PL338178A1 - Pharmaceutic composition containing sole lysotaphin or in combination with an antibiotic for treating staphylococcal infections - Google Patents
Pharmaceutic composition containing sole lysotaphin or in combination with an antibiotic for treating staphylococcal infectionsInfo
- Publication number
- PL338178A1 PL338178A1 PL98338178A PL33817898A PL338178A1 PL 338178 A1 PL338178 A1 PL 338178A1 PL 98338178 A PL98338178 A PL 98338178A PL 33817898 A PL33817898 A PL 33817898A PL 338178 A1 PL338178 A1 PL 338178A1
- Authority
- PL
- Poland
- Prior art keywords
- lysotaphin
- antibiotic
- combination
- composition containing
- staphylococcal infections
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24075—Lysostaphin (3.4.24.75)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Lysostaphin is demonstrated to be a powerful anti-staphylococcal agent suitable for parenteral administration to mammals including humans. Low dosages, on the order of 0.5 - 45 mg/kg/day are sufficient to eradicate most staphylococcal infections. Lysostaphin is also effective against bacteria of this type which have developed resistance to conventional antibiotics such as penicillins and vancomycin. Lysostaphin analogues, such as variants and related enzymes, show similar activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5347097P | 1997-07-23 | 1997-07-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL338178A1 true PL338178A1 (en) | 2000-10-09 |
Family
ID=21984478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL98338178A PL338178A1 (en) | 1997-07-23 | 1998-07-21 | Pharmaceutic composition containing sole lysotaphin or in combination with an antibiotic for treating staphylococcal infections |
Country Status (20)
Country | Link |
---|---|
US (1) | US20020006406A1 (en) |
EP (1) | EP1001804B1 (en) |
JP (1) | JP2001510805A (en) |
KR (1) | KR20010022237A (en) |
CN (1) | CN1269727A (en) |
AT (1) | ATE316794T1 (en) |
AU (1) | AU754806B2 (en) |
BR (1) | BR9811535A (en) |
CA (1) | CA2297083C (en) |
DE (1) | DE69833377T2 (en) |
HU (1) | HUP0002662A3 (en) |
IL (1) | IL134056A0 (en) |
NO (1) | NO320884B1 (en) |
NZ (1) | NZ502359A (en) |
PL (1) | PL338178A1 (en) |
RU (1) | RU2234940C2 (en) |
SK (1) | SK732000A3 (en) |
TW (1) | TWI235656B (en) |
WO (1) | WO1999004809A1 (en) |
ZA (1) | ZA986593B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6423299B1 (en) | 1997-10-31 | 2002-07-23 | Vincent Fischetti | Composition for treatment of a bacterial infection of an upper respiratory tract |
US6428784B1 (en) | 1997-10-31 | 2002-08-06 | New Horizons Diagnostics Corp | Vaginal suppository for treating group B Streptococcus infection |
US7232576B2 (en) | 1997-10-31 | 2007-06-19 | New Horizons Diagnostics Corp | Throat lozenge for the treatment of Streptococcus Group A |
US6277399B1 (en) | 1997-10-31 | 2001-08-21 | New Horizon Diagnostics Corporation | Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections |
US6056954A (en) * | 1997-10-31 | 2000-05-02 | New Horizons Diagnostics Corp | Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses |
US6399097B1 (en) | 1997-10-31 | 2002-06-04 | New Horizons Diagnostics Corporation | Composition for treatment of a bacterial infection of the digestive tract |
US6432444B1 (en) | 1997-10-31 | 2002-08-13 | New Horizons Diagnostics Corp | Use of bacterial phage associated lysing enzymes for treating dermatological infections |
US6399098B1 (en) | 1997-10-31 | 2002-06-04 | New Horizons Diagnostics Corp | Composition for treating dental caries caused by streptococcus mutans |
US6406692B1 (en) | 1997-10-31 | 2002-06-18 | New Horizons Diagnostics Corp | Composition for treatment of an ocular bacterial infection |
US6569830B1 (en) | 1999-03-05 | 2003-05-27 | Ambi, Inc. | Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains |
US20020127215A1 (en) * | 1999-09-14 | 2002-09-12 | Lawrence Loomis | Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections |
AU2001259205A1 (en) * | 2000-04-28 | 2001-11-12 | New Horizons Diagnostic Corporation | The use of bacterial phage associated lysing enzymes for treating various illnesses |
US6395504B1 (en) | 2000-09-01 | 2002-05-28 | New Horizons Diagnostics Corp. | Use of phage associated lytic enzymes for the rapid detection of bacterial contaminants |
US7572439B2 (en) * | 2002-03-26 | 2009-08-11 | Biosynexus Incorporated | Enzyme disruption of bacterial biofilms |
EP1567868A4 (en) * | 2002-12-02 | 2008-02-06 | Biosynexus Inc | Wall teichoic acid as a target for anti-staphylococcal therapies and vaccines |
CN1744905A (en) * | 2002-12-10 | 2006-03-08 | 百敖新纳斯有限公司 | Topical anti-infective formulations |
