PH15574A - Pharmaceutical compositions containing 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)pyridine-3-(b-methoxy ethyl ester)-5-(isopropyl ester)and method of use thereof - Google Patents

Pharmaceutical compositions containing 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)pyridine-3-(b-methoxy ethyl ester)-5-(isopropyl ester)and method of use thereof

Info

Publication number
PH15574A
PH15574A PH22376A PH22376A PH15574A PH 15574 A PH15574 A PH 15574A PH 22376 A PH22376 A PH 22376A PH 22376 A PH22376 A PH 22376A PH 15574 A PH15574 A PH 15574A
Authority
PH
Philippines
Prior art keywords
nitrophenyl
dihydro
pyridine
dimethyl
pharmaceutical compositions
Prior art date
Application number
PH22376A
Other languages
English (en)
Inventor
Horst Meyer
Friedrich Bossert
Stanislav Kazda
Friedrich Hoffmeister
Wulf Vater
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6036687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH15574(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PH15574A publication Critical patent/PH15574A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
PH22376A 1978-04-11 1979-04-10 Pharmaceutical compositions containing 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)pyridine-3-(b-methoxy ethyl ester)-5-(isopropyl ester)and method of use thereof PH15574A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2815578A DE2815578C2 (de) 1978-04-11 1978-04-11 Neue pharmazeutische Verwendung von Nimodipin

Publications (1)

Publication Number Publication Date
PH15574A true PH15574A (en) 1983-02-17

Family

ID=6036687

Family Applications (1)

Application Number Title Priority Date Filing Date
PH22376A PH15574A (en) 1978-04-11 1979-04-10 Pharmaceutical compositions containing 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)pyridine-3-(b-methoxy ethyl ester)-5-(isopropyl ester)and method of use thereof

Country Status (27)

Country Link
US (1) US4406906A (nl)
EP (1) EP0004650B1 (nl)
JP (3) JPS54135776A (nl)
AT (1) AT383271B (nl)
AU (1) AU532623B2 (nl)
BE (1) BE875457A (nl)
CA (1) CA1140853A (nl)
CH (3) CH640734A5 (nl)
DE (2) DE2815578C2 (nl)
DK (1) DK150479A (nl)
ES (1) ES479474A1 (nl)
FI (1) FI791162A (nl)
FR (1) FR2422402A1 (nl)
GB (1) GB2018134A (nl)
GR (1) GR71463B (nl)
HK (1) HK59188A (nl)
IE (1) IE51651B1 (nl)
IL (1) IL57030A (nl)
IT (1) IT1062201B (nl)
LU (2) LU88273I2 (nl)
NL (2) NL7902778A (nl)
NO (1) NO791009L (nl)
NZ (1) NZ190133A (nl)
PH (1) PH15574A (nl)
SE (1) SE447248B (nl)
SG (1) SG18688G (nl)
ZA (1) ZA791728B (nl)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0078430B2 (de) * 1981-10-29 1993-02-10 Bayer Ag Verfahren zur Herstellung von festen, schnellfreisetzenden Arzneizubereitungen mit Dihydropyridinen
DE3142853A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung
JPS58172312A (ja) * 1982-04-02 1983-10-11 Toa Eiyou Kagaku Kogyo Kk ニフエジピン外用剤
JPS58177916A (ja) * 1982-04-13 1983-10-18 Kowa Co 外用剤
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds
DE3316510A1 (de) * 1983-05-06 1984-11-08 Bayer Ag Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
FR2568773B1 (fr) * 1984-08-10 1989-03-03 Sandoz Lab Nouvelles compositions pharmaceutiques administrables par voie nasale
EP0175671A1 (de) * 1984-08-23 1986-03-26 Kuhlemann & Co. Pharmazeutische Zubereitung sowie Verfahren zum Darreichen dieser pharmazeutischen Zubereitung
DE3438830A1 (de) * 1984-10-23 1986-04-30 Rentschler Arzneimittel Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
US4758669A (en) * 1986-05-05 1988-07-19 Radiation Oncology Center Research And Development Corporation 4-(nitrone aryl) dihydropyridines
US5401759A (en) * 1989-11-16 1995-03-28 Miles Inc. Nimodipine enhanced growth and vascularization of neural grafts
RU1804845C (ru) * 1991-02-15 1993-03-30 Институт Органического Синтеза Латвийской Ан Ноотропное вещество
JP2793410B2 (ja) * 1991-04-22 1998-09-03 インターナショナル・ビジネス・マシーンズ・コーポレイション ウェブ駆動装置及びテープ駆動装置
US5438144A (en) * 1991-07-30 1995-08-01 Troponwerke Gmbh & Co. Kg Use of 1,4-dihydropyridines in diabetes
DE4130173A1 (de) * 1991-09-11 1993-03-18 Bayer Ag Pharmazeutische zubereitungen mit einer speziellen kristallmodifikation des 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarbonsaeure-isopropyl-(2-methoxyethyl)-esters
DE4133257A1 (de) * 1991-10-08 1993-04-15 Bayer Ag N-methyl-nimodipin, verfahren zu seiner herstellung und seine verwendung als zerebraltherapeutikum
IT1255792B (it) * 1992-08-05 1995-11-16 Bayer Italia Spa Composizioni farmaceutiche per la somministrazione orale di diidropiridine in forma di bevanda
US6001857A (en) * 1992-10-30 1999-12-14 Bayer Aktiengesellschaft Heterocyclyl substituted dihydropyridines
DK0595164T3 (da) * 1992-10-30 1997-05-26 Bayer Ag 4-Heterocyclophenyl-substituerede dihydropyridiner
DE4236707A1 (de) * 1992-10-30 1994-05-05 Bayer Ag 4-Heterocyclyl substituierte Dihydropyridine
SE9203857D0 (sv) * 1992-12-22 1992-12-22 Astra Ab Use of an enantiomeric dihydropyridine
DE4342193A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Arylsubstituierte Alkoxycarbonyl-1,4-dihydropyridin-5-carbonsäureester
ES2193148T3 (es) 1993-12-10 2003-11-01 Bayer Ag 1,4-dihidropiridinas sustituidas con fenilo con actividad cerebral.
EE03192B1 (et) * 1993-12-10 1999-06-15 Bayer Aktiengesellschaft Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine
DE4430094A1 (de) * 1994-08-25 1996-02-29 Bayer Ag Verwendung von 3,5-Dicarbonsäureester-1,4-Dihydropyridinen als Arzneimittel
US6078481A (en) * 1998-06-08 2000-06-20 Imation Corp. Tape storage cartridge having two-level tape path
AR027152A1 (es) * 2000-12-29 2003-03-12 Osmotica Argentina S A Composicion farmaceutica para el tratamiento de la enfermedad cerebrovascular cognitiva.
DE10142417A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Arzneimittel
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
EP1933837A4 (en) * 2005-10-14 2009-07-15 Transform Pharmaceuticals Inc PHARMACEUTICAL LIQUID COMPOSITIONS OF NIMODIPIN
US8748648B2 (en) * 2007-09-06 2014-06-10 Nektar Therapeutics Oligomer-calcium channel blocker conjugates
US9737478B2 (en) * 2009-09-28 2017-08-22 National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR) Treatment of malaria

