PL163235B1 - Biocide for disinfection and protection against microbial decomposition of industrial liquids - Google Patents

Abstract

A biocide for disinfection and protection against microbial decomposition of liquids industrial-containing alkoxy derivative of 1,3,5-hexahydro-s-triazine, characterized in that it is a mixture of 1,3,5-tris (2-hydroxyethyl) -hexahydro-s-triazine with a complex said s-triazine and a metal such as copper, nickel or cobalt, the amount of the complex in the mixture it is from 0.1 to 2%.

Description

The subject of the invention is a biocide for disinfection and protection against decomposition of microbial industrial liquids containing an alkoxy derivative of 1,3,5-hexahhdrooSstriazine. The biocidal properties of αlkholto-hydroxydilyl-, alkyldyalkyl s-traazine derivatives are well known. 1,3,5-tri9 (2-hydroxy-ethyl) -hθktahydro-s-triazineα and the method of its preparation are described by E.M. Snooin ^ and L. Rappoppot in the book '' S-Triaznes and Oeasratirss on pages 486 and 4-8 published in 1959 by Intarscience Publishers Soc NY. The biocidal properties and the use of an elkilo series are known. hydrokkayalyl- and alkokβyaikyl derivatives of 1,3,5-hekydahydrooSstriazines from a number of patents, e.g. from the United States of America, North America, No. 278, 4 033 886. These compounds can exist alone as active substances, but they can also be mixed with other biocidal substances. An adduct of iodine or bromine with 1,3,5-tris (β-hydroxy / ethyl hθxahhdro-triazine) and its use as a bactericide or fungicide is also known from US Pat. Of the United States of America PN No. 3 840 661. ^^ the above-mentioned compounds As biocides, they are used to protect against decomposition of such materials as: chocchillos-8oαru liquids. iron and hydraulic fluids. These substances can also be used to protect paints, especially emulsion paints such as: acrylic, vinyl, larθkaoar and alkyd paints, as well as oil paints, varnishes, adhesives and to protect paper. It can also be used as disinfectants for liquid solids (^ óde, pastes, etc.

The material conditions constitute a suitable environment for the development of microorganisms, which, using them as a source of energy, lead to irreversible changes in their composition and physico-chemical properties. Biocides are commonly used in order to maintain the functional properties of raw materials and protect them against microbial degradation.

Most of the used c ^^ αtzcca biocides of 1,3,5-hak9ahydrooSstriazine derivatives have only bactericidal properties and insufficient fungicidal activity. The use of such agents leads to artificial selection, elimination from the system of bacteria and the aggressive development of mold fungi, yeasts and yeasts and their dominance of the environment. As a result, the biomass is particularly troublesome in industrial systems where oil-water emotions are used. As hydraulic fluids and liquids cool the lubricants. Deposits formed in the systems cause patency in conduits, clogging of felt, valve blocks and manifolds.

The known agent 1,3,5-tris (2-hydroxyethyl) hsksahydro-s-triazine shows an effective bactericidal effect of ratom, and insufficient fungicidal activity, especially against yeasts. The desired fungicidal effect of the agent has so far been obtained by mixing it with other compounds, e.g. 1,2-benzisotlase-3łm-3, creating a biocide called Proxel TN or by forming iodides or bromides.

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During the search for the possibility of extending the action spectrum of 1,3,5-trls / 2 [beta] - [beta] hydroxystyl / hekeahyddroeetriazine, it was found that the tan compound forms stable, highly water-soluble complexes with some metals such as: copper, nickel, cobalt. Unexpectedly, it turned out that these complexes in a mixture with 1,3,5-tria (2-hydrocayethyl) hexahydro-s-trlazine show a much stronger biocidal and especially fungicidal activity compared to 1,3,5-tria (2-hydroxyethyl) ^ hexah ^^ t ^ dc ^ -s ^^ trlj ^^^^ and 1,2-benzisothiazolinera-3-one. These comlexes are easily obtained by mixing 1,3,5-tris- / 2-hydrocβyθtyl- / hexahydro-striazine with aqueous solutions of any of the water-soluble salts listed in μ (81ι. Water-insoluble salts can also be used, aie this is more troublesome, the process takes longer and requires additional heat.

It was found that 1,3,5-tris / 2-Κ ^ ο-13υθ tyło / hexahhddo --- toiazine and metal complex meshes, calculated on the metal content in the amount from 0.1 to 2.0%, showed optimal biocidal activity especially against yeasts and mold fungi. The minimum values of the microbial inhibitory concentration (MIC) obtained experimentally for the agent according to the invention in comparison with 1,3,5-tris. -Hydroxystyl (yek8ahydro-triazine and 1,2-benzisothiazolinim-3oon) and lower c- are presented in Table I .

Table I.

Strain The minimum concentration of hαiuJąie microbial growth / MIC / ppm AND B c Aer ^ monas hydrophila 50 100 75 Alialigenas faecalis 25 75 250 Pseudo-nas terJginoβa 200 250 250 Escheeichia coli 125 125 250 Candida albicans 1000 1500 1250 Aspeegillus niger 1000 > 2000 1000 Chactomium iC ^ c ^ 250 500 500 Fusarium solani 1000 > 2000 1000 Aureobasidium pullulans 1000 > 2000 1500 yeast 1000 > 2000 1750

A - agent according to the invention: 1,3,5-tri9 / 2-hydoxyethyl complex / hθkβahydro - stoiazines with copper / 0.18% Cu /

B - 1,3,5-tris / 2-hydroxystyl / yeksahhdro --- trlazine α

The C-1,2-benzo-zothisholin-3-one agent according to the invention is especially suitable for the protection against microblobic contamination and decomposition of industrial oil and water-based emulsions as cooling lubricants, rolling and hydraulic fluids.

An advantage of the agent according to the invention is that it can be used in conjunction with emulsifying oil concentrates. EmiJsja prepared from such concentrates are protected against microbiological contamination.

an agent of the invention may be used as a base for the drainage of drilling fluids prior to microbial degradation. It can also be an active substance in disinfectants used for disinfection of technological lines and tanks intended for the storage of propellants, oils and greases. The biocidal properties of the agent according to the invention can be used in closed technological water circuits and cooling towers, it can also be used to protect mt ^ ι · skJίih products, dispersion paints, oil paints, varnishes, delortidJz - imlrlgzacdJndch agents for wood. The effectiveness of the measure and the possibility of holding it are illustrated by examples and tab.

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Ex. ad I. A solution of 7.2 g of cupric sulfate pentahydrate in 27 g of water is gradually added with stirring to 965.8 g of 89% technical 1,3,5-trle- (2-hddrokeyethyl) -hexahydroos-triazine. The mixture becomes blue in color, characteristic of copper complexes with amines, and after 10-16 mn. stirring gives a clear blue commercial product. The content of copper kommlesk in the mixture, calculated as copper, is 0.18%.

Example IX. A warm solution of 33.9 g of nickel acetate in 203.1 g of water is gradually added with stirring to 763 g of 84.3% technical 1,3,5-tris (2-hydroxy-ethyl) -, 3,5-hexahydroos-triazine and after a dozen or so minutes of stirring, a clear green solution is obtained, state / more commercial product. The content of the nickel complex in terms of nickel amounts to 0.8%.

Example Ul. A water suspension of k (balrootg) (33.9 g of k (balrootg) formate in 203.1 g of water (33.9 g of water) is added gradually, while stirring, to 763 g of 84.3% of technical 1, while stirring. 3,5-tre - / 2-hrdroSsyθtyro / -l »3, -hhexahydro-3-thiazines. In the heat margin and the momentum the suspension turns into a clear solution, which is a commercial product. The cobalt complex content (including m / m) as converted to cobalt is 1.07%.

Example IV. To evaluate the effectiveness of the biocidal agent of the invention in emulsions of ^L-OWC θ ^r · l / ^a n ch ^e used ^b nlpowoβtrzane of iorni ^path comprising ³⁰⁰⁰ emu en ^ Ji ^d of which is added at 10% uu / Kulum infect. This inoculum consisted of the microflora inhabiting the emuation of the liquid from the hydraulic and cooling system. The contamination level of emu ^ s! The microorganisms were contaminated with direct inoculation on microbial / shanks for 100 days, adding 1% of the tested incubation system at seven-day intervals. tyyiki are presented in Tables I and II.

Table II

Biocidal effectiveness of microbicides against the microflora inhabiting cooling and lubricating liquids

- ------....---- -, Concentration of microblocks Time of complete elimination microorganisms in 5% oil coolant s-1nia- Kommlex [%] meealu w Emm ^ oh! EN [days] mushrooms bacteria yeast i sins I'll convert me tal Cu niu na Ni What I am trembling mold 0.1 0.00021 - - 100 100 100 0.1 - 0.0012 - 100 92 100 0.1 - - 0.0017 100 87 90 0.1 - - - 42 15 21

Table III

Efficacy of bi / bleed microbicides against microflora inhabiting hydraulic fluids st / solnt in hard coal mines.

Concentration of uicrbiocerium Time of complete elimination microorganisms in a 2% emulsion of oil s-v rji- zyns complex conversions Cu metal in iu for meal Emulkop bacteria ^[d niJ yeast-and thrush mushrooms mold Ni What 0, 085 0.00018 - - 100 87 100

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continued Table HI

1 2 3 4 5 6 7 0.085 - 0.0010 - 100 35 100 0.085 - - 0.0010 100 thirty 100 0.085 - - - 42 15 28

EXAMPLE 5 A drilling mud containing 7% b ^ nt ^^ and ^ i-tu 1 2.5% Rotocal starch reagent was contaminated with soil microflora adapted to the mud growth. The initial level of contamination was determined to be 2.10 bacterial cells and 1.10 fungal formation in ¹ cm ³ bins. By ^p osiew ^yellow in ezpośrednic ^{b h p} shelved suitably selected ^from A microbiological specified time required for the total elimination of soil microorganisms in the rinse path depending on which stažení of the invention comprising 0.18% Cu kompileksu. The results are shown in Table III.

Constraints of the agent according to the invention Time required for complete elimination of microorganisms from containing % 0.18% Cu scrubbers days 0.5% 22 1% 15 2% 4 3% 1

Example VI. an agent of the invention containing 0.18% of the Cu complex was added at a concentration of 0.5% to a closed system of industrial water showing a high degree of micro-biological contamination. 1 cm of this water contained 3.10 aerobic bacteria and 2.10 fungi, and the presence of the sulfate-reducing tenne-free batteries was detected. After 2 days of the product's operation, the microflora present in the water was completely eliminated.

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Publishing Department of the UP RP. Circulation of 90 copies

^{000 0} Rate l of ^L

Claims (1)

Patent claim A biocide for disinfection and protection against microbiological decomposition of industrial liquids containing alkoxy of 1,3,5-hexahyddOos-triazine, characterized in that it is a mixture of 1,3,5-tris (2-hydroxyethyl) -h -xαhydro-3-triazine with a complex of this s-traezine and metal such as copper, nickel or cobat, the amount of the complex in the mixture being 0.1 to 2%.