PE20231562A1 - IMIDAZO[1,2-a]PYRIDINIL DERIVATIVES AS IRAQ4 INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASES - Google Patents
IMIDAZO[1,2-a]PYRIDINIL DERIVATIVES AS IRAQ4 INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASESInfo
- Publication number
- PE20231562A1 PE20231562A1 PE2023001950A PE2023001950A PE20231562A1 PE 20231562 A1 PE20231562 A1 PE 20231562A1 PE 2023001950 A PE2023001950 A PE 2023001950A PE 2023001950 A PE2023001950 A PE 2023001950A PE 20231562 A1 PE20231562 A1 PE 20231562A1
- Authority
- PE
- Peru
- Prior art keywords
- disease
- imidazo
- diseases
- treatment
- derivatives
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 101000977771 Homo sapiens Interleukin-1 receptor-associated kinase 4 Proteins 0.000 abstract 1
- 102100023533 Interleukin-1 receptor-associated kinase 4 Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- -1 imidazo[1,2-a]pyridinyl Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se refiere a un compuesto que se relaciona con derivados de imidazo[1,2-a]piridinilo de Formula (I) o una sal farmaceuticamente aceptable de este con capacidad de modular la actividad de IRAK4, donde: X es CH, CF o N; Y es CH o N; Z es el anillo A o -CH2-anilloA- , donde - indica el punto de conexion a R1; R1 es H, CN, etc.; R2 es cicloalquilo C3-6 o alquilo C1-4; R3, R4, R5, R6 y R7 se seleccionan cada uno independientemente de H, halo, CN, alquiloC1-4, etc; R8 es H o halo. La divulgacion proporciona ademas metodos para su preparacion, para su uso medico, en particular para su uso en el tratamiento y manejo de enfermedades o trastornos que incluyen enfermedad inflamatoria, enfermedad autoinmune, cancer, enfermedad cardiovascular, una enfermedad del sistema nervioso central, enfermedad de la piel, una enfermedad y afeccion oftalmica y una enfermedad de los huesos.Refers to a compound that is related to imidazo[1,2-a]pyridinyl derivatives of Formula (I) or a pharmaceutically acceptable salt thereof with the capacity to modulate the activity of IRAK4, where: X is CH, CF or N ; Y is CH or N; Z is ring A or -CH2-ringA-, where - indicates the connection point to R1; R1 is H, CN, etc.; R2 is C3-6 cycloalkyl or C1-4 alkyl; R3, R4, R5, R6 and R7 are each independently selected from H, halo, CN, C1-4alkyl, etc.; R8 is H or halo. The disclosure further provides methods for its preparation, for its medical use, in particular for its use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, the skin, an ophthalmic disease and condition, and a bone disease.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062128964P | 2020-12-22 | 2020-12-22 | |
| PCT/US2021/064666 WO2022140425A1 (en) | 2020-12-22 | 2021-12-21 | Imidazo[1,2-a]pyridine derivatives as irak4 inhibitors and their use in the treatment of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20231562A1 true PE20231562A1 (en) | 2023-10-03 |
Family
ID=88792923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023001950A PE20231562A1 (en) | 2020-12-22 | 2021-12-21 | IMIDAZO[1,2-a]PYRIDINIL DERIVATIVES AS IRAQ4 INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASES |
Country Status (1)
| Country | Link |
|---|---|
| PE (1) | PE20231562A1 (en) |
-
2021
- 2021-12-21 PE PE2023001950A patent/PE20231562A1/en unknown
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