PH30109A - Triazolylthiomethylthio cephalosporin hydroclhloride its crystalline hydrate and the production of the same - Google Patents
Triazolylthiomethylthio cephalosporin hydroclhloride its crystalline hydrate and the production of the sameInfo
- Publication number
- PH30109A PH30109A PH46601A PH46601A PH30109A PH 30109 A PH30109 A PH 30109A PH 46601 A PH46601 A PH 46601A PH 46601 A PH46601 A PH 46601A PH 30109 A PH30109 A PH 30109A
- Authority
- PH
- Philippines
- Prior art keywords
- production
- crystalline hydrate
- triazolylthiomethylthio
- hydroclhloride
- cephalosporin
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
7 beta -[(Z)-2-(2-Amino 4 thiazolyl)-2-hydroxyiminoacetamido]-3-(1,2,3-triazol-4-yl)thiomethylth io-3-cephem-4-carboxylic acid hydrochloride and its crystalline hydrate, which have a potent antibiotic activity and are low toxic and pharmaceutically stable, thereby useful as an active ingredient of clinically useful antibiotic formulations, and the production thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20496592 | 1992-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
PH30109A true PH30109A (en) | 1996-12-27 |
Family
ID=16499234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH46601A PH30109A (en) | 1992-07-31 | 1993-07-29 | Triazolylthiomethylthio cephalosporin hydroclhloride its crystalline hydrate and the production of the same |
Country Status (23)
Country | Link |
---|---|
US (1) | US5407929A (en) |
EP (1) | EP0581552B1 (en) |
KR (1) | KR100245938B1 (en) |
CN (1) | CN1037683C (en) |
AT (1) | ATE165360T1 (en) |
AU (1) | AU657866B2 (en) |
BR (1) | BR9303235A (en) |
CA (1) | CA2101502A1 (en) |
DE (1) | DE69318077T2 (en) |
ES (1) | ES2115725T3 (en) |
FI (1) | FI933391A (en) |
GR (1) | GR3026699T3 (en) |
HU (1) | HU219637B (en) |
IL (1) | IL106516A (en) |
MX (1) | MX9304611A (en) |
NO (1) | NO303734B1 (en) |
NZ (1) | NZ248285A (en) |
PH (1) | PH30109A (en) |
PL (2) | PL172835B1 (en) |
RU (1) | RU2118959C1 (en) |
TW (1) | TW307769B (en) |
UA (1) | UA37181C2 (en) |
ZA (1) | ZA935529B (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU230382B1 (en) * | 2001-02-24 | 2016-03-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivative, production and use thereof as a medicament |
AT413282B (en) * | 2002-02-01 | 2006-01-15 | Sandoz Ag | CRYSTALLINE SALTS OF 7 - (((5-AMINO-1,2,4-THIADIAZOL-3-YL) (FLUOROMETHOXY-IMINO) ACETYL) AMINO) -3- ((IMINO-1-PIPERAZINYLMETHYL) |
KR20030076759A (en) * | 2002-03-21 | 2003-09-29 | 주식회사 엘지생명과학 | Novel cephalosporin compounds and process for preparing same |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
DE202004021379U1 (en) | 2003-02-12 | 2008-02-21 | Ciba Specialty Chemicals Holding Inc. | Crystalline forms of pitivastatin calcium |
WO2004085444A1 (en) | 2003-03-27 | 2004-10-07 | Basilea Pharmaceutica Ag | Cephalosporin in crystalline form |
US7501426B2 (en) * | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (en) * | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines |
DE102005035891A1 (en) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8- (3-amino-piperidin-1-yl) -xanthines, their preparation and their use as pharmaceuticals |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
NZ619413A (en) | 2006-05-04 | 2015-08-28 | Boehringer Ingelheim Int | Polymorphs of a dpp-iv enzyme inhibitor |
PE20110235A1 (en) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | PHARMACEUTICAL COMBINATIONS INCLUDING LINAGLIPTIN AND METMORPHINE |
ES2733348T3 (en) * | 2007-08-17 | 2019-11-28 | Boehringer Ingelheim Int | Purine derivatives for use in the treatment of diseases related to FAP |
