemikarbazonu o ogólnym wzorze 1, w którym A oznacza łącznik zawierający zero lub jeden atom węgla; R1 i R2 oznaczają podstawniki identyczne lub różne, takie jak atom wodoru, grupa hydroksylowa lub atom chloru; R3 oznacza atom wodoru lub grupę nitrową; R4 oznacza atom wodoru lub grupę metylową, a R5 oznacza grupę metylową, etylową lub pierścień fenylowy. Ponadto przedmiotem wynalazku jest zastosowanie wskazanych związków do wytwarzania środków farmaceutycznych do hamowania proliferacji komórek rakowych i w konsekwencji do leczenia raka.The invention includes a new method for the preparation of quinoline thiosemicarbazone derivatives of the general formula I, wherein A is a linker containing zero or one carbon atom; R1 and R2 are identical or different substituents, such as a hydrogen atom, a hydroxyl group or a chlorine atom; R3 is hydrogen or nitro; R4 is a hydrogen atom or a methyl group and R5 is a methyl group, an ethyl group or a phenyl ring. Furthermore, the invention relates to the use of said compounds for the production of pharmaceutical agents for inhibiting the proliferation of cancer cells and consequently for treating cancer.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL391681A PL218496B1 (en) | 2010-06-30 | 2010-06-30 | Process for the preparation of quinolinothiosemicarbasone derivatives and the use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL391681A PL218496B1 (en) | 2010-06-30 | 2010-06-30 | Process for the preparation of quinolinothiosemicarbasone derivatives and the use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
PL391681A1 true PL391681A1 (en) | 2012-01-02 |
PL218496B1 PL218496B1 (en) | 2014-12-31 |
Family
ID=45510073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL391681A PL218496B1 (en) | 2010-06-30 | 2010-06-30 | Process for the preparation of quinolinothiosemicarbasone derivatives and the use thereof |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL218496B1 (en) |
-
2010
- 2010-06-30 PL PL391681A patent/PL218496B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL218496B1 (en) | 2014-12-31 |
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PL391681A1 (en) | Process for the preparation of quinolinothiosemicarbasone derivatives and the use thereof |