PE42495A1 - MUTANT PHOSPHENOLPIRUVATE CARBOXYLASE, ITS GENE AND PRODUCTION METHOD FOR AMINO ACID - Google Patents

MUTANT PHOSPHENOLPIRUVATE CARBOXYLASE, ITS GENE AND PRODUCTION METHOD FOR AMINO ACID

Info

Publication number
PE42495A1
PE42495A1 PE1994249156A PE24915694A PE42495A1 PE 42495 A1 PE42495 A1 PE 42495A1 PE 1994249156 A PE1994249156 A PE 1994249156A PE 24915694 A PE24915694 A PE 24915694A PE 42495 A1 PE42495 A1 PE 42495A1
Authority
PE
Peru
Prior art keywords
lysine
glutamic acid
amino acid
replace
arginine
Prior art date
Application number
PE1994249156A
Other languages
Spanish (es)
Inventor
Matsui Hiroshi
Suzuki Tomoko
Sugimoto Masakazu
Izui Katsura
Original Assignee
Suzuki Sanei Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzuki Sanei Co Ltd filed Critical Suzuki Sanei Co Ltd
Publication of PE42495A1 publication Critical patent/PE42495A1/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REFIERE A UNA CARBOXILASA DE FOSFOENOLPIRUVATO MUTANTE QUE ES INSENSIBLE A LA INHIBICION POR RETROALIMENTACION MEDIADA POR ACIDO ASPARTICO, CONSISTIENDO LA MUTACION EN EL CAMBIO DE UN AMINOACIDO, CONTADO A PARTIR DEL TERMINAL N DE LA CARBOXILASA DE FOSFOENOLPIRUVATO, TAL COMO: 1) REEMPLAZAR EL ACIDO GLUTAMICO DE LA POSICION 625 POR LISINA; 2) REEMPLAZAR LA ARGININA 222 POR HISTIDINA Y EL ACIDO GLUTAMICO 223 POR LISINA; 3) REEMPLAZAR LA SERINA 288 POR FENILALANINA, EL ACIDO GLUTAMICO 289 POR LISINA, LA METIONINA 551 POR ISOLEUCINA Y EL ACIDO GLUTAMICO 804 POR LISINA; 4) REEMPLAZAR LA ALANINA 867 POR TREONINA; 5) REEMPLAZAR LA ARGININA 438 POR CISTEINA; 6) REEMPLAZAR LA LISINA 620 POR SERINA, SE REFIERE TAMBIEN AL SEGMENTO DE DNA QUE CODIFICA PARA DICHA ENZIMA Y A UN MICROORGANISMO PERTENECIENTE AL GENERO ESCHERICHIA O AL GRUPO DE BACTERIAS CORENIFORMES QUE CONTIENEN DICHO SEGMENTO DE DNA Y PUEDEN SER UTILIZADAS, MEDIANTE CULTIVO EN UN MEDIO NUTRITIVO ADECUADO, EN LA PRODUCCION DE UN AMINOACIDO TAL COMO LISINA, TREONINA, METIONINA, ISOLEUCINA, ACIDO GLUTAMICO, ARGININA Y PROLINAREFERS TO A MUTANT PHOSPHOENOLPYRUVATE CARBOXYLASE THAT IS INSENSITIVE TO INHIBITION BY FEEDBACK MEDIATED BY ASPARTIC ACID, CONSISTING OF THE MUTATION IN THE CHANGE OF AN AMINO ACID, TAKEN FROM THE CARBOXA N TERMINAL: GLUTAMIC ACID POSITION 625 BY LYSINE; 2) REPLACE ARGININE 222 FOR HISTIDINE AND GLUTAMIC ACID 223 FOR LYSINE; 3) REPLACE SERINE 288 FOR PHENYLALANINE, GLUTAMIC ACID 289 FOR LYSINE, METIONIN 551 FOR ISOLEUCIN AND GLUTAMIC ACID 804 FOR LYSINE; 4) REPLACE ALANINE 867 WITH TREONIN; 5) REPLACE ARGININE 438 WITH CYSTEINE; 6) REPLACING LYSINE 620 WITH SERINE, ALSO REFERS TO THE DNA SEGMENT THAT CODES FOR SUCH ENZYMES AND TO A MICROORGANISM BELONGING TO THE GENUS ESCHERICHIA OR TO THE GROUP OF CORENIFORM BACTERIA, WHICH HAVE SUCH SERIES OF DNA AND MEDIUM MAY, SUITABLE NUTRITIOUS, IN THE PRODUCTION OF AN AMINO ACID SUCH AS LYSINE, THREONINE, METHIONINE, ISOLEUCINE, GLUTAMIC ACID, ARGININE AND PROLINE

PE1994249156A 1993-08-24 1994-08-24 MUTANT PHOSPHENOLPIRUVATE CARBOXYLASE, ITS GENE AND PRODUCTION METHOD FOR AMINO ACID PE42495A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20977593 1993-08-24

Publications (1)

Publication Number Publication Date
PE42495A1 true PE42495A1 (en) 1996-01-03

Family

ID=52272715

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994249156A PE42495A1 (en) 1993-08-24 1994-08-24 MUTANT PHOSPHENOLPIRUVATE CARBOXYLASE, ITS GENE AND PRODUCTION METHOD FOR AMINO ACID

Country Status (1)

Country Link
PE (1) PE42495A1 (en)

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FD Application declared void or lapsed