PE20230856A1 - CONDITIONALLY ACTIVATED RESTRICTED BINDING PROTEINS - Google Patents

CONDITIONALLY ACTIVATED RESTRICTED BINDING PROTEINS

Info

Publication number
PE20230856A1
PE20230856A1 PE2023000289A PE2023000289A PE20230856A1 PE 20230856 A1 PE20230856 A1 PE 20230856A1 PE 2023000289 A PE2023000289 A PE 2023000289A PE 2023000289 A PE2023000289 A PE 2023000289A PE 20230856 A1 PE20230856 A1 PE 20230856A1
Authority
PE
Peru
Prior art keywords
domain
restricted
pseudovariable
sdabd
variable
Prior art date
Application number
PE2023000289A
Other languages
Spanish (es)
Inventor
Robert B Dubridge
Tseng-Hui Timothy Chen
Patricia A Culp
Chad Michael May
Danielle Dettling
Jeremiah Degenhardt
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of PE20230856A1 publication Critical patent/PE20230856A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Abstract

Referida a una proteina de fusion que comprende, del extremo N al C: a) un primer sdABD que se une a HER2 (sdABD-HER2); b) un primer conector de dominio; c) un dominio Fv restringido que comprende: i) un primer dominio pesado variable que comprende una vhCDR1, vhCDR2 y vhCDR3; ii) un conector no escindible restringido (CNCL); y iii) un primer dominio ligero variable que comprende vlCDR1, vlCDR2 y vlCDR3; d) un segundo conector de dominio; e) un segundo sdABD-HER2; f) un conector escindible (CL); g) un dominio pseudo Fv restringido que comprende: i) un primer dominio ligero pseudovariable; ii) un conector no escindible (NCL); y iii) un primer dominio pesado pseudovariable; h) un tercer conector de dominio; y i) un tercer sdABD que se une a la seroalbumina humana (sdABDHSA); en el que el primer dominio pesado variable y el primer dominio ligero variable del dominio Fv restringido son capaces de unirse a CD3 humano pero el dominio pseudo Fv restringido no se une a CD3; el primer dominio pesado variable y el primer dominio ligero pseudovariable se asocian intramolecularmente para formar un Fv inactivo; y el primer dominio ligero variable y el primer dominio pesado pseudovariable se asocian intramolecularmente para formar un Fv inactivo.Referring to a fusion protein comprising, from N to C terminus: a) a first sdABD that binds to HER2 (sdABD-HER2); b) a first domain connector; c) a restricted Fv domain comprising: i) a first variable heavy domain comprising a vhCDR1, vhCDR2 and vhCDR3; ii) a restricted non-cleavable linker (CNCL); and iii) a first variable light domain comprising vlCDR1, vlCDR2 and vlCDR3; d) a second domain connector; e) a second sdABD-HER2; f) a cleavable linker (CL); g) a restricted pseudo Fv domain comprising: i) a first pseudovariable light domain; ii) a non-cleavable linker (NCL); and iii) a first pseudovariable heavy domain; h) a third domain connector; and i) a third sdABD that binds to human serum albumin (sdABDHSA); wherein the first variable heavy domain and the first variable light domain of the restricted Fv domain are capable of binding to human CD3 but the restricted pseudo Fv domain does not bind to CD3; the first variable heavy domain and the first pseudovariable light domain associate intramolecularly to form an inactive Fv; and the first variable light domain and the first pseudovariable heavy domain are associated intramolecularly to form an inactive Fv.

PE2023000289A 2020-08-17 2021-08-17 CONDITIONALLY ACTIVATED RESTRICTED BINDING PROTEINS PE20230856A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063066565P 2020-08-17 2020-08-17
PCT/US2021/046217 WO2022040128A2 (en) 2020-08-17 2021-08-17 Constrained conditionally activated binding proteins

Publications (1)

Publication Number Publication Date
PE20230856A1 true PE20230856A1 (en) 2023-05-29

Family

ID=77655705

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2023000289A PE20230856A1 (en) 2020-08-17 2021-08-17 CONDITIONALLY ACTIVATED RESTRICTED BINDING PROTEINS

Country Status (16)