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
GB1430961A (en) * 1972-01-22 1976-04-07 Yamanouchi Pharma Co Ltd 1-substituted-1,4-dihyddrypyridine derivatives
GB1455502A (en) * 1973-02-20 1976-11-10 Yamanouchi Pharma Co Ltd 1,4-dihydropyridine derivatives

Also Published As

Publication number Publication date
ES479474A1 (es) 1979-12-16
IL57030A (en) 1982-09-30
FR2422402A1 (fr) 1979-11-09
FR2422402B1 (nl) 1982-07-02
HK59188A (en) 1988-08-12
EP0004650A1 (de) 1979-10-17
NL7902778A (nl) 1979-10-15
SE7903186L (sv) 1979-10-12
US4406906A (en) 1983-09-27
IT7921692A0 (it) 1979-04-09
NO791009L (no) 1979-10-12
SE447248B (sv) 1986-11-03
CA1140853A (en) 1983-02-08
AT383271B (de) 1987-06-10
IE51651B1 (en) 1987-02-04
JPS58219117A (ja) 1983-12-20
NZ190133A (en) 1985-02-28
JPS54135776A (en) 1979-10-22
DE2815578A1 (de) 1979-10-18
DK150479A (da) 1979-10-12
SG18688G (en) 1989-07-07
LU81133A1 (de) 1979-11-07
DE2815578C2 (de) 1986-01-16
JPS591412A (ja) 1984-01-06
JPS5730089B2 (nl) 1982-06-26
CH649468A5 (de) 1985-05-31
IT1062201B (it) 1983-07-29
GR71463B (nl) 1983-05-30
EP0004650B1 (de) 1986-01-29
AU4583579A (en) 1979-10-18
GB2018134A (en) 1979-10-17
DE2967573D1 (en) 1986-03-13
BE875457A (fr) 1979-10-10
NL930034I2 (nl) 1993-10-01
AU532623B2 (en) 1983-10-06
IE790756L (en) 1979-10-11
CH649921A5 (de) 1985-06-28
ZA791728B (en) 1980-05-28
FI791162A (fi) 1979-10-12
IL57030A0 (en) 1979-07-25
ATA262179A (de) 1986-11-15
CH640734A5 (de) 1984-01-31
LU88273I2 (nl) 1994-02-03
NL930034I1 (nl) 1993-08-02

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