PH26728A - The use of certain lactam derivatives in the treatment of depression - Google Patents
The use of certain lactam derivatives in the treatment of depression Download PDFInfo
- Publication number
- PH26728A PH26728A PH39185A PH39185A PH26728A PH 26728 A PH26728 A PH 26728A PH 39185 A PH39185 A PH 39185A PH 39185 A PH39185 A PH 39185A PH 26728 A PH26728 A PH 26728A
- Authority
- PH
- Philippines
- Prior art keywords
- compound
- formula
- group
- hydrogen atom
- methyl
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims description 13
- 208000020401 Depressive disease Diseases 0.000 title claims description 7
- 150000003951 lactams Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 43
- 239000004480 active ingredient Substances 0.000 claims description 20
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 19
- -1 phenyl- methoxymethyl Chemical group 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 239000012453 solvate Substances 0.000 claims description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 241000282414 Homo sapiens Species 0.000 claims description 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888820653A GB8820653D0 (en) | 1988-09-01 | 1988-09-01 | Medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26728A true PH26728A (en) | 1992-09-28 |
Family
ID=10643005
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH39186A PH26985A (en) | 1988-09-01 | 1989-08-31 | Medicaments |
| PH39185A PH26728A (en) | 1988-09-01 | 1989-08-31 | The use of certain lactam derivatives in the treatment of depression |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH39186A PH26985A (en) | 1988-09-01 | 1989-08-31 | Medicaments |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0357414A3 (da) |
| JP (1) | JPH02180822A (da) |
| KR (1) | KR900004341A (da) |
| AU (1) | AU627770B2 (da) |
| CA (1) | CA1330535C (da) |
| DK (1) | DK432889A (da) |
| GB (1) | GB8820653D0 (da) |
| IL (1) | IL91481A0 (da) |
| PH (2) | PH26985A (da) |
| ZA (1) | ZA896674B (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5276050A (en) * | 1989-08-01 | 1994-01-04 | Glaxo Group Limited | Medicaments |
| GB0305553D0 (en) * | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR871809B (en) * | 1986-11-28 | 1988-03-07 | Glaxo Group Ltd | Process for the preparation of tricyclic ketones |
| GB8630071D0 (en) * | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
| JPS63277622A (ja) * | 1986-12-17 | 1988-11-15 | グラクソ、グループ、リミテッド | 医薬 |
| NZ226032A (en) * | 1987-09-03 | 1991-12-23 | Glaxo Group Ltd | 2-(imidazolylmethyl)-pyrido or-azepino(4,3-b)indole-1(2h)-one derivatives; preparatory processes and pharmaceutical compositions |
-
1988
- 1988-09-01 GB GB888820653A patent/GB8820653D0/en active Pending
-
1989
- 1989-08-31 AU AU40968/89A patent/AU627770B2/en not_active Ceased
- 1989-08-31 EP EP89308804A patent/EP0357414A3/en not_active Withdrawn
- 1989-08-31 KR KR1019890012467A patent/KR900004341A/ko not_active Application Discontinuation
- 1989-08-31 ZA ZA896674A patent/ZA896674B/xx unknown
- 1989-08-31 PH PH39186A patent/PH26985A/en unknown
- 1989-08-31 IL IL91481A patent/IL91481A0/xx unknown
- 1989-08-31 JP JP1226379A patent/JPH02180822A/ja active Pending
- 1989-08-31 DK DK432889A patent/DK432889A/da unknown
- 1989-08-31 PH PH39185A patent/PH26728A/en unknown
- 1989-08-31 CA CA000609995A patent/CA1330535C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA896674B (en) | 1990-06-27 |
| AU627770B2 (en) | 1992-09-03 |
| JPH02180822A (ja) | 1990-07-13 |
| EP0357414A2 (en) | 1990-03-07 |
| KR900004341A (ko) | 1990-04-12 |
| PH26985A (en) | 1992-12-28 |
| DK432889D0 (da) | 1989-08-31 |
| IL91481A0 (en) | 1990-04-29 |
| DK432889A (da) | 1990-03-02 |
| AU4096889A (en) | 1990-03-08 |
| EP0357414A3 (en) | 1990-06-13 |
| CA1330535C (en) | 1994-07-05 |
| GB8820653D0 (en) | 1988-10-05 |
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