PE72599A1 - SELECTIVE CARPROPHEN FOR COX-2, FOR THE TREATMENT OF PAIN AND INFLAMMATION IN DOGS - Google Patents
SELECTIVE CARPROPHEN FOR COX-2, FOR THE TREATMENT OF PAIN AND INFLAMMATION IN DOGSInfo
- Publication number
- PE72599A1 PE72599A1 PE1998000335A PE00033598A PE72599A1 PE 72599 A1 PE72599 A1 PE 72599A1 PE 1998000335 A PE1998000335 A PE 1998000335A PE 00033598 A PE00033598 A PE 00033598A PE 72599 A1 PE72599 A1 PE 72599A1
- Authority
- PE
- Peru
- Prior art keywords
- cox
- alkyl
- carprophen
- phenyl
- dogs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA COMPOSICION PARA EL TRATAMIENTO O PREVENCION DEL DOLOR, PROCESOS Y ENFERMEDADES INFLAMATORIAS EN PERROS, ASOCIADOS CON LA ACTIVIDAD DE LA CICLOOXIGENASA-2 (COX-2) REDUCIENDO O ELIMINANDO LOS EFECTOS INDESEABLES ASOCIADOS CON LA INHIBICION DE LA ACTIVIDAD DE LA CICLOOXIGENASA-1 (COX-1); LA RELACION DE SELECTIVIDAD DE COX 2:COX 1 ES DE 3:1; EL INHIBIDOR ES UN COMPUESTO, DE FORMULA I, DONDE: R2 ES UN COMPUESTO DE FORMULA (a), A ES HIDROXI, ALCOXI C1-C4, AMINO, ENTRE OTROS; R6 ES HALOGENO, ALQUILO C1-C3, TRIFLUOROMETILO O NITRO; R9 ES H, ALQUILO C1-C2, FENILO O FENIL-ALQUILO C1-C2, FENILO OPCIONALMENTE SUSTITUIDO CON F, Cl, -C(=O)R; R ES ALQUILO C1-C2 O FENILO; "X" E "Y" SON H, ALQUILO C1-C2 Y DEFINEN ENANTIOMEROS (-)(R) Y (+)(S), DE PREFERENCIA CARPROFENO ACIDO-6-CLORO-ALFA-METIL-9H-CARBAZOL-2-ACETICO, SUS SALES. EL INHIBIDOR CARPROFENO SE PUEDE USAR JUNTO CON UNO O MAS AGENTES TERAPEUTICAMENTE ACTIVOS COMO ANTIBIOTICOS, ANTIFUNGICOS, ANTIPROTOZOOS, ANTIVIRALES Y OTROS INHIBIDORES DE LA INFLAMACIONREFERS TO A COMPOSITION FOR THE TREATMENT OR PREVENTION OF PAIN, PROCESSES AND INFLAMMATORY DISEASES IN DOGS, ASSOCIATED WITH THE ACTIVITY OF CYCLOOXYGENASE-2 (COX-2) REDUCING OR ELIMINATING THE INITIABLE EFFECTS ASSOCIATED WITH INATIO INATIO -1 (COX-1); THE COX 2: COX 1 SELECTIVITY RATIO IS 3: 1; THE INHIBITOR IS A COMPOUND, OF FORMULA I, WHERE: R2 IS A COMPOUND OF FORMULA (a), A IS HYDROXY, ALCOXI C1-C4, AMINO, AMONG OTHERS; R6 IS HALOGEN, C1-C3 ALKYL, TRIFLUOROMETILE OR NITRO; R9 IS H, C1-C2 ALKYL, PHENYL OR PHENYL-C1-C2-ALKYL, PHENYL OPTIONALLY SUBSTITUTED FOR F, Cl, -C (= O) R; R IS C1-C2 ALKYL OR PHENYL; "X" E "Y" ARE H, ALKYL C1-C2 AND DEFINE ENANTIOMERS (-) (R) Y (+) (S), OF PREFERENCE CARPROPHEN ACID-6-CHLORINE-ALPHA-METHYL-9H-CARBAZOL-2- ACETICO, ITS SALTS. THE CARPROPHEN INHIBITOR CAN BE USED TOGETHER WITH ONE OR MORE THERAPEUTICALLY ACTIVE AGENTS AS ANTIBIOTICS, ANTIFUNGALS, ANTIPROTOZOES, ANTIVIRALS AND OTHER INFLAMMATION INHIBITORS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4563597P | 1997-05-05 | 1997-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE72599A1 true PE72599A1 (en) | 1999-08-12 |
Family
ID=21939053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998000335A PE72599A1 (en) | 1997-05-05 | 1998-05-04 | SELECTIVE CARPROPHEN FOR COX-2, FOR THE TREATMENT OF PAIN AND INFLAMMATION IN DOGS |
Country Status (32)
Country | Link |
---|---|
EP (1) | EP0988034A1 (en) |
JP (1) | JP2000513020A (en) |
KR (2) | KR20010012300A (en) |
CN (1) | CN1255059A (en) |
AP (1) | AP9801234A0 (en) |
AR (2) | AR011726A1 (en) |
AU (1) | AU6932198A (en) |
BG (1) | BG103852A (en) |
BR (1) | BR9808720A (en) |
CA (1) | CA2288759A1 (en) |
DZ (1) | DZ2479A1 (en) |
EA (1) | EA003696B1 (en) |
GT (1) | GT199800063A (en) |
HR (1) | HRP980244A2 (en) |
HU (1) | HUP0001286A3 (en) |
ID (1) | ID21311A (en) |
IL (1) | IL132570A0 (en) |
IS (1) | IS5220A (en) |
MA (1) | MA26491A1 (en) |
NO (1) | NO995389L (en) |
NZ (1) | NZ500183A (en) |
OA (1) | OA11213A (en) |
PA (1) | PA8450601A1 (en) |
PE (1) | PE72599A1 (en) |
PL (1) | PL337003A1 (en) |
SK (1) | SK148199A3 (en) |
TN (1) | TNSN98059A1 (en) |
TW (1) | TW590773B (en) |
UY (1) | UY24989A1 (en) |
WO (1) | WO1998050033A1 (en) |
YU (1) | YU55899A (en) |
ZA (1) | ZA983722B (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6245797B1 (en) | 1997-10-22 | 2001-06-12 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease |
AU2003204888B2 (en) * | 1998-05-22 | 2005-07-28 | Pfizer Products Inc. | Treating or Preventing the Early Stages of Degeneration of Articular Cartilage or Subchondral Bone in Mammals Using Carprofen and Derivatives |
US6506785B2 (en) * | 1998-05-22 | 2003-01-14 | Pfizer, Inc. | Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives |
CA2347365A1 (en) * | 1998-10-23 | 2000-05-04 | Merck Frosst Canada & Co. | Combination product comprising an e-type prostaglandin ligand and a cox-2 selective inhibitor and methods of use |
DE60023119T2 (en) * | 1999-03-10 | 2006-07-20 | G.D. Searle Llc | COMPOSITIONS FOR THE ADMINISTRATION OF A CYCLOOXYGENASE-2 HEMMER TO ANIMALS |
WO2001034204A1 (en) * | 1999-11-11 | 2001-05-17 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
WO2001087343A2 (en) * | 2000-05-15 | 2001-11-22 | Merck Frosst Canada & Co. | Combination therapy using cox-2 selective inhibitor and thromboxane inhibitor and compositions therefor |
PL206268B1 (en) | 2000-06-13 | 2010-07-30 | Wyethwyeth | Analgesic and anti-inflammatory compositions containing cox-2 inhibitors |
DE10032132A1 (en) * | 2000-07-01 | 2002-01-17 | Lohmann Therapie Syst Lts | Dermal therapeutic system containing non-steroidal anti-inflammatory drugs with selective COX-2 inhibition |
EP1307585B1 (en) | 2000-08-07 | 2009-01-21 | Vanderbilt University | Compositions and methods for detecting and quantifying cox-2 activity and 2-arachidonylglycerol metabolites |
WO2003007875A2 (en) * | 2001-07-16 | 2003-01-30 | Hoegestaett Edward | Compounds with analgesic, antipyretic and/or anti-inflammatory activity |
ES2275218T3 (en) | 2003-05-07 | 2007-06-01 | Osteologix A/S | HYDROSOLUBLE STRONTIUM SALTS FOR THE TREATMENT OF CARTILAGOS AND / OR BONE AFFECTIONS. |
MXPA06001288A (en) * | 2003-07-31 | 2006-04-11 | Upjohn Co | Dispersible formulation of an anti-inflammatory agent. |
EA200702280A1 (en) * | 2005-05-20 | 2008-04-28 | Пфайзер Лимитед | SYNERGISTIC COMBINATIONS |
JP2010523554A (en) | 2007-04-04 | 2010-07-15 | シグモイド・ファーマ・リミテッド | Pharmaceutical composition of tacrolimus |
US8951570B2 (en) | 2007-04-26 | 2015-02-10 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
GB2483815B (en) | 2009-05-18 | 2013-12-25 | Sigmoid Pharma Ltd | Composition comprising oil drops |
CN107582526A (en) | 2009-08-12 | 2018-01-16 | 希格默伊德药业有限公司 | Immune regulation composite comprising polymer substrate and oil phase |
GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
CN105939713A (en) | 2014-03-06 | 2016-09-14 | 阿莱塔纳治疗学股份有限公司 | Compositions of grapiprant and methods for using same |
