PL2772484T3 - Bicyclic heterocyclic compound - Google Patents

Bicyclic heterocyclic compound

Info

Publication number
PL2772484T3
PL2772484T3 PL12840990T PL12840990T PL2772484T3 PL 2772484 T3 PL2772484 T3 PL 2772484T3 PL 12840990 T PL12840990 T PL 12840990T PL 12840990 T PL12840990 T PL 12840990T PL 2772484 T3 PL2772484 T3 PL 2772484T3
Authority
PL
Poland
Prior art keywords
heterocyclic compound
bicyclic heterocyclic
bicyclic
compound
heterocyclic
Prior art date
Application number
PL12840990T
Other languages
Polish (pl)
Inventor
Shimpei Kawakami
Minoru Sakurai
Noriyuki Kawano
Takayuki Suzuki
Nobuyuki Shiraishi
Wataru Hamaguchi
Ryuichi Sekioka
Hiroyuki Moritomo
Ayako Moritomo
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of PL2772484T3 publication Critical patent/PL2772484T3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28Cinnolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/78Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
PL12840990T 2011-10-18 2012-10-17 Bicyclic heterocyclic compound PL2772484T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011228822 2011-10-18
EP12840990.1A EP2772484B1 (en) 2011-10-18 2012-10-17 Bicyclic heterocyclic compound
PCT/JP2012/076771 WO2013058258A1 (en) 2011-10-18 2012-10-17 Bicyclic heterocyclic compound

Publications (1)

Publication Number Publication Date
PL2772484T3 true PL2772484T3 (en) 2017-10-31

Family

ID=48140904

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12840990T PL2772484T3 (en) 2011-10-18 2012-10-17 Bicyclic heterocyclic compound

Country Status (27)

Country Link
US (1) US9266840B2 (en)
EP (1) EP2772484B1 (en)
JP (1) JP6020459B2 (en)
KR (1) KR101987514B1 (en)
CN (1) CN103917524B (en)
AR (1) AR088378A1 (en)
AU (1) AU2012327076B2 (en)
BR (1) BR112014009524A2 (en)
CA (1) CA2851589C (en)
CY (1) CY1119181T1 (en)
DK (1) DK2772484T3 (en)
EA (1) EA024846B1 (en)
ES (1) ES2641258T3 (en)
HR (1) HRP20171125T1 (en)
IL (1) IL232061A (en)
IN (1) IN2014CN02949A (en)
LT (1) LT2772484T (en)
ME (1) ME02733B (en)
MX (1) MX344014B (en)
PL (1) PL2772484T3 (en)
PT (1) PT2772484T (en)
RS (1) RS56288B1 (en)
SI (1) SI2772484T1 (en)
TW (1) TWI545113B (en)
UA (1) UA112327C2 (en)
WO (1) WO2013058258A1 (en)
ZA (1) ZA201403513B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013166013A1 (en) 2012-04-30 2013-11-07 Anderson Gaweco Ror modulators and their uses
US9045477B2 (en) 2013-03-15 2015-06-02 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
US9776996B2 (en) * 2013-03-15 2017-10-03 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
CN107922386B (en) * 2015-06-22 2021-04-02 大日本住友制药株式会社 1, 4-disubstituted imidazole derivatives
CN108129430A (en) * 2016-11-30 2018-06-08 重庆圣华曦药业股份有限公司 A kind of synthetic method of Li Tasite intermediates
CN115925692A (en) * 2022-11-28 2023-04-07 浙江理工大学 Preparation method of trifluoromethyl substituted enamine compound

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3770726D1 (en) * 1986-08-12 1991-07-18 Roussel Uclaf DECAHYDROCHINOLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND INTERMEDIATE PRODUCTS THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND THEIR PHARMACEUTICAL COMPOSITIONS.
GB8907865D0 (en) * 1989-04-07 1989-05-24 Wyeth John & Brother Ltd Tetrahydroquinoline derivatives
US5194439A (en) * 1990-04-06 1993-03-16 John Wyeth & Brother Limited N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fused cycloalkanes
EP0787721B1 (en) 1995-07-20 1999-04-28 Toray Industries, Inc. 4a-ARYLDECAHYDROISOQUINOLINE COMPOUNDS AND MEDICINAL USES THEREOF
JP2003527395A (en) 2000-03-17 2003-09-16 ノボ ノルディスク アクティーゼルスカブ Fused imidazoles as histamine H3 receptor ligands
CA2479928A1 (en) 2002-03-28 2003-10-09 Neurogen Corporation Substituted biaryl amides as c5a receptor modulators
EP1615698B1 (en) 2003-04-11 2010-09-29 High Point Pharmaceuticals, LLC New amide derivatives and pharmaceutical use thereof
EP1675844A1 (en) * 2003-10-23 2006-07-05 Sterix Limited Phenyl carboxamide and sulfonamide derivatives for use as 11-beta-hydroxysteroid dehydrogenase
US7842810B2 (en) 2005-03-31 2010-11-30 Janssen Pharmaceutica, Nv Bicyclic pyrazole compounds as antibacterial agents
EP1864971A4 (en) * 2005-03-31 2010-02-10 Takeda Pharmaceutical Prophylactic/therapeutic agent for diabetes
WO2007050124A1 (en) 2005-05-19 2007-05-03 Xenon Pharmaceuticals Inc. Fused piperidine derivatives and their uses as therapeutic agents
US8952176B2 (en) 2005-06-07 2015-02-10 Shionogi & Co., Ltd. Heterocyclic compound having type I 11 β hydroxysteroid dehydrogenase inhibitory activity
US7605289B2 (en) 2005-06-17 2009-10-20 Amgen, Inc. Benzamide derivatives and uses related thereto
US20090163549A1 (en) 2005-12-15 2009-06-25 Hiroyuki Kai Pharmaceutical Composition Comprising an Amide Derivative
EA014717B1 (en) * 2006-04-21 2011-02-28 Эли Лилли Энд Компани Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
MY148128A (en) * 2006-04-21 2013-02-28 Lilly Co Eli Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
DK2021337T3 (en) 2006-04-25 2010-03-29 Lilly Co Eli Inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
US7659287B2 (en) 2006-06-08 2010-02-09 Amgen Inc. Benzamide derivatives and uses related thereto
TW200808695A (en) 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
WO2008065500A2 (en) * 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
WO2008088540A2 (en) 2006-12-26 2008-07-24 Amgen Inc. N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
EP2937345B1 (en) 2009-12-29 2018-03-21 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
UA112418C2 (en) 2010-09-07 2016-09-12 Астеллас Фарма Інк. THERAPEUTIC DISEASE
US20140031547A1 (en) 2010-12-14 2014-01-30 Electrophoretics Limited CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES

Also Published As

Publication number Publication date
LT2772484T (en) 2017-12-27
TWI545113B (en) 2016-08-11
IN2014CN02949A (en) 2015-07-03
US9266840B2 (en) 2016-02-23
EP2772484B1 (en) 2017-06-28
US20140249151A1 (en) 2014-09-04
RS56288B1 (en) 2017-12-29
JPWO2013058258A1 (en) 2015-04-02
ZA201403513B (en) 2015-11-25
BR112014009524A2 (en) 2017-05-09
MX344014B (en) 2016-12-02
HRP20171125T1 (en) 2017-10-06
ES2641258T3 (en) 2017-11-08
AU2012327076A1 (en) 2014-05-01
EA201490811A1 (en) 2014-09-30
CN103917524A (en) 2014-07-09
UA112327C2 (en) 2016-08-25
KR101987514B1 (en) 2019-06-10
CA2851589A1 (en) 2013-04-25
CN103917524B (en) 2016-05-04
TW201331185A (en) 2013-08-01
EA024846B1 (en) 2016-10-31
AU2012327076B2 (en) 2017-07-06
WO2013058258A1 (en) 2013-04-25
IL232061A0 (en) 2014-05-28
ME02733B (en) 2017-10-20
AR088378A1 (en) 2014-05-28
EP2772484A1 (en) 2014-09-03
MX2014004701A (en) 2014-10-14
PT2772484T (en) 2017-08-04
IL232061A (en) 2016-04-21
CA2851589C (en) 2019-02-19
CY1119181T1 (en) 2018-03-07
EP2772484A4 (en) 2015-03-25
SI2772484T1 (en) 2017-11-30
KR20140081860A (en) 2014-07-01
JP6020459B2 (en) 2016-11-02
DK2772484T3 (en) 2017-08-21

Similar Documents

Publication Publication Date Title
EP2738170A4 (en) Heterocyclic compound
IL232570B (en) Bicyclic dihydroisoquinoline-1-one derivatives
HK1210769A1 (en) Heterocyclic compound
EP2889291A4 (en) Heterocyclic compound
PT2716642T (en) Imidazopyridine compound
ZA201401577B (en) New bicyclic dihydroquinoline-2-one derivatives
EP2873669A4 (en) Heterocyclic compound
EP2832734A4 (en) Heterocyclic compound
EP2709609A4 (en) Heterocyclic compounds
EP2818473A4 (en) Heterocyclic compound
EP2927229A4 (en) Heterocyclic compound
EP2772485A4 (en) Bicyclic compound
EP2840076A4 (en) Bicyclic compound
EP2857400A4 (en) Heterocyclic compound
EP2794569A4 (en) Heterocyclic urea compounds
ZA201403513B (en) Bicyclic heterocyclic compound
EP2735567A4 (en) Heterocyclic substituted pyrimidine compound
GB201121042D0 (en) Beta-lactam compounds