PE20091524A1 - DERIVATIVES OF 2-AMINOPYRIMIDINE - Google Patents

DERIVATIVES OF 2-AMINOPYRIMIDINE

Info

Publication number
PE20091524A1
PE20091524A1 PE2008002136A PE2008002136A PE20091524A1 PE 20091524 A1 PE20091524 A1 PE 20091524A1 PE 2008002136 A PE2008002136 A PE 2008002136A PE 2008002136 A PE2008002136 A PE 2008002136A PE 20091524 A1 PE20091524 A1 PE 20091524A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrimidin
methylamine
amine
atoms
Prior art date
Application number
PE2008002136A
Other languages
Spanish (es)
Inventor
Gonzalez Elena Carceller
Bernado Marina Virgili
Via Josep Marti
Fuentes Eva Maria Medina
Original Assignee
Palau Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palau Pharma Sa filed Critical Palau Pharma Sa
Publication of PE20091524A1 publication Critical patent/PE20091524A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Abstract

REFERIDA A COMPUESTOS DERIVADOS DE 2-AMINO-PIRIMIDINA DE FORMULA (I), DONDE R1 ES (i) O (ii); R2 Y R3 FORMAN JUNTO AL ATOMO DE N AL QUE ESTAN UNIDOS, UN HETEROCICLICO SATURADO QUE PUEDE SER MONOCICLICO DE 4 A 7 ATOMOS, UN BICICLICO CON PUENTE DE 7 A 8 ATOMOS, UN BICICLICO FUSIONADO DE 8 A 12 ATOMOS, ENTRE OTROS; R4 Y R5 SON CADA UNO H, ALQUILO(C1-C4), ARILO, ENTRE OTROS; R6 ES ALQUILO(C1-C8), CICLOALQUILO(C3-C8)ALQUILO(C0-C6), Ar1-ALQUILO(C0-C4), ENTRE OTROS; Ar1 ES FENILO OPCIONALMENTE SUSTITUIDO POR HALO, CN, ALQUILO(C1-C4), ENTRE OTROS; R7 ES ANILLO HETEROCICLICO SATURADO MONOCILICO DE 4 A 7 ATOMOS QUE CONTIENE SOLO UN HETEROATOMO DE O, OPCIONALMENTE SUSTITUIDO POR HALO O ALQUILO(C1-C4); n ES 1, 2 O 3; p ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: 4-CICLOHEXILOXIMETIL-6-(3-(METILAMINO)AZETIDIN-1-IL)PIRIMIDIN-2-AMINA, 4-CICLOHEXILOXIMETIL-6-((3R)-3-(METILAMINO)PIRROLIDIN-1-IL)PIRIMIDIN-2-AMINA, 4-(CICLOPROPILMETOXIMETIL)-6-(3-(METILAMINO)AZETIDIN-1-IL)PIRIMIDIN-2-AMINA, ENTRE OTROS. SE REFIERE TAMBIEN A SU PROCEDIMIENTO DE PREPARACION Y A COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR H4 SIENDO UTILES PARA EL TRATAMIENTO DEL DOLOR, ENFERMEDADES ALERGICAS, ENFERMEDADES INMUNOLOGICAS, ENTRE OTROSREFERRING TO COMPOUNDS DERIVED FROM 2-AMINO-PYRIMIDINE FROM FORMULA (I), WHERE R1 IS (i) OR (ii); R2 AND R3 FORM, TOGETHER WITH THE N ATOM TO WHICH THEY ARE UNITED, A SATURATED HETEROCICLIC WHICH CAN BE MONO CYCLIC FROM 4 TO 7 ATOMS, A BICYCLE WITH A BRIDGE OF 7 TO 8 ATOMS, A FUSED BICYCLE OF 8 TO 12 ATOMS, AMONG OTHERS; R4 AND R5 ARE EACH H, ALKYL (C1-C4), ARYL, AMONG OTHERS; R6 IS ALKYL (C1-C8), CYCLOALKYL (C3-C8) ALKYL (C0-C6), Ar1-ALKYL (C0-C4), AMONG OTHERS; Ar1 IS PHENYL, OPTIONALLY SUBSTITUTED BY HALO, CN, ALKYL (C1-C4), AMONG OTHERS; R7 IS A 4 TO 7 ATOM SATURATED HETEROCYCLIC RING WITH ONLY ONE O HETEROATOM, OPTIONALLY REPLACED BY HALO OR ALKYL (C1-C4); n IS 1, 2 O 3; p IS 0, 1 OR 2. PREFERRED COMPOUNDS ARE: 4-CYCLOHEXYLOXIMETHYL-6- (3- (METHYLAMINE) AZETIDIN-1-IL) PYRIMIDIN-2-AMINE, 4-CYCLOHEXYLOXIMETHYL-6 - ((3R) -3- ( METHYLAMINE) PYRROLIDIN-1-IL) PYRIMIDIN-2-AMINE, 4- (CYCLOPROPYLMETOXIMETHYL) -6- (3- (METHYLAMINE) AZETHYDIN-1-IL) PYRIMIDIN-2-AMINE, AMONG OTHERS. IT ALSO REFERS TO ITS PREPARATION PROCEDURE AND TO THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. SAID COMPOUNDS ARE ANTAGONISTS OF THE H4 RECEPTOR, BEING USEFUL FOR THE TREATMENT OF PAIN, ALLERGIC DISEASES, IMMUNE DISEASES, AMONG OTHERS

PE2008002136A 2007-12-19 2008-12-18 DERIVATIVES OF 2-AMINOPYRIMIDINE PE20091524A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07382003 2007-12-19
US3423908P 2008-03-06 2008-03-06

Publications (1)

Publication Number Publication Date
PE20091524A1 true PE20091524A1 (en) 2009-09-25

Family

ID=39247222

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002136A PE20091524A1 (en) 2007-12-19 2008-12-18 DERIVATIVES OF 2-AMINOPYRIMIDINE

Country Status (4)

Country Link
AR (1) AR069813A1 (en)
PE (1) PE20091524A1 (en)
TW (1) TW200940529A (en)
WO (1) WO2009077608A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200904437A (en) 2007-02-14 2009-02-01 Janssen Pharmaceutica Nv 2-aminopyrimidine modulators of the histamine H4 receptor
WO2009018657A1 (en) 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
EA201000948A1 (en) 2007-12-19 2011-02-28 Бёрингер Ингельхайм Интернациональ Гмбх VIRAL POLYMERASE INHIBITORS
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
DK2493895T3 (en) 2009-10-29 2017-08-14 Vectura Ltd N-CONTRIBUTING HETEROYEER DERIVATIVES AS JAK3 KINase INHIBITORS
JP5728024B2 (en) * 2009-12-22 2015-06-03 メルク・シャープ・エンド・ドーム・ベー・フェー Amino-heteroaryl derivatives as HCN blockers
MX345142B (en) 2009-12-23 2017-01-18 Palau Pharma Sa Aminoalkylpyrimidine derivatives as histamine h4 receptor antagonists.
DK2858647T3 (en) 2012-06-08 2018-08-20 Sensorion H4 RECEPTOR INHIBITORS FOR TINNITUS TREATMENT
CN103922928A (en) * 2013-10-31 2014-07-16 北京利和知信科技有限公司 Ring substituted ether acid ester compound suitable for preparing olefin polymerization catalyst
GB202005858D0 (en) * 2020-04-22 2020-06-03 Heptares Therapeutics Ltd H4 Antagonist compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1505064A1 (en) * 2003-08-05 2005-02-09 Bayer HealthCare AG 2-Aminopyrimidine derivatives
WO2005054239A1 (en) * 2003-12-05 2005-06-16 Bayer Healthcare Ag 2-aminopyrimidine derivatives
EP1928862A1 (en) * 2005-09-13 2008-06-11 Palau Pharma, S.A. 2-aminopyrimidine derivatives as modulators of the histamine h4 receptor activity
NL2000323C2 (en) * 2005-12-20 2007-11-20 Pfizer Ltd Pyrimidine derivatives.
US20100035863A1 (en) * 2006-09-12 2010-02-11 Ucb Pharma, S.A. 2 Amino-Pyrimidine Derivatives As H4 Receptor Antagonists, Processes For Preparing Them And Their Use In Pharmaceutical Compositions

Also Published As

Publication number Publication date
AR069813A1 (en) 2010-02-17
WO2009077608A1 (en) 2009-06-25
TW200940529A (en) 2009-10-01

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