Country Link
US (1) US20240026011A1 (en)
EP (1) EP4196503A2 (en)
JP (1) JP2023538366A (en)
KR (1) KR20230048146A (en)
CN (1) CN116419925A (en)
AR (1) AR123266A1 (en)
AU (1) AU2021329290A1 (en)
CA (1) CA3191431A1 (en)
CL (1) CL2023000477A1 (en)
CO (1) CO2023002164A2 (en)
EC (1) ECSP23018458A (en)
IL (1) IL300598A (en)
MX (1) MX2023002002A (en)
PE (1) PE20230856A1 (en)
TW (1) TW202214707A (en)
WO (1) WO2022040128A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202342521A (en) * 2022-02-23 2023-11-01 日商武田藥品工業股份有限公司 Conditionally bispecific binding proteins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102143506B1 (en) 2011-08-17 2020-08-12 글락소 그룹 리미티드 Modified proteins and peptides
MA43816A (en) 2016-03-08 2018-11-28 Maverick Therapeutics Inc INDUCTIBLE BINDING PROTEINS AND METHODS OF USE
PE20212205A1 (en) 2017-09-08 2021-11-18 Maverick Therapeutics Inc RESTRICTED CONDITIONALLY ACTIVATED BINDING PROTEINS
JP2022524338A (en) 2019-03-05 2022-05-02 武田薬品工業株式会社 Restrained and conditionally activated binding protein

Also Published As

Publication number Publication date
CL2023000477A1 (en) 2023-11-10
ECSP23018458A (en) 2023-04-28
CN116419925A (en) 2023-07-11
AR123266A1 (en) 2022-11-16
IL300598A (en) 2023-04-01
CA3191431A1 (en) 2022-02-24
JP2023538366A (en) 2023-09-07
EP4196503A2 (en) 2023-06-21
KR20230048146A (en) 2023-04-10
AU2021329290A1 (en) 2023-04-13
WO2022040128A2 (en) 2022-02-24
MX2023002002A (en) 2023-07-06
TW202214707A (en) 2022-04-16
WO2022040128A3 (en) 2022-04-07
CO2023002164A2 (en) 2023-03-07
US20240026011A1 (en) 2024-01-25

Similar Documents

Publication Publication Date Title
PE20212205A1 (en) RESTRICTED CONDITIONALLY ACTIVATED BINDING PROTEINS
PE20171324A1 (en) HETERODIMERIC ANTIBODIES THAT BIND CD3 AND TUMOR ANTIGENS
PE20200717A1 (en) ANTIBODY MOLECULES THAT BIND AND USES CD73
PE20161431A1 (en) BISPECIFIC ANTIBODIES THAT BIND CD38 AND CD3
AR085624A2 (en) P-CADERINE ANTIBODIES
PE20120549A1 (en) BISPECIFIC ANTIGEN BINDING PROTEINS
PE20120414A1 (en) ANTIGEN BINDING TETRAVALENT BISPECIFIC PROTEINS
PE20191463A1 (en) BISPECIFIC ANTIBODIES OF SPECIFIC JOINT PD1 AND LAG3
ECSP16070447A (en) ANTIBODY MOLECULES FOR TIM-3 AND THEIR USES
PE20211767A1 (en) ANTI-HLA-G ANTIBODIES, COMPOSITIONS INCLUDING ANTI-HLA-G ANTIBODIES AND METHODS OF USE OF ANTI-HLA-G ANTIBODIES
PE20141995A1 (en) MOLECULES WHICH ARE ANTIBODIES WITH SPECIFICITY FOR HUMAN OX 40
CL2015001895A1 (en) Antibodies that bind to tl1a and its uses
CL2018001596A1 (en) Bispecific antigen binding proteins of anti-tl1a / anti-tnf-a and their uses
EA200870555A1 (en) SLIP PROTEINS, THEIR APPLICATION AND METHODS OF THEIR PRODUCTION
PE20091269A1 (en) BINDING MOLECULES TO THE HUMAN OX40 RECEIVER
NZ607510A (en) Anti-il-1 beta antibodies and methods of use
CO6430469A2 (en) HUMANIZED ANTIBODIES THAT JOIN CD19 AND ITS USES
ES2670621T3 (en) Antibodies that bind to OX40 and its uses
PE20190514A1 (en) BISPECIFIC ANTIBODY TYPE UNION PROTEINS THAT SPECIFICALLY JOIN CD3 AND CD123
AR083672A1 (en) IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
EA201100527A1 (en) BIOLOGICAL PRODUCTS
AR078254A1 (en) IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
PE20120813A1 (en) DUAL VARIABLE DOMAIN IMMUNOGLOBULIN
CR11030A (en) UNION PROTEINS, INCLUDING ANTIBODIES, DERIVATIVES OF ANTIBODIES AND ANTIBODY FRAGMENTS, THAT SPECIFICALLY JOIN CD154 AND ITS USES
PE20110306A1 (en) HUMAN ANTIBODIES THAT JOIN LYMPHOCYTARY ACTIVATION GEN 3 (LAG-3)