AU2015341695B2 (en) | 2014-11-07 | 2021-07-08 | Sublimity Therapeutics Limited | Compositions comprising cyclosporin |
WO2016112312A1 (en) * | 2015-01-09 | 2016-07-14 | Jaguar Animal Health | Methods of treating diarrhea in companion animals |
WO2021195346A1 (en) * | 2020-03-25 | 2021-09-30 | Sri International | Lipoxygenase inhibitors |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
KR102404883B1 (en) | 2020-11-30 | 2022-06-07 | (주)이노보테라퓨틱스 | Pharmaceutical composition for preventing or treating keloid or hypertrophic scar comprising Benzbromarone |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3896145A (en) * | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
CA1319886C (en) * | 1987-02-03 | 1993-07-06 | Alberto Ferro | Mixed micelle solutions |
-
1998
- 1998-03-02 DZ DZ980089A patent/DZ2479A1/en active
- 1998-04-30 TW TW087106689A patent/TW590773B/en not_active IP Right Cessation
- 1998-05-01 ID IDP980651A patent/ID21311A/en unknown
- 1998-05-01 HU HU0001286A patent/HUP0001286A3/en unknown
- 1998-05-01 WO PCT/IB1998/000662 patent/WO1998050033A1/en not_active Application Discontinuation
- 1998-05-01 YU YU55899A patent/YU55899A/en unknown
- 1998-05-01 SK SK1481-99A patent/SK148199A3/en unknown
- 1998-05-01 JP JP10547869A patent/JP2000513020A/en active Pending
- 1998-05-01 NZ NZ500183A patent/NZ500183A/en unknown
- 1998-05-01 CN CN98804845A patent/CN1255059A/en active Pending
- 1998-05-01 PL PL98337003A patent/PL337003A1/en unknown
- 1998-05-01 EP EP98915041A patent/EP0988034A1/en not_active Withdrawn
- 1998-05-01 AU AU69321/98A patent/AU6932198A/en not_active Abandoned
- 1998-05-01 IL IL13257098A patent/IL132570A0/en unknown
- 1998-05-01 KR KR1019997010252A patent/KR20010012300A/en not_active Application Discontinuation
- 1998-05-01 KR KR10-2003-7005258A patent/KR20040004406A/en not_active Application Discontinuation
- 1998-05-01 BR BR9808720-7A patent/BR9808720A/en not_active IP Right Cessation
- 1998-05-01 CA CA002288759A patent/CA2288759A1/en not_active Abandoned
- 1998-05-01 EA EA199900895A patent/EA003696B1/en not_active IP Right Cessation
- 1998-05-04 AP APAP/P/1998/001234A patent/AP9801234A0/en unknown
- 1998-05-04 GT GT199800063A patent/GT199800063A/en unknown
- 1998-05-04 PE PE1998000335A patent/PE72599A1/en not_active Application Discontinuation
- 1998-05-04 UY UY24989A patent/UY24989A1/en not_active Application Discontinuation
- 1998-05-04 MA MA25059A patent/MA26491A1/en unknown
- 1998-05-04 TN TNTNSN98059A patent/TNSN98059A1/en unknown
- 1998-05-04 ZA ZA9803722A patent/ZA983722B/en unknown
- 1998-05-05 AR ARP980102089A patent/AR011726A1/en unknown
- 1998-05-05 HR HR60/045,635A patent/HRP980244A2/en not_active Application Discontinuation
- 1998-05-05 PA PA19988450601A patent/PA8450601A1/en unknown
-
1999
- 1999-10-19 IS IS5220A patent/IS5220A/en unknown
- 1999-11-02 OA OA9900242A patent/OA11213A/en unknown
- 1999-11-03 BG BG103852A patent/BG103852A/en unknown
- 1999-11-04 NO NO995389A patent/NO995389L/en not_active Application Discontinuation
-
2003
- 2003-04-09 AR ARP030101251A patent/AR039628A2/en unknown
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Legal Events
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FC | Refusal |