PL1601776T4 - Expression vectors comprising the mcmv ie2 promoter - Google Patents

Expression vectors comprising the mcmv ie2 promoter

Info

Publication number
PL1601776T4
PL1601776T4 PL04718972T PL04718972T PL1601776T4 PL 1601776 T4 PL1601776 T4 PL 1601776T4 PL 04718972 T PL04718972 T PL 04718972T PL 04718972 T PL04718972 T PL 04718972T PL 1601776 T4 PL1601776 T4 PL 1601776T4
Authority
PL
Poland
Prior art keywords
mcmv
promoter
expression vectors
gene
expression
Prior art date
Application number
PL04718972T
Other languages
Polish (pl)
Other versions
PL1601776T3 (en
Inventor
Philippe Chatellard
Markus Imhof
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of PL1601776T3 publication Critical patent/PL1601776T3/en
Publication of PL1601776T4 publication Critical patent/PL1601776T4/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/04—Varicella-zoster virus
    • C07K14/045—Cytomegalovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
    • C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to an expression vector comprising the promoter of the mCMV-IE2 gene, or a functional expression promoting fragment thereof, and/or an enhancer of the mCMV-IE2 gene, or a functional expression enhancing fragment thereof, wherein the expression vector does not contain any complete gene of the mCMV.
PL04718972T 2003-03-11 2004-03-10 Expression vectors comprising the mcmv ie2 promoter PL1601776T4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03100617 2003-03-11
PCT/EP2004/050280 WO2004081167A2 (en) 2003-03-11 2004-03-10 Expression vectors comprising the mcmv ie2 promoter
EP04718972A EP1601776B1 (en) 2003-03-11 2004-03-10 Expression vectors comprising the mcmv ie2 promoter

Publications (2)

Publication Number Publication Date
PL1601776T3 PL1601776T3 (en) 2008-12-31
PL1601776T4 true PL1601776T4 (en) 2009-05-29

Family

ID=32981915

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04718972T PL1601776T4 (en) 2003-03-11 2004-03-10 Expression vectors comprising the mcmv ie2 promoter

Country Status (26)

Country Link
US (3) US7824907B2 (en)
EP (1) EP1601776B1 (en)
JP (3) JP5171033B2 (en)
KR (1) KR101180139B1 (en)
CN (1) CN100429315C (en)
AT (1) ATE399872T1 (en)
AU (1) AU2004219917B2 (en)
BR (1) BRPI0408246A (en)
CA (1) CA2516157C (en)
CY (1) CY1108344T1 (en)
DE (1) DE602004014738D1 (en)
DK (1) DK1601776T3 (en)
EA (1) EA010096B1 (en)
ES (1) ES2309508T3 (en)
HK (1) HK1085766A1 (en)
HR (1) HRP20050705B1 (en)
IL (1) IL170754A (en)
MX (1) MXPA05009608A (en)
NO (1) NO333818B1 (en)
PL (1) PL1601776T4 (en)
PT (1) PT1601776E (en)
RS (1) RS50488B (en)
SI (1) SI1601776T1 (en)
UA (1) UA88138C2 (en)
WO (1) WO2004081167A2 (en)
ZA (1) ZA200506400B (en)

