PE36395A1 - Phenylthiophenyl cycloalkenyl hydroxyurea - Google Patents

Phenylthiophenyl cycloalkenyl hydroxyurea

Info

Publication number
PE36395A1
PE36395A1 PE1994256818A PE25681894A PE36395A1 PE 36395 A1 PE36395 A1 PE 36395A1 PE 1994256818 A PE1994256818 A PE 1994256818A PE 25681894 A PE25681894 A PE 25681894A PE 36395 A1 PE36395 A1 PE 36395A1
Authority
PE
Peru
Prior art keywords
hydrogen
phenylthiophenyl
hydroxyurea
cycloalkenyl
halogen
Prior art date
Application number
PE1994256818A
Other languages
Spanish (es)
Inventor
Rodney W Stevens
Akiyoshi Kawai
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE36395A1 publication Critical patent/PE36395A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: 1) A y B SON HIDROGENO, HALOGENO, ALQUILO C1-C4 QUE PUEDE SER OPCIONALMENTE SUSTITUIDO POR HALOGENOS, ALCOXI C1-C4 QUE PUEDE SER OPCIONALMENTE SUSTITUIDO POR HALOGENOS; 2) R1 y R2 SON HIDROGENO o ALQUILO C1-C4; 3) X ES S, SO, SO2; 4) Z ES METILENO o ETILENO; DE PREFERENCIA: R1 y R2 SON HIDROGENOS; X ES AZUFRE; A ES 4-FLUORO; B ES HIDROGENO; Z ES ETILENO; DICHO COMPUESTO INHIBE LA ENZIMA LIPOXIGENASA, RESPONSABLE DE LA SINTESIS DE LEUCOTRIENOS, Y PUEDE SER UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, ALERGICAS Y CARDIOVASCULARESIT REFERS TO A COMPOUND OF FORMULA I WHERE: 1) A and B ARE HYDROGEN, HALOGEN, ALKYL C1-C4 THAT CAN BE OPTIONALLY REPLACED BY HALOGEN, ALCOXI C1-C4 THAT CAN BE OPTIONALLY REPLACED BY HALOGEN; 2) R1 and R2 ARE HYDROGEN or C1-C4 ALKYL; 3) X ES S, SO, SO2; 4) Z IS METHYLENE or ETHYLENE; OF PREFERENCE: R1 and R2 ARE HYDROGEN; X IS SULFUR; A IS 4-FLUORINE; B IS HYDROGEN; Z IS ETHYLENE; SAID COMPOUND INHIBITS THE LIPOXIGENASA ENZYME, RESPONSIBLE FOR THE SYNTHESIS OF LEUCOTRENE, AND MAY BE USEFUL IN THE TREATMENT OF INFLAMMATORY, ALLERGIC AND CARDIOVASCULAR DISEASES

PE1994256818A 1993-12-22 1994-12-12 Phenylthiophenyl cycloalkenyl hydroxyurea PE36395A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34561893 1993-12-22

Publications (1)

Publication Number Publication Date
PE36395A1 true PE36395A1 (en) 1995-11-07

Family

ID=18377822

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994256818A PE36395A1 (en) 1993-12-22 1994-12-12 Phenylthiophenyl cycloalkenyl hydroxyurea

Country Status (9)

Country Link
EP (1) EP0736006A1 (en)
JP (1) JP2756732B2 (en)
AU (1) AU1120795A (en)
CA (1) CA2178833A1 (en)
CO (1) CO4230016A1 (en)
FI (1) FI946007A (en)
IL (1) IL111994A0 (en)
PE (1) PE36395A1 (en)
WO (1) WO1995017379A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3007138B2 (en) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 Novel hydroxamic acid and N-hydroxyurea derivatives and compositions thereof
US5283361A (en) * 1991-04-23 1994-02-01 Eli Lilly And Company N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as lipoxygenase inhibitors
JPH05294921A (en) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd New phenyl-substituted cycloalkylurea derivative and composition

Also Published As

Publication number Publication date
IL111994A0 (en) 1995-03-15
EP0736006A1 (en) 1996-10-09
CO4230016A1 (en) 1995-10-19
CA2178833A1 (en) 1995-06-29
FI946007A (en) 1995-06-23
JP2756732B2 (en) 1998-05-25
FI946007A0 (en) 1994-12-21
WO1995017379A1 (en) 1995-06-29
AU1120795A (en) 1995-07-10
JPH09503226A (en) 1997-03-31

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal