PE20090963A1 - METHOD FOR THE PRODUCTION OF 2'-DEOXY-5-AZACITIDINE (DECITABIN) - Google Patents

METHOD FOR THE PRODUCTION OF 2'-DEOXY-5-AZACITIDINE (DECITABIN)

Info

Publication number
PE20090963A1
PE20090963A1 PE2008001743A PE2008001743A PE20090963A1 PE 20090963 A1 PE20090963 A1 PE 20090963A1 PE 2008001743 A PE2008001743 A PE 2008001743A PE 2008001743 A PE2008001743 A PE 2008001743A PE 20090963 A1 PE20090963 A1 PE 20090963A1
Authority
PE
Peru
Prior art keywords
decitabin
azacitidine
deoxy
production
formula
Prior art date
Application number
PE2008001743A
Other languages
Spanish (es)
Inventor
Norbert Kraut
Oliver Jungmann
Original Assignee
Cilag Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07019826A external-priority patent/EP2050757A1/en
Application filed by Cilag Ag filed Critical Cilag Ag
Publication of PE20090963A1 publication Critical patent/PE20090963A1/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE UN PROCESO DE OBTENCION DE 2'-DESOXI-5-AZACITIDINA (DECITABINA), QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DONADOR DE GLUCOSIDO DE FORMULA (I), DONDE R ES ALQUILCARBONILO C1-C6, FENILCARBONILO, BENCILCARBONILO SUSTITUIDOS O NO; R1 ES CLORO, TRICLOROMETIL IMIDATO, -S-METILO, ENTRE OTROS, CON UNA BASE SILILADA DE FORMULA (II), DONDE R2 ES UN GRUPO PROTECTOR TAL COMO TRIMETILSILILO (TMS); EN PRESENCIA DE UN CATALIZADOR TAL COMO TRIFLUOROMETAN-SULFONATO, PARA OBTENER DECITABINA. DICHO COMPUESTO TIENE ACTIVIDAD DESMETILANTE DEL ADN Y ES UTIL EN EL TRATAMIENTO DEL CANCERA PROCESS FOR OBTAINING 2'-DEOXY-5-AZACITIDINE (DECITABINE) IS REFERRED TO, WHICH INCLUDES: A) REACTING A GLUCOSIDE DONOR COMPOUND OF FORMULA (I), WHERE R IS C1-C6 ALKYLCARBONYL OR BENTIZYLBENYLBONYLBONYL NOT; R1 IS CHLORINE, TRICHLOROMETIL IMIDATE, -S-METHYL, AMONG OTHERS, WITH A SILILATED BASE OF FORMULA (II), WHERE R2 IS A PROTECTIVE GROUP SUCH AS TRIMETHYLSILIL (TMS); IN THE PRESENCE OF A CATALYST SUCH AS TRIFLUOROMETHANE-SULPHONATE, TO OBTAIN DECITABIN. SUCH COMPOUND HAS DNA DEMETILATING ACTIVITY AND IS USEFUL IN THE TREATMENT OF CANCER

PE2008001743A 2007-10-10 2008-10-09 METHOD FOR THE PRODUCTION OF 2'-DEOXY-5-AZACITIDINE (DECITABIN) PE20090963A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97886707P 2007-10-10 2007-10-10
EP07019826A EP2050757A1 (en) 2007-10-10 2007-10-10 Method of producing 2' -deoxy-5-azacytidine (Decitabine)

Publications (1)

Publication Number Publication Date
PE20090963A1 true PE20090963A1 (en) 2009-07-13

Family

ID=40972431

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001743A PE20090963A1 (en) 2007-10-10 2008-10-09 METHOD FOR THE PRODUCTION OF 2'-DEOXY-5-AZACITIDINE (DECITABIN)

Country Status (5)

Country Link
AR (1) AR068769A1 (en)
CL (1) CL2008003000A1 (en)
JO (1) JO3022B1 (en)
PE (1) PE20090963A1 (en)
TW (1) TWI445713B (en)

Also Published As

Publication number Publication date
JO3022B1 (en) 2016-09-05
TWI445713B (en) 2014-07-21
TW200936604A (en) 2009-09-01
AR068769A1 (en) 2009-12-02
CL2008003000A1 (en) 2009-10-16

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