US20100221237A1 (en) * | 2003-03-26 | 2010-09-02 | Biosynexus Incorporated | Enzyme disruption of bacterial biofilms |
WO2006076058A1 (en) * | 2005-01-10 | 2006-07-20 | Nabi Biopharmaceuticals | Method of treating staphylococcus aureus infection |
EP1885403B1 (en) | 2005-04-12 | 2013-05-08 | Nektar Therapeutics | Poly(ethyleneglycol) conjugates of Lysostaphin |
US7943128B2 (en) | 2006-03-31 | 2011-05-17 | The University Court Of The University Of St Andrews | Anti-microbial compositions comprising a cationic peptide and a glycylglycine endopeptidase |
CN101437532B (en) | 2006-05-05 | 2013-08-21 | 冈戈根股份有限公司 | Phage derived antimicrobial activities |
WO2009114520A2 (en) * | 2008-03-10 | 2009-09-17 | Pharmain Corporation | Compositions for treatment with metallopeptidases, methods of making and using the same |
WO2009150171A1 (en) * | 2008-06-10 | 2009-12-17 | Profos Ag | Method of treatment of inflammatory diseases |
US11155801B2 (en) | 2013-08-06 | 2021-10-26 | Trustees Of Dartmouth College | Unglycosylated lysostaphin variant protein |
RU2572341C2 (en) * | 2013-09-20 | 2016-01-10 | Федеральное государственное бюджетное учреждение Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе Российской академии медицинских наук (ФГБУ "НИИНА" РАМН) | ANTIBIOTIC INA 5812, STRAIN-PRODUCER Streptomyces roseoflavus INA-As-5812 AND METHOD FOR ANTIBIOTIC OBTAINING |
EP3485899A4 (en) * | 2017-09-25 | 2020-05-20 | Georgy Georgievich Chumburidze | Thermostable composition with antiviral and antibacterial activity and use thereof |
US11565024B2 (en) | 2017-11-16 | 2023-01-31 | Georgia Tech Research Corporation | Lysostaphin containing synthetic hydrogel carriers for bone repair |
CN110917339B (en) * | 2019-12-27 | 2023-07-07 | 遵义医学院附属医院 | Lysostaphin gel and application thereof in MRSA (tissue-specific respiratory tract infection) wound surface |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5858962A (en) * | 1987-05-11 | 1999-01-12 | Ambi Inc. | Composition for treating mastitis and other staphylococcal infections |
AU623864B2 (en) * | 1988-08-29 | 1992-05-28 | Applied Microbiology, Inc | Method of treating mastitis and other staphylococcal infections |
-
1998
- 1998-07-21 JP JP2000503861A patent/JP2001510805A/en active Pending
- 1998-07-21 CA CA002297083A patent/CA2297083C/en not_active Expired - Fee Related
- 1998-07-21 EP EP98935954A patent/EP1001804B1/en not_active Expired - Lifetime
- 1998-07-21 US US09/120,030 patent/US20020006406A1/en not_active Abandoned
- 1998-07-21 CN CN98808669A patent/CN1269727A/en active Pending
- 1998-07-21 DE DE69833377T patent/DE69833377T2/en not_active Expired - Lifetime
- 1998-07-21 AT AT98935954T patent/ATE316794T1/en not_active IP Right Cessation
- 1998-07-21 NZ NZ502359A patent/NZ502359A/en unknown
- 1998-07-21 PL PL98338178A patent/PL338178A1/en not_active Application Discontinuation
- 1998-07-21 BR BR9811535-9A patent/BR9811535A/en not_active IP Right Cessation
- 1998-07-21 AU AU85095/98A patent/AU754806B2/en not_active Ceased
- 1998-07-21 HU HU0002662A patent/HUP0002662A3/en unknown
- 1998-07-21 SK SK73-2000A patent/SK732000A3/en unknown
- 1998-07-21 WO PCT/US1998/015257 patent/WO1999004809A1/en not_active Application Discontinuation
- 1998-07-21 IL IL13405698A patent/IL134056A0/en unknown
- 1998-07-21 KR KR1020007000810A patent/KR20010022237A/en not_active Application Discontinuation
- 1998-07-21 RU RU2000104516/15A patent/RU2234940C2/en not_active IP Right Cessation
- 1998-07-23 ZA ZA986593A patent/ZA986593B/en unknown
- 1998-08-29 TW TW087112047A patent/TWI235656B/en not_active IP Right Cessation
-
2000
- 2000-01-21 NO NO20000314A patent/NO320884B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TWI235656B (en) | 2005-07-11 |
CN1269727A (en) | 2000-10-11 |
EP1001804A1 (en) | 2000-05-24 |
HUP0002662A2 (en) | 2000-12-28 |
DE69833377T2 (en) | 2006-11-16 |
NO20000314L (en) | 2000-03-16 |
NZ502359A (en) | 2005-02-25 |
US20020006406A1 (en) | 2002-01-17 |
BR9811535A (en) | 2000-08-29 |
HUP0002662A3 (en) | 2003-08-28 |
KR20010022237A (en) | 2001-03-15 |
ZA986593B (en) | 1999-02-04 |
NO320884B1 (en) | 2006-02-06 |
NO20000314D0 (en) | 2000-01-21 |
WO1999004809A1 (en) | 1999-02-04 |
CA2297083A1 (en) | 1999-02-04 |
JP2001510805A (en) | 2001-08-07 |
HU0002662D0 (en) | 2000-08-28 |
AU754806B2 (en) | 2002-11-28 |
CA2297083C (en) | 2007-10-30 |
RU2234940C2 (en) | 2004-08-27 |
EP1001804B1 (en) | 2006-02-01 |
AU8509598A (en) | 1999-02-16 |
SK732000A3 (en) | 2001-03-12 |
IL134056A0 (en) | 2001-04-30 |
ATE316794T1 (en) | 2006-02-15 |
DE69833377D1 (en) | 2006-04-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |