PE52699A1 - COMPOUNDS AND METHODS TO PREPARE SUBSTITUTED 4-PHENYL-4-CIANO-CYCLOHEXANOIC ACIDS - Google Patents

COMPOUNDS AND METHODS TO PREPARE SUBSTITUTED 4-PHENYL-4-CIANO-CYCLOHEXANOIC ACIDS

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Publication number
PE52699A1
PE52699A1 PE00009798A PE00009798A PE52699A1 PE 52699 A1 PE52699 A1 PE 52699A1 PE 00009798 A PE00009798 A PE 00009798A PE 00009798 A PE00009798 A PE 00009798A PE 52699 A1 PE52699 A1 PE 52699A1
Authority
PE
Peru
Prior art keywords
cr4r5
halogen
substituted
compounds
ciano
Prior art date
Application number
PE00009798A
Other languages
Spanish (es)
Inventor
Ann Marie Diederich
Andrew Allen
Li Lui
Wilford Mendelson
Kevin Webb
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE52699A1 publication Critical patent/PE52699A1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN METODO PARA PRODUCIR UN COMPUESTO DE FORMULA (I), DONDE R1 ES (CR4R5)nCOO(CR4R5)mR6, (CR4R5)n(CONR4), (CR4R5)rR6, ENTRE OTROS; SUSTITUIDOS OPCIONALMENTE CON UNO O MAS HALOGENOS; m ES 0-2, n ES 1-4, r ES 0-6, R4 Y R5 SON INDEPENDIENTEMENTE H O ALQUILO C1-C2; R6 ES H, METILO, OH, ARILO, ENTRE OTROS, SI R6 ES OH, m ES 2 o r ES 2-6 o SI R6 ES 2-TETRAHIDROPIRANILO, 2-TETRAHIDROFURANILO, ENTRE OTROS, m ES 1-2 o r ES 1-6; X ES YR2, HALOGENO, NH2 O FORMILAMINA; X2 ES O o NR8; Y ES O � S(O)m`, m' ES 0-2; R2 ES CH3, NO2 o CH2CH3 SUSTITUIDOS CON UNO O MAS HALOGENOS; R3 ES H, HALOGENO, ALQUILO C1-C4, -CH=CR8'R8', NR8R10, CH2NR8R10, C(Z')H, ENTRE OTROS; R8 ES H, ALQUILO C1-C4 SUSTITUIDO CON 1-3 F; R8' ES R8 o F; R10 ES OR8 o R11; R11 ES H o ALQUILO C1-C4 SUSTITUIDO CON 1-3 F; Z' ES O, NR9, NOR8, NCN, ENTRE OTROS; R'Y R'' SON H o COOH. EL METODO COMPRENDE TRATAR UN COMPUESTO DE FORMULA (II) CON BROMURO DE LITIO EN UN DISOLVENTE POLAR A UNA TEMPERATURA ENTRE 60�C-100�C OPCIONALMENTE EN UNA ATMOSFERA INERTE. TAMBIEN SE REFIERE A LOS COMPUESTOS INTERMEDIOS DE FORMULA (II)IT REFERS TO A METHOD FOR PRODUCING A COMPOUND OF FORMULA (I), WHERE R1 IS (CR4R5) nCOO (CR4R5) mR6, (CR4R5) n (CONR4), (CR4R5) rR6, AMONG OTHERS; OPTIONALLY SUBSTITUTED WITH ONE OR MORE HALOGEN; m ES 0-2, n ES 1-4, r ES 0-6, R4 AND R5 ARE INDEPENDENTLY H OR C1-C2 ALKYL; R6 IS H, METHYL, OH, ARYL, AMONG OTHERS, IF R6 IS OH, m IS 2 or ES 2-6 or IF R6 IS 2-TETRAHYDROPYRANYL, 2-TETRAHYDROFURANYL, AMONG OTHERS, m IS 1-2 or IS 1- 6; X IS YR2, HALOGEN, NH2 OR FORMYLAMINE; X2 IS O or NR8; AND IT'S O � S (O) m`, m 'ES 0-2; R2 IS CH3, NO2 or CH2CH3 SUBSTITUTED WITH ONE OR MORE HALOGEN; R3 IS H, HALOGEN, C1-C4-ALKYL, -CH = CR8'R8 ', NR8R10, CH2NR8R10, C (Z') H, AMONG OTHERS; R8 IS H, C1-C4 ALKYL SUBSTITUTED FOR 1-3 F; R8 'IS R8 or F; R10 IS OR8 or R11; R11 IS H or C1-C4 ALKYL SUBSTITUTED FOR 1-3 F; Z 'ES O, NR9, NOR8, NCN, AMONG OTHERS; R'Y R '' ARE H or COOH. THE METHOD INCLUDES TREATING A FORMULA (II) COMPOUND WITH LITHIUM BROMIDE IN A POLAR SOLVENT AT A TEMPERATURE BETWEEN 60 � C-100 � C OPTIONALLY IN AN INERT ATMOSPHERE. ALSO REFERS TO INTERMEDIATE COMPOUNDS OF FORMULA (II)

PE00009798A 1997-02-12 1998-02-10 COMPOUNDS AND METHODS TO PREPARE SUBSTITUTED 4-PHENYL-4-CIANO-CYCLOHEXANOIC ACIDS PE52699A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3706897P 1997-02-12 1997-02-12

Publications (1)

Publication Number Publication Date
PE52699A1 true PE52699A1 (en) 1999-07-14

Family

ID=49585873

Family Applications (1)

Application Number Title Priority Date Filing Date
PE00009798A PE52699A1 (en) 1997-02-12 1998-02-10 COMPOUNDS AND METHODS TO PREPARE SUBSTITUTED 4-PHENYL-4-CIANO-CYCLOHEXANOIC ACIDS

Country Status (1)

Country Link
PE (1) PE52699A1 (en)

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