PL128971B1 - Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons - Google Patents

Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons Download PDF

Info

Publication number
PL128971B1
PL128971B1 PL21822379A PL21822379A PL128971B1 PL 128971 B1 PL128971 B1 PL 128971B1 PL 21822379 A PL21822379 A PL 21822379A PL 21822379 A PL21822379 A PL 21822379A PL 128971 B1 PL128971 B1 PL 128971B1
Authority
PL
Poland
Prior art keywords
codeine
solutions
hydrocarbons
salts
mineral acids
Prior art date
Application number
PL21822379A
Other languages
Polish (pl)
Other versions
PL218223A1 (en
Inventor
Ryszard Heropolitanski
Mieczyslaw Wosko
Marian Sykula
Andrzej Kazmierczak
Ryszard Zakowski
Original Assignee
Inst Chemii Przemyslowej
Kutnowskie Zakl Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Chemii Przemyslowej, Kutnowskie Zakl Farma filed Critical Inst Chemii Przemyslowej
Priority to PL21822379A priority Critical patent/PL128971B1/en
Publication of PL218223A1 publication Critical patent/PL218223A1/xx
Publication of PL128971B1 publication Critical patent/PL128971B1/en

Links

Description

I, i IV, wkraplano wodny roztwór kwasu ortofosforowego (okolo 40%). Po calkowitym odparo¬ waniu azeotropu woda-toluen, wydzielony fosforan kode¬ iny odsaczono i przemyto acetonem do calkowitego odmycia toluenu. Przemyty produkt wysuszono pod zmniejszonym cisnieniem. Uzyskano fosforan kodeiny o czystosci farmako- pealnej z wydajnoscia 99,7%.Przyklad VI. Doswiadczenie wykonano podobnie jak w przykladzie V z ta róznica, ze zamiast wodnego roz¬ tworu kwasu ortofosforowego wkraplano 80% wodny roztwór kwasu octowego. Odparowywanie azeotropu woda-toluen prowadzono pod zmniejszonym cisnieniem rzedu 9,3 kPa podobnie jak w przykladzie V. Uzyskano octankodeiny o czystosci 99,91 % z wydajnoscia99,5 %. PLI, and IV, an aqueous solution of orthophosphoric acid (about 40%) was added dropwise. After complete evaporation of the water-toluene azeotrope, the precipitated codeine phosphate was filtered off and washed with acetone until the toluene was completely removed. The washed product was dried under reduced pressure. Codeine phosphate of pharmacological purity was obtained with a yield of 99.7%. Example VI. The experiment was carried out similarly to Example 5, except that an 80% aqueous acetic acid solution was added dropwise instead of an aqueous solution of phosphoric acid. The evaporation of the water-toluene azeotrope was carried out under a reduced pressure of 9.3 kPa, similarly to example V. Acetancodeine was obtained with a purity of 99.91% with a yield of 99.5%. PL

Claims (3)

Zastrzezenia patentowe 1. Sposób otrzymywania soli kodeiny, glównie kwasów mineralnych z roztworów kodeiny w weglowodorach przez dzialanie na te roztwory wodnymi roztworami kwasów, znamienny tym, ze do roztworu kodeiny w weglowodorze, ogrzanym do temperatury wyzszej o kilka lub kilkanascie stopni od temperatury wrzenia azeotropuwoda — stosowany weglowodór, dozuje sie przy ciaglym mieszaniu wodny roztwór kwasu mineralnego lub organicznego o ilosci wegli do C6, a nastepnie po calkowitym azeotropowym oddestylowaniu wody wydziela sie sól kodeiny znanym spo¬ sobem.Claims 1. A method of obtaining codeine salts, mainly mineral acids, from codeine solutions in hydrocarbons by treating these solutions with aqueous acid solutions, characterized in that a solution of codeine in hydrocarbon heated to a temperature higher by a few or a dozen degrees higher than the boiling point of azeotrope in water - the hydrocarbon used is metered in with constant stirring an aqueous solution of a mineral or organic acid with a carbon amount of up to C6, and then, after complete azeotropic distillation of the water, the codeine salt is released in a known manner. 2. Sposób wedlug zastrz. 1, znamienny tym, ze proces prowadzi sie pod zmniejszonym cisnieniem.2. The method according to claim The process of claim 1, wherein the process is carried out under reduced pressure. 3. Sposób wedlug zastrz. 1, znamienny tym, ze jako kwas organiczny stosuje sie kwas winowy. LDD Z-d 2, £. 261/1400/85/60, n. M+20 egZ. Cena 100 xl PL3. The method according to p. The process of claim 1, wherein the organic acid is tartaric acid. LDD Z-d 2, £. 261/1400/85/60, n. M + 20 ex. Price 100 xl PL
PL21822379A 1979-09-10 1979-09-10 Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons PL128971B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL21822379A PL128971B1 (en) 1979-09-10 1979-09-10 Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL21822379A PL128971B1 (en) 1979-09-10 1979-09-10 Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons

Publications (2)

Publication Number Publication Date
PL218223A1 PL218223A1 (en) 1980-07-28
PL128971B1 true PL128971B1 (en) 1984-03-31

Family

ID=19998311

Family Applications (1)

Application Number Title Priority Date Filing Date
PL21822379A PL128971B1 (en) 1979-09-10 1979-09-10 Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons

Country Status (1)

Country Link
PL (1) PL128971B1 (en)

Also Published As

Publication number Publication date
PL218223A1 (en) 1980-07-28

Similar Documents

Publication Publication Date Title
SU572201A3 (en) Method of preparing methyl ester of 5-propyltio-2-benzimidazolcarbamic acid
DE69221858D1 (en) METHOD FOR RECOVERY OF PURIFIED TEREPHTALIC ACID
IE832129L (en) Process for the preparation of sulfonated aryl phosphines
ES481060A1 (en) Process for the preparation of dustless, readily-dispersible pigment or dyestuff granules
FI800729A (en) FOERFARANDE FOER OMVANDLING AV FOSFORSYRA TILL FASTA AVFALLSPRODUKTER
PL128971B1 (en) Process for preparing codeine salts,especially with mineral acids from solutions of codeine in hydrocarbons
IE800208L (en) Production of isosorbide-5-nitrate
KR900007859A (en) Method for preparing N-acyl-aminomethyl phosphonate
DE2555183C3 (en) Process for the preparation of p-nitrobenzyl-7-phenoxy- and -7-phenylacetamidodeacetoxycephalosporanate
DE2329957C3 (en) Method of cleaning glyoxal
US1976923A (en) Amino-alkyl-esters of the carboxy-alkoxy-amino-diphenyls
GB862396A (en) A method for the preparation of hydrazine derivatives of phosphoric and thiophosphoric acids
SU698921A1 (en) Method of preparing porous chromium phosphate
US3342868A (en) 1,1,2,2-tetraformylethane, its preparation and its salts
JP2731816B2 (en) Cresol purification method
SU108267A1 (en) The method of obtaining paranitrobenzaldehyde
SU704945A1 (en) Method of isolating powdered polyvinylacetate
SU487890A1 (en) Method for chlorpromazine release
US1665236A (en) Process for obtaining furane derivatives
JPH0390047A (en) Production of 3,5-dialkylsalicylic acid
SU1065410A1 (en) Process for preparing 2-amino-5-tert-alkyl-1,3,4-thiadiazoles
GB687986A (en) Improvements in or relating to the dehydration of castor oil
GB872311A (en) A process for the manufacture of di-imidazole derivatives
SU745893A1 (en) Method of preparing 2,2-dichloropropionic acid powest aliphatic esters
Fox et al. Reaction of Salts of Organophosphorus Acids with Isocyanates