PL2334677T3 - Triazolopyridine compounds as pim kinase inhibitors - Google Patents
Triazolopyridine compounds as pim kinase inhibitorsInfo
- Publication number
- PL2334677T3 PL2334677T3 PL09791625T PL09791625T PL2334677T3 PL 2334677 T3 PL2334677 T3 PL 2334677T3 PL 09791625 T PL09791625 T PL 09791625T PL 09791625 T PL09791625 T PL 09791625T PL 2334677 T3 PL2334677 T3 PL 2334677T3
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitors
- pim kinase
- triazolopyridine compounds
- triazolopyridine
- compounds
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000008523 triazolopyridines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8995208P | 2008-08-19 | 2008-08-19 | |
| US17527709P | 2009-05-04 | 2009-05-04 | |
| EP09791625.8A EP2334677B1 (en) | 2008-08-19 | 2009-08-18 | Triazolopyridine compounds as pim kinase inhibitors |
| PCT/US2009/054193 WO2010022076A1 (en) | 2008-08-19 | 2009-08-18 | Triazolopyridine compounds as pim kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2334677T3 true PL2334677T3 (en) | 2014-03-31 |
Family
ID=41227138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09791625T PL2334677T3 (en) | 2008-08-19 | 2009-08-18 | Triazolopyridine compounds as pim kinase inhibitors |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8575145B2 (en) |
| EP (1) | EP2334677B1 (en) |
| JP (2) | JP5518072B2 (en) |
| CN (1) | CN102186851B (en) |
| AR (1) | AR073079A1 (en) |
| CA (1) | CA2734831C (en) |
| DK (1) | DK2334677T3 (en) |
| ES (1) | ES2439501T3 (en) |
| HR (1) | HRP20131140T1 (en) |
| PL (1) | PL2334677T3 (en) |
| PT (1) | PT2334677E (en) |
| RS (1) | RS53079B (en) |
| SI (1) | SI2334677T1 (en) |
| SM (1) | SMT201400154B (en) |
| TW (1) | TWI496779B (en) |
| UY (1) | UY32057A (en) |
| WO (1) | WO2010022076A1 (en) |
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| AR059898A1 (en) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| EP3070090B1 (en) | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
| ES2409215T3 (en) | 2007-09-14 | 2013-06-25 | Janssen Pharmaceuticals, Inc. | 1-3-disubstituted 4-phenyl-1H-pyridin-2-ones |
| BRPI0817101A2 (en) | 2007-09-14 | 2017-05-09 | Addex Pharmaceuticals Sa | 1,3-disubstituted 4- (aryl-x-phenyl) -1h-pyridin-2-ones |
| SI2203439T1 (en) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-y1, 4' bipyridinyl-2'-ones |
| ES2637794T3 (en) | 2007-11-14 | 2017-10-17 | Janssen Pharmaceuticals, Inc. | Imidazo [1,2-A] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
| US8987251B2 (en) | 2008-08-19 | 2015-03-24 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
| ES2439291T3 (en) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | 3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors |
| CA2738849C (en) | 2008-10-16 | 2016-06-28 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| ES2401691T3 (en) | 2008-11-28 | 2013-04-23 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxacin derivatives as modulators of metabotropic glutamate receptors |
| SG176018A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
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| ES2440001T3 (en) | 2009-05-12 | 2014-01-27 | Janssen Pharmaceuticals, Inc. | 1,2,4-Triazolo [4,3-A] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| EP3643312A1 (en) | 2009-05-22 | 2020-04-29 | Incyte Holdings Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| AR076794A1 (en) | 2009-05-22 | 2011-07-06 | Incyte Corp | DERIVATIVES OF N- (HETERO) ARIL-PIRROLIDINA DE PIRAZOL-4-IL-PIRROLO [2,3-D] PIRIMIDINES AND PIRROL-3-IL-PIRROLO [2,3-D] PYRIMIDINS AS INHIBITORS OF THE JANUS KINASE AND COMPOSITIONS PHARMACEUTICS THAT CONTAIN THEM |
| AR078012A1 (en) | 2009-09-01 | 2011-10-05 | Incyte Corp | HETEROCICLIC DERIVATIVES OF PIRAZOL-4-IL-PIRROLO (2,3-D) PYRIMIDINS AS INHIBITORS OF THE QUANASA JANUS |
