PL128971B1 - Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons - Google Patents
Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons Download PDFInfo
- Publication number
- PL128971B1 PL128971B1 PL21822379A PL21822379A PL128971B1 PL 128971 B1 PL128971 B1 PL 128971B1 PL 21822379 A PL21822379 A PL 21822379A PL 21822379 A PL21822379 A PL 21822379A PL 128971 B1 PL128971 B1 PL 128971B1
- Authority
- PL
- Poland
- Prior art keywords
- codeine
- solutions
- hydrocarbons
- salts
- mineral acids
- Prior art date
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Description
I, i IV, wkraplano wodny roztwór kwasu ortofosforowego (okolo 40%). Po calkowitym odparo¬ waniu azeotropu woda-toluen, wydzielony fosforan kode¬ iny odsaczono i przemyto acetonem do calkowitego odmycia toluenu. Przemyty produkt wysuszono pod zmniejszonym cisnieniem. Uzyskano fosforan kodeiny o czystosci farmako- pealnej z wydajnoscia 99,7%.Przyklad VI. Doswiadczenie wykonano podobnie jak w przykladzie V z ta róznica, ze zamiast wodnego roz¬ tworu kwasu ortofosforowego wkraplano 80% wodny roztwór kwasu octowego. Odparowywanie azeotropu woda-toluen prowadzono pod zmniejszonym cisnieniem rzedu 9,3 kPa podobnie jak w przykladzie V. Uzyskano octankodeiny o czystosci 99,91 % z wydajnoscia99,5 %. PLI, and IV, an aqueous solution of orthophosphoric acid (about 40%) was added dropwise. After complete evaporation of the water-toluene azeotrope, the precipitated codeine phosphate was filtered off and washed with acetone until the toluene was completely removed. The washed product was dried under reduced pressure. Codeine phosphate of pharmacological purity was obtained with a yield of 99.7%. Example VI. The experiment was carried out similarly to Example 5, except that an 80% aqueous acetic acid solution was added dropwise instead of an aqueous solution of phosphoric acid. The evaporation of the water-toluene azeotrope was carried out under a reduced pressure of 9.3 kPa, similarly to example V. Acetancodeine was obtained with a purity of 99.91% with a yield of 99.5%. PL
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL21822379A PL128971B1 (en) | 1979-09-10 | 1979-09-10 | Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL21822379A PL128971B1 (en) | 1979-09-10 | 1979-09-10 | Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons |
Publications (2)
Publication Number | Publication Date |
---|---|
PL218223A1 PL218223A1 (en) | 1980-07-28 |
PL128971B1 true PL128971B1 (en) | 1984-03-31 |
Family
ID=19998311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL21822379A PL128971B1 (en) | 1979-09-10 | 1979-09-10 | Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL128971B1 (en) |
-
1979
- 1979-09-10 PL PL21822379A patent/PL128971B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL218223A1 (en) | 1980-07-28 |
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