PH20457A - Sorbinil by optical resolution with aminopinane derivatives - Google Patents

Sorbinil by optical resolution with aminopinane derivatives

Info

Publication number
PH20457A
PH20457A PH29803A PH29803A PH20457A PH 20457 A PH20457 A PH 20457A PH 29803 A PH29803 A PH 29803A PH 29803 A PH29803 A PH 29803A PH 20457 A PH20457 A PH 20457A
Authority
PH
Philippines
Prior art keywords
sorbinil
optical resolution
aminopinane
derivatives
salt
Prior art date
Application number
PH29803A
Inventor
Robert John Sysko
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PH20457A publication Critical patent/PH20457A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Physical Water Treatments (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Control Of Turbines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)

Abstract

Sorbinil is obtained by optical resolution of racemic 2,3-dihydrospiro-6-fluoro[4H-I-benzopyran-4,4 min -imidazolidine]-2 min ,5 min -S HY# dione either (a) by direct resolution via the (-)-3-aminomethylpinane salt of sorbinil or (b) by a double resolving agent technique via a mother liquor concentrate of either the (+)-3-aminomethylpinane or the (-)-2-amino-2-norpinane salt of sorbinil, followed by the quinine salt of sorbinil.
PH29803A 1982-11-10 1983-11-09 Sorbinil by optical resolution with aminopinane derivatives PH20457A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44068682A 1982-11-10 1982-11-10

Publications (1)

Publication Number Publication Date
PH20457A true PH20457A (en) 1987-01-14

Family

ID=23749769

Family Applications (1)

Application Number Title Priority Date Filing Date
PH29803A PH20457A (en) 1982-11-10 1983-11-09 Sorbinil by optical resolution with aminopinane derivatives

Country Status (8)

Country Link
EP (1) EP0109231B1 (en)
AT (1) ATE23046T1 (en)
CA (1) CA1202310A (en)
DE (1) DE3367103D1 (en)
HU (1) HU188383B (en)
IE (1) IE56212B1 (en)
PH (1) PH20457A (en)
RO (1) RO87830A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620019A (en) * 1984-08-23 1986-10-28 Pfizer Inc. S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
US5006657A (en) * 1988-07-27 1991-04-09 Pfizer Inc. Intermediates in a resolution process for racemic spiro hydantoins
US4952694A (en) * 1988-07-27 1990-08-28 Pfizer Inc. Novel resolution process for racemic spiro-hydantoins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177282A (en) * 1977-05-23 1979-12-04 Pfizer Inc. Hydantoin therapeutic agents

Also Published As

Publication number Publication date
ATE23046T1 (en) 1986-11-15
IE832618L (en) 1984-05-10
DE3367103D1 (en) 1986-11-27
EP0109231A1 (en) 1984-05-23
CA1202310A (en) 1986-03-25
IE56212B1 (en) 1991-05-22
HU188383B (en) 1986-04-28
EP0109231B1 (en) 1986-10-22
RO87830A2 (en) 1985-12-20
RO87830B1 (en) 1985-12-02

Similar Documents

Publication Publication Date Title
OA06914A (en) Process for the preparation of substituted iminodiacides.
GB8716803D0 (en) Optical isomers
MX18879A (en) ANALOGS OF THE PROSTAGLANDINA OF HETEROCICLICA AMIDA SUBSTITUTED WITH 7-OXABICICLOHEPTILO.
ES510888A0 (en) "PROCEDURE FOR THE PRODUCTION OF 1-ARYL-2-AZOLYLETHENE DERIVATIVES".
NO820581L (en) MACHINE FOR THE PREPARATION OF CARBON ACID DRINK
NO882476D0 (en) PROCEDURE FOR INSTALLATION OF A BODY FRAME ON THE SEA.
ES2086065T3 (en) PREPARATION OF SUBSTITUTED TETRAHIDROPIRIDINAS.
NO884533D0 (en) PROCEDURE FOR PREPARING DERIVATIVES OF THE 2,2-DIMETHYL CHROME.
DE3367103D1 (en) Sorbinil by optical resolution with aminopinane derivatives
CA2030346A1 (en) Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds
IT8223157A0 (en) TOOLMAN'S LATHE.
NO171912C (en) PROCEDURE FOR THE PREPARATION OF 5-CHLORO-3-CHLOROSULPHONYL-2-THIOPHENCARBOXYL ACID ESTERS
NO158254C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF BICYCLO (3,2,1) OCTAN CARBOXYLIC ACID DERIVATIVES.
DE3588208D1 (en) Cephalosporin derivatives
ES507350A0 (en) PROCEDURE FOR THE PREPARATION OF NEW BICYCLE DERIVATIVES (2.2.1) HEPTANES.
AU520059B2 (en) "3-oxa bicyclo (3-1-0) hexan-2-one derivatives
OA06879A (en) Process for the preparation of heteroprostaglandin derivatives.
NO166617C (en) PROCEDURE FOR THE PREPARATION OF INJECTABLE OXYTETRA TRACYCLINE SOLUTIONS.
OA08918A (en) Process for the enrichment of canallite by flotation.
YU60288A (en) Process for obtaining 5-hydroxydiprafenone and its additional salts with acids
PT74274A (en) PROCESS FOR THE PREPARATION OF AMINO-4-BUTYRAMIDE
ES2080286T3 (en) PROCEDURE FOR THE PREPARATION OF PIRIDINADICARBOXILATOS SUBSTITUTED WITH FLUOROMETILO.
ES523125A0 (en) "PROCEDURE FOR PRODUCING DERIVATIVES OF N-PHOSPHONOMETILGLICINA".
FR2541279B1 (en) DERIVATIVES OF 1-AZA-7-OXO-BICYCLO (3.2.0) -HEPT-2-ENE-2-CARBOXYLIC ACID
IT8020991A0 (en) PROCEDURE FOR THE QUALITY CONTROL OF DRILLING MUD.