| EP3050882B1 (en) | 2010-03-10 | 2018-01-31 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| SG10201503983QA (en) | 2010-05-21 | 2015-06-29 | Incyte Corp | Topical Formulation for a JAK Inhibitor |
| CN103298809B (en) | 2010-11-08 | 2016-08-31 | 杨森制药公司 | 1,2,4-Triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of the MGLUR2 receptor |
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| PT3773593T (en) | 2018-03-30 | 2024-06-25 | Incyte Corp | TREATMENT OF HIDRADENITIS SUPpurativa WITH JAK INHIBITORS |
| CN117959303A (en) | 2018-04-13 | 2024-05-03 | 住友制药肿瘤公司 | PIM kinase inhibitors for the treatment of myeloproliferative neoplasms and cancer-associated fibrosis |
| KR20210091767A (en) | 2018-11-15 | 2021-07-22 | 니뽄 신야쿠 가부시키가이샤 | 1,3,4-oxadiazolone compounds and medicaments |
| NZ778055A (en) | 2019-02-12 | 2025-11-28 | Sumitomo Pharma America Inc | Formulations comprising heterocyclic protein kinase inhibitors |
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| CN111138429A (en) * | 2019-12-31 | 2020-05-12 | 西安邮电大学 | Synthetic method of 1,2,4-triazolopyridine derivatives |
| CN111171023B (en) * | 2020-01-10 | 2021-12-21 | 中国药科大学 | Compound with Pim1 inhibitory activity and preparation method and medical application thereof |
| CN113620942B (en) * | 2020-05-06 | 2025-02-11 | 北京鼎材科技有限公司 | A compound and its application |
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| EP4611753A1 (en) | 2022-10-31 | 2025-09-10 | Sumitomo Pharma America, Inc. | Pim1 inhibitor for treating myeloproliferative neoplasms |
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-
2009
- 2009-08-14 TW TW098127485A patent/TWI496779B/en not_active IP Right Cessation
- 2009-08-18 US US13/059,902 patent/US8575145B2/en not_active Expired - Fee Related
- 2009-08-18 PL PL09791625T patent/PL2334677T3/en unknown
- 2009-08-18 SI SI200930782T patent/SI2334677T1/en unknown
- 2009-08-18 CA CA2734831A patent/CA2734831C/en not_active Expired - Fee Related
- 2009-08-18 HR HRP20131140AT patent/HRP20131140T1/en unknown
- 2009-08-18 AR ARP090103170A patent/AR073079A1/en active IP Right Grant
- 2009-08-18 WO PCT/US2009/054193 patent/WO2010022076A1/en not_active Ceased
- 2009-08-18 CN CN2009801413028A patent/CN102186851B/en not_active Expired - Fee Related
- 2009-08-18 RS RS20130557A patent/RS53079B/en unknown
- 2009-08-18 EP EP09791625.8A patent/EP2334677B1/en active Active
- 2009-08-18 PT PT97916258T patent/PT2334677E/en unknown
- 2009-08-18 UY UY0001032057A patent/UY32057A/en active IP Right Grant
- 2009-08-18 DK DK09791625.8T patent/DK2334677T3/en active
- 2009-08-18 ES ES09791625.8T patent/ES2439501T3/en active Active
- 2009-08-18 JP JP2011523939A patent/JP5518072B2/en not_active Expired - Fee Related
-
2014
- 2014-03-07 JP JP2014044674A patent/JP2014129409A/en not_active Withdrawn
- 2014-10-21 SM SM201400154T patent/SMT201400154B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2734831A1 (en) | 2010-02-25 |
| SMT201400154B (en) | 2015-01-15 |
| US8575145B2 (en) | 2013-11-05 |
| TW201008940A (en) | 2010-03-01 |
| CN102186851A (en) | 2011-09-14 |
| PT2334677E (en) | 2013-11-26 |
| SI2334677T1 (en) | 2013-12-31 |
| DK2334677T3 (en) | 2013-11-18 |
| CA2734831C (en) | 2017-04-18 |
| US20110144085A1 (en) | 2011-06-16 |
| RS53079B (en) | 2014-06-30 |
| AR073079A1 (en) | 2010-10-13 |
| UY32057A (en) | 2011-01-31 |
| JP5518072B2 (en) | 2014-06-11 |
| HRP20131140T1 (en) | 2014-01-03 |
| EP2334677B1 (en) | 2013-10-09 |
| CN102186851B (en) | 2013-06-12 |
| EP2334677A1 (en) | 2011-06-22 |
| TWI496779B (en) | 2015-08-21 |
| JP2012500277A (en) | 2012-01-05 |
| JP2014129409A (en) | 2014-07-10 |
| ES2439501T3 (en) | 2014-01-23 |
| WO2010022076A1 (en) | 2010-02-25 |
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