PL296165A1 - Method of obtaining diastereoselective reducing pinacolic coupling of homochiral -aminoaldehydes - Google Patents

Method of obtaining diastereoselective reducing pinacolic coupling of homochiral -aminoaldehydes

Info

Publication number
PL296165A1
PL296165A1 PL29616592A PL29616592A PL296165A1 PL 296165 A1 PL296165 A1 PL 296165A1 PL 29616592 A PL29616592 A PL 29616592A PL 29616592 A PL29616592 A PL 29616592A PL 296165 A1 PL296165 A1 PL 296165A1
Authority
PL
Poland
Prior art keywords
aminoaldehydes
homochiral
diastereoselective
obtaining
reducing
Prior art date
Application number
PL29616592A
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PL296165A1 publication Critical patent/PL296165A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A process for the preparation of optically pure symmetrical compounds of the formula I <IMAGE> is described, in which R<1>, R<2> and R<3> are explained in the description, with simultaneous control of the four centres of chirality marked by *.
PL29616592A 1991-10-07 1992-10-06 Method of obtaining diastereoselective reducing pinacolic coupling of homochiral -aminoaldehydes PL296165A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4133202 1991-10-07

Publications (1)

Publication Number Publication Date
PL296165A1 true PL296165A1 (en) 1993-05-17

Family

ID=6442200

Family Applications (1)

Application Number Title Priority Date Filing Date
PL29616592A PL296165A1 (en) 1991-10-07 1992-10-06 Method of obtaining diastereoselective reducing pinacolic coupling of homochiral -aminoaldehydes

Country Status (13)

Country Link
US (1) US5463124A (en)
EP (1) EP0541946B1 (en)
JP (1) JP3254263B2 (en)
KR (1) KR930007893A (en)
AT (1) ATE140449T1 (en)
CA (1) CA2079953A1 (en)
CZ (1) CZ304492A3 (en)
DE (1) DE59206778D1 (en)
FI (1) FI924477A (en)
HU (1) HUT63607A (en)
MX (1) MX9205724A (en)
NO (1) NO923879L (en)
PL (1) PL296165A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494403A (en) * 1992-04-14 1996-02-27 Ebara Corporation Full-circumferential flow pump
PT1064298E (en) * 1998-03-19 2009-01-02 Vertex Pharma Inhibitors of caspases
PE20011350A1 (en) * 2000-05-19 2002-01-15 Vertex Pharma PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE)
AU2002357767C1 (en) * 2001-11-26 2009-03-19 Trustees Of Tufts College Peptidomimetic inhibitors of post-proline cleaving enzymes
WO2003068242A1 (en) * 2002-02-11 2003-08-21 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
AU2003265276A1 (en) 2002-07-15 2004-02-02 The Trustees Of Princeton University Iap binding compounds
CN1980658A (en) * 2004-05-27 2007-06-13 沃泰克斯药物股份有限公司 Treatment of diseases using ICE inhibitors
EP3426674A4 (en) 2016-03-09 2019-08-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
CA3038331A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
DE4030350A1 (en) * 1989-09-28 1991-04-11 Hoechst Ag New retro:virus protease-inhibiting oligopeptide derivs. - for treatment of retro-viral infection e.g. AIDS
EP0428849A3 (en) * 1989-09-28 1991-07-31 Hoechst Aktiengesellschaft Retroviral protease inhibitors
HU9203505D0 (en) * 1990-06-01 1993-01-28 Du Pont Merck Pharma 1,4-diamino-2,3-dihydroxi-butane compounds

Also Published As

Publication number Publication date
HUT63607A (en) 1993-09-28
CA2079953A1 (en) 1993-04-08
JPH05239000A (en) 1993-09-17
KR930007893A (en) 1993-05-20
FI924477A0 (en) 1992-10-05
EP0541946A1 (en) 1993-05-19
HU9203163D0 (en) 1992-12-28
ATE140449T1 (en) 1996-08-15
EP0541946B1 (en) 1996-07-17
MX9205724A (en) 1993-04-01
FI924477A (en) 1993-04-08
US5463124A (en) 1995-10-31
NO923879L (en) 1993-04-13
NO923879D0 (en) 1992-10-06
JP3254263B2 (en) 2002-02-04
DE59206778D1 (en) 1996-08-22
CZ304492A3 (en) 1993-05-12

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