AR071175A1 (en) * | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | PHARMACEUTICAL COMPOSITION THAT INCLUDES AN INHIBITOR OF DIPEPTIDIL-PEPTIDASA-4 (DPP4) AND A COMPARING PHARMACO |
PE20100156A1 (en) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | NAFLD TREATMENT |
KR20190016601A (en) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | Treatment for diabetes in patients inappropriate for metformin therapy |
UY32030A (en) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "TREATMENT FOR DIABETES IN INAPPROPRIATE PATIENTS FOR THERAPY WITH METFORMIN" |
CA2735562C (en) * | 2008-08-15 | 2017-10-17 | Boehringer Ingelheim International Gmbh | Dpp-4 inhibitors for wound healing |
RU2011113823A (en) | 2008-09-10 | 2012-10-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | COMBINED THERAPY FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
JP2012512848A (en) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Salt forms of organic compounds |
AR074990A1 (en) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | TREATMENT OF DIABETES IN PATIENTS WITH AN INAPPROPRIATE GLUCEMIC CONTROL THROUGH METFORMIN THERAPY |
JP2013512229A (en) | 2009-11-27 | 2013-04-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Treatment of diabetic patients whose genotype has been identified with DDP-IV inhibitors such as linagliptin |
BR112012028136A2 (en) | 2010-05-05 | 2016-08-09 | Boehringer Ingelheim Int | combination therapy |
EP3725325B1 (en) | 2010-06-24 | 2023-05-31 | Boehringer Ingelheim International GmbH | Diabetes therapy |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
CN103781788B (en) | 2011-07-15 | 2016-08-17 | 勃林格殷格翰国际有限公司 | Quinazoline, its preparation and the purposes in pharmaceutical composition thereof being substituted |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
MX2018015089A (en) | 2016-06-10 | 2019-05-13 | Boehringer Ingelheim Int | Combinations of linagliptin and metformin. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE65926B1 (en) * | 1990-07-19 | 1995-11-29 | Shionogi & Co | Thioalkylthio cephalosporin derivatives |
-
1993
- 1993-07-26 ES ES93305864T patent/ES2115725T3/en not_active Expired - Lifetime
- 1993-07-26 DE DE69318077T patent/DE69318077T2/en not_active Expired - Fee Related
- 1993-07-26 TW TW082105942A patent/TW307769B/zh active
- 1993-07-26 EP EP93305864A patent/EP0581552B1/en not_active Expired - Lifetime
- 1993-07-26 AT AT93305864T patent/ATE165360T1/en not_active IP Right Cessation
- 1993-07-27 US US08/097,205 patent/US5407929A/en not_active Expired - Fee Related
- 1993-07-27 UA UA93003172A patent/UA37181C2/en unknown
- 1993-07-28 IL IL106516A patent/IL106516A/en not_active IP Right Cessation
- 1993-07-28 HU HU9302194A patent/HU219637B/en not_active IP Right Cessation
- 1993-07-28 AU AU44227/93A patent/AU657866B2/en not_active Ceased
- 1993-07-28 CA CA002101502A patent/CA2101502A1/en not_active Abandoned
- 1993-07-29 FI FI933391A patent/FI933391A/en unknown
- 1993-07-29 PH PH46601A patent/PH30109A/en unknown
- 1993-07-29 PL PL93299870A patent/PL172835B1/en unknown
- 1993-07-29 NZ NZ24828593A patent/NZ248285A/en unknown
- 1993-07-29 PL PL93317972A patent/PL172830B1/en unknown
- 1993-07-30 MX MX9304611A patent/MX9304611A/en unknown
- 1993-07-30 KR KR1019930014742A patent/KR100245938B1/en not_active IP Right Cessation
- 1993-07-30 NO NO932745A patent/NO303734B1/en unknown
- 1993-07-30 BR BR9303235A patent/BR9303235A/en not_active Application Discontinuation
- 1993-07-30 RU RU93047027/04A patent/RU2118959C1/en not_active IP Right Cessation
- 1993-07-30 ZA ZA935529A patent/ZA935529B/en unknown
- 1993-07-31 CN CN93117437A patent/CN1037683C/en not_active Expired - Fee Related
-
1998
- 1998-04-23 GR GR980400753T patent/GR3026699T3/en unknown
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