PE20090978A1 - DERIVATIVES OF FURO {3,2-d} PYRIMIDINE - Google Patents

DERIVATIVES OF FURO {3,2-d} PYRIMIDINE

Info

Publication number
PE20090978A1
PE20090978A1 PE2008001844A PE2008001844A PE20090978A1 PE 20090978 A1 PE20090978 A1 PE 20090978A1 PE 2008001844 A PE2008001844 A PE 2008001844A PE 2008001844 A PE2008001844 A PE 2008001844A PE 20090978 A1 PE20090978 A1 PE 20090978A1
Authority
PE
Peru
Prior art keywords
pyrimidine
methylamine
furo
compounds
derivatives
Prior art date
Application number
PE2008001844A
Other languages
Spanish (es)
Inventor
Marina Virgili Bernado
Josep Marti Via
Fuentes Eva Maria Medina
Elena Carceller Gonzalez
Original Assignee
Palau Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palau Pharma Sa filed Critical Palau Pharma Sa
Publication of PE20090978A1 publication Critical patent/PE20090978A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A COMPUESTOS DERIVADOS FURO[3,2-d]PIRIMIDINA DE FORMULA (I) DONDE R1 ES H, NH2; R2 Y R3 FORMAN JUNTO CON EL ATOMO DE N 3-(METILAMINO)AZETIDIN-1-IL, PIPERAZIN-1-IL, (1,4-DIAZEPAN-1-IL), ENTRE OTROS; R4 ES H, ALQUILO C1-C4, ENTRE OTROS, DONDE R4 PUEDE ESTAR SITUADO EN CUALQUIER POSICION DISPONIBLE DEL ANILLO A; n ES 0-3. SON COMPUESTOS SELECCIONADOS: 4-[(3R)-3-(METILAMINO)PIRROLIDIN-1-IL]-6,7,8,9-TETRAHIDROBENZOFURO[3,2-d]PIRIMIDIN-2-AMINA; 4-[3-(METILAMINO)AZETIDIN-1-IL]-6,7,8,9-TETRAHIDROBENZOFURO[3,2-d]PIRIMIDINA; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR H4 DE LA HISTAMINA, UTILES EN EL TRATAMIENTO DE ENFERMEDADES ALERGICAS, INMUNOLOGICAS E INFLAMATORIAS Y DOLORREFERRING TO FURO [3,2-d] PYRIMIDINE DERIVATIVE COMPOUNDS OF FORMULA (I) WHERE R1 IS H, NH2; R2 AND R3 FORM TOGETHER WITH THE ATOM OF N 3- (METHYLAMINE) AZETIDIN-1-IL, PIPERAZIN-1-IL, (1,4-DIAZEPAN-1-IL), AMONG OTHERS; R4 IS H, C1-C4 RENTAL, AMONG OTHERS, WHERE R4 MAY BE LOCATED IN ANY POSITION AVAILABLE FROM RING A; n IS 0-3. SELECTED COMPOUNDS ARE: 4 - [(3R) -3- (METHYLAMINE) PYRROLIDIN-1-IL] -6,7,8,9-TETRAHIDROBENZOFURO [3,2-d] PYRIMIDIN-2-AMINE; 4- [3- (METHYLAMINE) AZETHYDIN-1-IL] -6,7,8,9-TETRAHYDROBENZOFURO [3,2-d] PYRIMIDINE; AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE ANTAGONISTS TO THE HISTAMINE H4 RECEPTOR, USEFUL IN THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES AND PAIN

PE2008001844A 2007-10-30 2008-10-28 DERIVATIVES OF FURO {3,2-d} PYRIMIDINE PE20090978A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07381071 2007-10-30
US1993708P 2008-01-09 2008-01-09

Publications (1)

Publication Number Publication Date
PE20090978A1 true PE20090978A1 (en) 2009-07-13

Family

ID=39217961

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001844A PE20090978A1 (en) 2007-10-30 2008-10-28 DERIVATIVES OF FURO {3,2-d} PYRIMIDINE

Country Status (4)

Country Link
AR (1) AR069113A1 (en)
PE (1) PE20090978A1 (en)
TW (1) TW200934783A (en)
WO (1) WO2009056551A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
CA2841113A1 (en) 2011-07-08 2013-01-17 Novartis Ag Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
JP6185574B2 (en) 2012-06-08 2017-08-23 センソリオン H4 receptor inhibitor for treating tinnitus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005303893A1 (en) * 2004-11-11 2006-05-18 Argenta Discovery Ltd Pyrimidine compounds as histamine modulators

Also Published As

Publication number Publication date
WO2009056551A1 (en) 2009-05-07
AR069113A1 (en) 2009-12-30
TW200934783A (en) 2009-08-16

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