PE43497A1 - NEW CRYPTOFICINES FROM THE SYNTHESIS - Google Patents
NEW CRYPTOFICINES FROM THE SYNTHESISInfo
- Publication number
- PE43497A1 PE43497A1 PE00015596A PE00015596A PE43497A1 PE 43497 A1 PE43497 A1 PE 43497A1 PE 00015596 A PE00015596 A PE 00015596A PE 00015596 A PE00015596 A PE 00015596A PE 43497 A1 PE43497 A1 PE 43497A1
- Authority
- PE
- Peru
- Prior art keywords
- link
- amino acid
- subunit
- replaced
- refers
- Prior art date
Links
Abstract
SE REFIERE A LA CRIPTOFICINA DE FORMULA (I), DONDE: AR ES FENIL O CUALQUIER GRUPO SIMPLE AROMATICO O HETEROAROMATICO, SUSTITUIDO O NO; R1 ES HALOGENO O SH, ENTRE OTROS; R2 ES 0H O SH; R1 Y R2 PUEDEN SER UNIDOS Y FORMAR UN ANILLO EPOXIDO,AZIRIDENO,ENTRE OTROS, O FORMAR ENLACE ENTRE C18 Y C19; R3, R8, R9, R10 ES ALQUILO MENOR; R4 Y R5 SON H O FORMAN ENLACE ENTRE C13 Y C14; R6 ES BENCILO, ALCOXIBENCILO, HALOHIDROXIBENCILO, ENTRE OTROS; R7 ES H,ALQUILO MENOR; X e Y SON O, NH O ALQULAMINO. TAMBIEN SE REFIERE AL METODO DE OBTENCION, QUE COMPRENDE: A)SELECCION DEL ALQUENO " E " SUSTITUIDO ALILCALMENTE; B)REORGANIZACION ESTEREOESPECIFICA DE WITTIG, AL ALQUENO; C)CONVERSION A �-AMINOACIDO O ACIDO �-HIDROXI; D)ENLACE A UN �-AMINOACIDO PARA FORMAR UNA PRIMERA SUBUNIDAD; E)ENLACE DE UN �-AMINOACIDO A UN O-HIDRO O O-AMINOACIDO PARA FORMAR UNA SEGUNDA SUBUNIDAD; Y F)ENLACE DE LAS DOS SUBUNIDADES PARA FORMAR UNA CRIPTOFICINA DE FORMULA (I); QUE ACTUA ALTERANDO LA DINAMICA DE LA POLIMERIZACION, INHIBIENDO LA HIPERPROLIFERACION DE CELULAS MAMIFERAS, QUE PUEDEN SER HUMANAS. SE REFIERE ADEMAS, QUE SE ADMINISTRA CON UN AGENTE ANTINEOPLASICO ADICIONAL EN CASOS DE NEOPLASMASIT REFERS TO THE FORMULA CRYPTOPHINE (I), WHERE: AR IS A PHENYL OR ANY SIMPLE AROMATIC OR HETEROAROMATIC GROUP, REPLACED OR NOT; R1 IS HALOGEN OR SH, AMONG OTHERS; R2 is 0H or SH; R1 AND R2 MAY BE UNITED AND FORM AN EPOXIDE RING, AZIRIDENE, AMONG OTHERS, OR FORM A LINK BETWEEN C18 AND C19; R3, R8, R9, R10 IS MINOR ALKYL; R4 AND R5 ARE H OR FORM A LINK BETWEEN C13 AND C14; R6 IS BENCILO, ALCOXIBENCILO, HALOHIDROXIBENCILO, AMONG OTHERS; R7 IS H, MINOR ALKYL; X and Y ARE O, NH OR ALQULAMINO. IT ALSO REFERS TO THE METHOD OF OBTAINING, WHICH INCLUDES: A) SELECTION OF THE ALKENE "E" ALILCALLY REPLACED; B) STEREO-SPECIFIC REORGANIZATION OF WITTIG, ALQUENE; C) CONVERSION TO �-AMINO ACID OR �-HYDROXY ACID; D) LINK TO AN �-AMINO ACID TO FORM A FIRST SUBUNIT; E) LINK OF AN �-AMINO ACID TO AN O-HYDRO OR O-AMINO ACID TO FORM A SECOND SUBUNIT; AND F) LINK OF THE TWO SUBUNITES TO FORM A CRYPTOFIC OF FORMULA (I); THAT ACT ALTERING THE DYNAMICS OF POLYMERIZATION, INHIBITING THE HYPERPROLIFERATION OF MAMMAL CELLS, WHICH MAY BE HUMAN. IT IS ALSO REFERRED TO BE ADMINISTERED WITH AN ADDITIONAL ANTHINEOPLASTIC AGENT IN CASES OF NEOPLASMAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/400,057 US6013626A (en) | 1993-12-21 | 1995-03-07 | Cryptophycins from synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE43497A1 true PE43497A1 (en) | 1997-10-11 |
Family
ID=23582070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE00015596A PE43497A1 (en) | 1995-03-07 | 1996-03-07 | NEW CRYPTOFICINES FROM THE SYNTHESIS |
Country Status (10)
| Country | Link |
|---|---|
| AR (1) | AR003111A1 (en) |
| BR (1) | BR9600952A (en) |
| CO (1) | CO4700444A1 (en) |
| IL (1) | IL117302A (en) |
| IN (1) | IN185695B (en) |
| PE (1) | PE43497A1 (en) |
| RU (1) | RU2195458C2 (en) |
| TR (1) | TR199600191A2 (en) |
| TW (1) | TW458972B (en) |
| ZA (1) | ZA961745B (en) |
-
1996
- 1996-02-28 IL IL11730296A patent/IL117302A/en not_active IP Right Cessation
- 1996-02-29 AR ARP960101585A patent/AR003111A1/en not_active Application Discontinuation
- 1996-03-04 ZA ZA9601745A patent/ZA961745B/en unknown
- 1996-03-06 CO CO96010869A patent/CO4700444A1/en unknown
- 1996-03-06 IN IN454DE1996 patent/IN185695B/en unknown
- 1996-03-07 PE PE00015596A patent/PE43497A1/en not_active Application Discontinuation
- 1996-03-07 TR TR96/00191A patent/TR199600191A2/en unknown
- 1996-03-07 RU RU97116510/04A patent/RU2195458C2/en not_active IP Right Cessation
- 1996-03-07 TW TW85102778A patent/TW458972B/en not_active IP Right Cessation
- 1996-03-07 BR BR9600952A patent/BR9600952A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW458972B (en) | 2001-10-11 |
| CO4700444A1 (en) | 1998-12-29 |
| BR9600952A (en) | 1997-12-30 |
| IL117302A0 (en) | 1996-06-18 |
| ZA961745B (en) | 1997-10-06 |
| IN185695B (en) | 2001-04-07 |
| AR003111A1 (en) | 1998-07-08 |
| RU2195458C2 (en) | 2002-12-27 |
| IL117302A (en) | 2005-03-20 |
| TR199600191A2 (en) | 1996-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |