PL158223B1 - Method for mnufacturing 4-(1-methyl-4-pirperidilidene)-9,10-dihydro--benso(4,5) cyclohepta (1,2) thiophen-10-on - Google Patents
Method for mnufacturing 4-(1-methyl-4-pirperidilidene)-9,10-dihydro--benso(4,5) cyclohepta (1,2) thiophen-10-onInfo
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- PL158223B1 PL158223B1 PL27986589A PL27986589A PL158223B1 PL 158223 B1 PL158223 B1 PL 158223B1 PL 27986589 A PL27986589 A PL 27986589A PL 27986589 A PL27986589 A PL 27986589A PL 158223 B1 PL158223 B1 PL 158223B1
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Abstract
Description
© OPIS PATENTOWY® PL © 158223 © BI© PATENT DESCRIPTION® EN © 158223 © BI
RZECZPOSPOLITAREPUBLIC
POLSKAPOLAND
Numer zgłoszenia: 279865 Filing number: 279865
Urząd Patentowy Rzeczypospolitej Polskiej (33) Data zgłoszenia: 09.06.1989 © IntCl5:Patent Office of the Republic of Poland ( 33 ) Date of filing: 09.06. 1989 © IntCl 5 :
C07D 409/04C07D 409/04
CZIiTElBlA0 Gó LimCZIiTElBlA0 Gó Lim
Sposób wytwarzania 4-/l-metylo-4-piperydylideno/ -9,10-dihydro-4H-benzo [4,5] cyklohepta [1,2] tiofen-10-onuMethod for the preparation of 4- (1-methyl-4-piperidylidene) -9.10-dihydro-4H-benzo [4.5] cyclohepta [1,2] thiophen-10-one
Zgłoszenie ogłoszono:Application announced:
10.12.1990 BUP 25/9010/12/1990 BUP 25/90
O udzieleniu patentu ogłoszono: 31.08.1992 WUP 08/92The grant of the patent was announced on: August 31, 1992, WUP 08/92
Uprawniony z patentu:The holder of the patent:
Warszawskie Zakłady Farmaceutyczne “Polfa”, Warszawa, PLWarsaw Pharmaceutical Works "Polfa", Warsaw, PL
Politechnika Warszawska, Warszawa, PLWarsaw University of Technology, Warsaw, PL
Twórcy wynalazku:Inventors:
Andrzej Jończyk, Warszawa, PL Zbigniew Wróbel, Warszawa, PL Michał Fedoryński, Warszawa, PL Irena Kmiotek-Skarżyriska, Warszawa, PL Wiesława Kiełbasińska, Milanówek, PL Marek Gnyś, Warszawa, PL Andrzej Tyrała, Warszawa, PLAndrzej Jończyk, Warsaw, PL Zbigniew Wróbel, Warsaw, PL Michał Fedoryński, Warsaw, PL Irena Kmiotek-Skarżyriska, Warsaw, PL Wiesława Kiełbasińska, Milanówek, PL Marek Gnyś, Warsaw, PL Andrzej Tyrał, Warsaw, PL
PL 158223 BIPL 158223 BI
1. Sposób wytwarzania 4-(l-metylo-4-piperydylideno)-9,10-dihydro-4H-benzo[4,5]cyklohepta[l,2]tiofen-10-onu o wzorze 1, znamienny tym, że diketon o wzorze 3 poddaje się reakcji ze związkiem Grignarda o wzorze 4, użytym w ilości co najmniej 2 mole na 1 mol diketonu o wzorze 3.1. A process for the preparation of 4- (1-methyl-4-piperidylidene) -9,10-dihydro-4H-benzo [4,5] cyclohepta [1,2] thiophen-10-one of formula 1, characterized in that the diketone 3 is reacted with a Grignard compound of formula 4 used in an amount of at least 2 moles per mole of the diketone of formula 3.
2. Sposób wytwarzania 4-(l-metylo-4-piperydylideno)-9,10-dihydro-4H-benzo[4,5]cyklohepta[l ,2]tiofen-10-onu o wzorze 1, znamienny tym, że diketon o wzorze 3 traktuje się kolejno związkiem Grignarda o wzorze 6, gdzie R, oznacza niższą grupę alkilową, X oznacza atom halogenu, użytym w ilości nie większej niż 1 mol na 1 mol diketonu o wzorze2. A process for the preparation of 4- (1-methyl-4-piperidylidene) -9,10-dihydro-4H-benzo [4,5] cyclohepta [1,2] thiophen-10-one of formula 1, characterized in that the diketone of formula 3 is treated sequentially with a Grignard compound of formula 6, where R, is lower alkyl, X is halogen, used in an amount not greater than 1 mole per 1 mole of the diketone of formula
3, a następnie związkiem Grignarda o wzorze3, followed by a Grignard compound of formula
4, użytym w ilości nie mniejszej niż 1 mol na 1 mol diketonu o wzorze 3.4, used in an amount not less than 1 mole per mole of the diketone of formula 3.
/\.M9CL/\.M 9 CL
WZdR 4 r2h9xWZdR 4 r 2 h 9 x
UZdA iUZdA and
SPOSÓB WYTWARZANIA 4-(1-METYLO-4-PIPERYDYLIDENO)-9,10-DIHYDRO-4H-BENZO /4,5/ CYKLOHEPTA [1,2] TIOFEN-IOoONUMETHOD OF MAKING 4- (1-METHYL-4-PIPERIDYLIDENO) -9.10-DIHYDRO-4H-BENZO / 4.5 / CYCLHEPTA [1.2] THIOPHEN-IOoON
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL27986589A PL158223B1 (en) | 1989-06-09 | 1989-06-09 | Method for mnufacturing 4-(1-methyl-4-pirperidilidene)-9,10-dihydro--benso(4,5) cyclohepta (1,2) thiophen-10-on |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL27986589A PL158223B1 (en) | 1989-06-09 | 1989-06-09 | Method for mnufacturing 4-(1-methyl-4-pirperidilidene)-9,10-dihydro--benso(4,5) cyclohepta (1,2) thiophen-10-on |
Publications (1)
Publication Number | Publication Date |
---|---|
PL158223B1 true PL158223B1 (en) | 1992-08-31 |
Family
ID=20047525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL27986589A PL158223B1 (en) | 1989-06-09 | 1989-06-09 | Method for mnufacturing 4-(1-methyl-4-pirperidilidene)-9,10-dihydro--benso(4,5) cyclohepta (1,2) thiophen-10-on |
Country Status (1)
Country | Link |
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PL (1) | PL158223B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7915249B2 (en) | 2005-01-27 | 2011-03-29 | Janssen Pharmaceutical Nv | Heterocyclic tetracyclic tetrahydrofuran derivatives as 5HT2 inhibitors in the treatment of CNS disorders |
-
1989
- 1989-06-09 PL PL27986589A patent/PL158223B1/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7915249B2 (en) | 2005-01-27 | 2011-03-29 | Janssen Pharmaceutical Nv | Heterocyclic tetracyclic tetrahydrofuran derivatives as 5HT2 inhibitors in the treatment of CNS disorders |
US8404729B2 (en) | 2005-01-27 | 2013-03-26 | Janssen Pharmaceutica, Nv | Heterocyclic tetracyclic tetrahydrofuran derivatives |
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