PE20110426A1 - MODIFIED BOVINE G-CSF POLYPEPTIDES - Google Patents

MODIFIED BOVINE G-CSF POLYPEPTIDES

Info

Publication number
PE20110426A1
PE20110426A1 PE2011000065A PE2011000065A PE20110426A1 PE 20110426 A1 PE20110426 A1 PE 20110426A1 PE 2011000065 A PE2011000065 A PE 2011000065A PE 2011000065 A PE2011000065 A PE 2011000065A PE 20110426 A1 PE20110426 A1 PE 20110426A1
Authority
PE
Peru
Prior art keywords
polypeptide
csf
substitute
hydrazide
refers
Prior art date
Application number
PE2011000065A
Other languages
Spanish (es)
Inventor
Putnam Anna-Maria A Hays
Nick Knudsen
Thea Norman
Vadim Kraynov
Lillian Ho
Peter Connor Canning
Alan Koder
Original Assignee
Ambrx Inc
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc, Lilly Co Eli filed Critical Ambrx Inc
Publication of PE20110426A1 publication Critical patent/PE20110426A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]

Abstract

SE REFIERE A UN POLIPEPTIDO FACTOR ESTIMULANTE DE COLONIAS DE GRANULOCITOS BOVINO (bG-CSF) QUE COMPRENDE UNO O MAS AMINOACIDOS NO CODIFICADOS DE MANERA NATURAL QUE PRESENTAN UN GRUPO CARBONILO, AMINOOXILO, HIDRAZINA, HIDRAZIDA, SEMICARBAZIDA, AZIDA O ALQUINO, LOS CUALES ESTAN SUSTITUIDOS EN LOS RESIDUOS ANTES DE LA POSICION 1 COMO 3, 7, 33, 43, 58, 62, 67, 69, 99, 123, 124, 133, 134, 141, 166, ENTRE OTROS, DE LA SEQ ID NO: 1. DICHO POLIPEPTIDO ESTA UNIDO A UN LIGADOR BIFUNCIONAL, POLIMERO BIFUNCIONAL SOLUBLE EN AGUA COMO UN RESTO DE POLIETILENGLICOL, O UNA MOLECULA BIOLOGICAMENTE ACTIVA TAL COMO OTRO POLIPEPTIDO bG-CSF, ADEMAS EL POLIPEPTIDO COMPRENDE SUSTITUCION, ADICION O DELECION DE UNO O MAS AMINOACIDOS QUE AUMENTA LA RESISTENCIA A PROTEASAS DEL POLIPEPTIDO bG-CSF Y MODULA LA MADURACION DE LOS NEUTROFILOS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICAREFERS TO A POLYPEPTIDE COLONY-STIMULATING FACTOR OF BOVINE GRANULOCYTES (bG-CSF), INCLUDING ONE OR MORE NON-NATURALLY CODED AMINO ACIDS PRESENTING A CARBONYL, AMINOOXYL, LOSS-STAINLESS, HYDRAZINE, AZEMIDRAZIDE, SEMICAR-ALUMINUM, HYDRAZUIDE, HYDRAZIDE, HYDRAZIDE IN THE RESIDUES BEFORE POSITION 1 AS 3, 7, 33, 43, 58, 62, 67, 69, 99, 123, 124, 133, 134, 141, 166, AMONG OTHERS, OF SEQ ID NO: 1. SAID POLYPEPTIDE IS JOINED TO A BIFUNCTIONAL BINDER, BIFUNCTIONAL POLYMER SOLUBLE IN WATER AS A REST OF POLYETHYLENE GLYCOL, OR A BIOLOGICALLY ACTIVE MOLECULE SUCH AS ANOTHER POLYPEPTIDE bG-CSF, IN ADDITION TO THE POLYPEPTIDE OR SUBSTITUTE OF A SUBSTITUTE OTHER POLYPEPTIDE, UNDERSTANDING THE AMOUNT OF A SUBSTITUTE OTHER POLYPEPTIDE. RESISTANCE TO PROTEASES OF THE bG-CSF POLYPEPTIDE AND MODULATES THE MATURATION OF NEUTROPHILES. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION

PE2011000065A 2008-07-23 2009-07-22 MODIFIED BOVINE G-CSF POLYPEPTIDES PE20110426A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8313208P 2008-07-23 2008-07-23

Publications (1)

Publication Number Publication Date
PE20110426A1 true PE20110426A1 (en) 2011-07-01

Family

ID=41570844

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000065A PE20110426A1 (en) 2008-07-23 2009-07-22 MODIFIED BOVINE G-CSF POLYPEPTIDES

Country Status (23)

Country Link
US (3) US10138283B2 (en)
EP (2) EP3225248B1 (en)
JP (2) JP5680534B2 (en)
KR (1) KR101726884B1 (en)
CN (2) CN102159230A (en)
AR (1) AR072967A1 (en)
AU (1) AU2009274076C1 (en)
BR (1) BRPI0916515B8 (en)
CA (1) CA2729851C (en)
CL (1) CL2011000013A1 (en)
CO (1) CO6351745A2 (en)
EA (1) EA019968B1 (en)
ES (2) ES2963062T3 (en)
IL (1) IL210265A (en)
MX (1) MX2011000859A (en)
NZ (2) NZ591235A (en)
PA (1) PA8836801A1 (en)
PE (1) PE20110426A1 (en)
PL (2) PL2318029T3 (en)
PT (1) PT2318029T (en)
UA (2) UA118536C2 (en)
WO (1) WO2010011735A2 (en)
ZA (1) ZA201101166B (en)

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