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CN100429315C (en) * 2003-03-11 2008-10-29 雪兰诺实验室有限公司 Expression vectors comprising the MCMV IE2 promoter
JP5074030B2 (en) * 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Activity variants of IL-18 binding protein and their medical applications
ATE484591T1 (en) * 2003-10-21 2010-10-15 Merck Serono Sa MINIMAL DNA SEQUENCE ACTING AS A CHROMATIN INSULATOR AND ITS USE FOR PROTEIN EXPRESSION
PT1689777E (en) 2003-11-05 2007-05-31 Ares Trading Sa Process for the purification of il-18 binding protein
RS50531B (en) * 2004-03-01 2010-05-07 Ares Trading S.A. Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells
EP1761552B1 (en) * 2004-06-29 2008-09-17 Ares Trading S.A. Process for the purification of il-18 binding protein
AU2005311246B2 (en) * 2004-12-02 2010-12-02 Merck Serono Sa The Lupac bifunctional marker and its use in protein production
WO2006111387A2 (en) 2005-04-22 2006-10-26 Lonza Biologics Plc. Mammalian expression vector comprising the mcmv promoter and first intron of hcmv major immediate early gene
AU2006247425A1 (en) * 2005-05-16 2006-11-23 Morphotek, Inc. Regulated vectors for selection of cells exhibiting desired phenotypes
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
JP5091127B2 (en) * 2005-06-10 2012-12-05 アレス トレーディング ソシエテ アノニム Method for purification of IL-18 binding protein
EP1760092A1 (en) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
US20100330572A1 (en) * 2007-12-21 2010-12-30 Assaraf Yehuda G Organic compounds
JP2009276724A (en) * 2008-05-19 2009-11-26 Nitto Denko Corp Method of manufacturing optical waveguide device
PT2401377T (en) 2009-02-27 2016-08-18 Novartis Ag Expression vector system comprising two selection markers
JP5502406B2 (en) * 2009-09-14 2014-05-28 ロンザ・バイオロジクス・ピーエルシー Methods for expressing recombinant proteins in CHO cells
KR101038126B1 (en) * 2010-11-30 2011-05-31 주식회사 엘지생명과학 Novel hybrid promoter and recombinant vector which includes the promoter
US9249785B2 (en) * 2012-01-31 2016-02-02 Brightsource Industries (Isreal) Ltd. Method and system for operating a solar steam system during reduced-insolation events
ES2540753T3 (en) * 2012-09-24 2015-07-13 Lonza Biologics Plc. Expression vectors comprising cytomegalovirus promoter and amplifier chimeric sequences
ITFI20120221A1 (en) * 2012-10-22 2014-04-23 Nuovo Pignone Srl "EXHAUST GAS COLLECTOR AND GAS TURBINE"
WO2014133468A1 (en) * 2013-02-28 2014-09-04 Agency For Science, Technology And Research Chimeric promoters for high gene expression level and stability in mammalian cells
CN103173480B (en) * 2013-03-01 2015-06-24 上海中医药大学附属曙光医院 Method for screening multidrug resistance related microRNA (ribonucleic acid) by using dual-luciferase report genes
CN103173481A (en) * 2013-03-01 2013-06-26 上海中医药大学附属普陀医院 Plasmid vector containing 3'UTR (untranslated regions) sequence of ABCB1 gene and reporter gene as well as construction method and use of plasmid vector
WO2014141037A1 (en) 2013-03-11 2014-09-18 Novartis Ag Method of screening cell clones
LT3027646T (en) * 2013-07-31 2018-09-25 Novartis Ag Novel selection vectors and methods of selecting eukaryotic host cells
CA2934412C (en) 2013-12-20 2024-02-20 Novartis Ag Novel eukaryotic cells and methods for recombinantly expressing a product of interest
ES2758504T3 (en) 2013-12-20 2020-05-05 Novartis Ag Novel eukaryotic cells and methods for recombinantly expressing a product of interest
JP6265020B2 (en) * 2014-04-16 2018-01-24 Jnc株式会社 Evil luciferase catalytic protein mutant gene and its usage
MX368664B (en) 2014-04-29 2019-10-10 Novartis Ag Novel vertebrate cells and methods for recombinantly expressing a polypeptide of interest.
SG11201609639VA (en) * 2014-05-19 2016-12-29 Hoffmann La Roche Method for production of polypeptides
KR20160068558A (en) 2014-12-05 2016-06-15 삼성바이오에피스 주식회사 Fusion Polynucleotide Containing Murine CMV Promoter and Method of Preparing a Polypeptide of Interest Using the Same
EP3265807A1 (en) 2015-03-05 2018-01-10 AB2 Bio SA Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases
EP3283634B1 (en) * 2015-04-14 2019-05-22 Janssen Vaccines & Prevention B.V. Recombinant adenovirus expressing two transgenes with a bidirectional promoter
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JP5074030B2 (en) 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Activity variants of IL-18 binding protein and their medical applications
ATE484591T1 (en) 2003-10-21 2010-10-15 Merck Serono Sa MINIMAL DNA SEQUENCE ACTING AS A CHROMATIN INSULATOR AND ITS USE FOR PROTEIN EXPRESSION
PT1689777E (en) 2003-11-05 2007-05-31 Ares Trading Sa Process for the purification of il-18 binding protein
RS50531B (en) 2004-03-01 2010-05-07 Ares Trading S.A. Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells
EP1761552B1 (en) 2004-06-29 2008-09-17 Ares Trading S.A. Process for the purification of il-18 binding protein
AU2005311246B2 (en) * 2004-12-02 2010-12-02 Merck Serono Sa The Lupac bifunctional marker and its use in protein production
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
JP5091127B2 (en) 2005-06-10 2012-12-05 アレス トレーディング ソシエテ アノニム Method for purification of IL-18 binding protein
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Also Published As

Publication number Publication date
CA2516157C (en) 2012-09-18
EA010096B1 (en) 2008-06-30
US20070258962A1 (en) 2007-11-08
HK1085766A1 (en) 2006-09-01
CA2516157A1 (en) 2004-09-23
US7824907B2 (en) 2010-11-02
RS50488B (en) 2010-03-02
HRP20050705B1 (en) 2013-08-31
JP2015180222A (en) 2015-10-15
JP2012235787A (en) 2012-12-06
KR20050113193A (en) 2005-12-01
SI1601776T1 (en) 2008-10-31
PT1601776E (en) 2008-09-17
UA88138C2 (en) 2009-09-25
WO2004081167A3 (en) 2004-11-04
CN1759184A (en) 2006-04-12
ATE399872T1 (en) 2008-07-15
KR101180139B1 (en) 2012-09-13
ZA200506400B (en) 2006-12-27
EP1601776B1 (en) 2008-07-02
CN100429315C (en) 2008-10-29
WO2004081167A2 (en) 2004-09-23
US9051582B2 (en) 2015-06-09
MXPA05009608A (en) 2006-03-21
EA200501444A1 (en) 2006-02-24
BRPI0408246A (en) 2006-03-01
IL170754A (en) 2010-11-30
JP5171033B2 (en) 2013-03-27
US20110008839A1 (en) 2011-01-13
JP2006520589A (en) 2006-09-14
NO333818B1 (en) 2013-09-23
US20150252383A1 (en) 2015-09-10
NO20054642L (en) 2005-10-10
DE602004014738D1 (en) 2008-08-14
RS20050687A (en) 2007-11-15
HRP20050705A2 (en) 2005-12-31
EP1601776A2 (en) 2005-12-07
PL1601776T3 (en) 2008-12-31
AU2004219917A1 (en) 2004-09-23
DK1601776T3 (en) 2008-10-13
ES2309508T3 (en) 2008-12-16
CY1108344T1 (en) 2014-02-12
JP5848202B2 (en) 2016-01-27
AU2004219917B2 (en) 2008-01-31

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