PL390079A1 - Process for the preparation of vardenafil and its isolation as a salt with citric acid and a crystalline form of this salt - Google Patents

Process for the preparation of vardenafil and its isolation as a salt with citric acid and a crystalline form of this salt

Info

Publication number
PL390079A1
PL390079A1 PL390079A PL39007909A PL390079A1 PL 390079 A1 PL390079 A1 PL 390079A1 PL 390079 A PL390079 A PL 390079A PL 39007909 A PL39007909 A PL 39007909A PL 390079 A1 PL390079 A1 PL 390079A1
Authority
PL
Poland
Prior art keywords
salt
vardenafil
isolation
preparation
citric acid
Prior art date
Application number
PL390079A
Other languages
Polish (pl)
Inventor
Cezariusz Falkowski
Dawid Jan Ignatowicz
Original Assignee
Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna filed Critical Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna
Priority to PL390079A priority Critical patent/PL390079A1/en
Priority to PCT/EP2010/007908 priority patent/WO2011079935A2/en
Publication of PL390079A1 publication Critical patent/PL390079A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL390079A 2009-12-30 2009-12-30 Process for the preparation of vardenafil and its isolation as a salt with citric acid and a crystalline form of this salt PL390079A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL390079A PL390079A1 (en) 2009-12-30 2009-12-30 Process for the preparation of vardenafil and its isolation as a salt with citric acid and a crystalline form of this salt
PCT/EP2010/007908 WO2011079935A2 (en) 2009-12-30 2010-12-23 A process for the preparation and isolation of vardenafil and salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL390079A PL390079A1 (en) 2009-12-30 2009-12-30 Process for the preparation of vardenafil and its isolation as a salt with citric acid and a crystalline form of this salt

Publications (1)

Publication Number Publication Date
PL390079A1 true PL390079A1 (en) 2011-07-04

Family

ID=44246941

Family Applications (1)

Application Number Title Priority Date Filing Date
PL390079A PL390079A1 (en) 2009-12-30 2009-12-30 Process for the preparation of vardenafil and its isolation as a salt with citric acid and a crystalline form of this salt

Country Status (2)

Country Link
PL (1) PL390079A1 (en)
WO (1) WO2011079935A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ303877B6 (en) * 2011-11-24 2013-06-05 Zentiva, K.S. Process for preparing and isolation of acid vardenafil salts
CN104109164B (en) * 2013-04-18 2016-05-25 广州朗圣药业有限公司 A kind of preparation method who is applicable to industrialized high-purity hydrochloric acid Vardenafil trihydrate
EP3082428A4 (en) 2013-12-09 2017-08-02 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL111239B1 (en) 1976-12-29 1980-08-30 Energiagazdalkodasi Intezet Process for purification of lean natural gas and apparatus therefor
ATE213246T1 (en) * 1997-11-12 2002-02-15 2-PHENYL-SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS
GB9823103D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
DE10063108A1 (en) * 2000-12-18 2002-06-20 Bayer Ag Process for the preparation of sulfonamide-substituted imidazotriazinones
DE10232113A1 (en) 2002-07-16 2004-01-29 Bayer Ag Medicinal products containing vardenafil hydrochloride trihydrate
US20050196418A1 (en) * 2004-03-04 2005-09-08 Yu Ruey J. Bioavailability and improved delivery of alkaline pharmaceutical drugs
DE102005009241A1 (en) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Dosage forms with controlled bioavailability
US7977478B2 (en) 2006-03-13 2011-07-12 Dr. Reddy's Laboratories Limited Polymorphic forms of vardenafil

Also Published As

Publication number Publication date
WO2011079935A2 (en) 2011-07-07
WO2011079935A3 (en) 2012-03-15

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