PE20090895A1 - TRIAZOLE DERIVATIVES AS JAK QUINASE INHIBITORS - Google Patents

TRIAZOLE DERIVATIVES AS JAK QUINASE INHIBITORS

Info

Publication number
PE20090895A1
PE20090895A1 PE2008001287A PE2008001287A PE20090895A1 PE 20090895 A1 PE20090895 A1 PE 20090895A1 PE 2008001287 A PE2008001287 A PE 2008001287A PE 2008001287 A PE2008001287 A PE 2008001287A PE 20090895 A1 PE20090895 A1 PE 20090895A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrazole
alkenyl
methyl
jak
Prior art date
Application number
PE2008001287A
Other languages
Spanish (es)
Inventor
Lynsie Almeida
Brian Aquila
Claudio Edmundo Chuaqui
Huiping Guan
Shan Huang
Stephanos Ioannidis
Michelle Lamb
Bo Peng
Jie Shi
Mei Su
Quibin Su
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40304964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090895(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20090895A1 publication Critical patent/PE20090895A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

REFERIDO A UN COMPUESTO DERIVADO DE TRIAZOL DE FORMULA (I): DONDE EL ANILLO A ES HETEROCICLILO OPCIONALMENTE SUSTITUIDO SOBRE EL C CON UNO O MAS R2; EL ANILLO B ES SELECCIONADO DE CARBOCICLO Y HETEROCICLILO OPCIONALMENTE SUSTITUIDO SOBRE EL C CON UNO O MAS R4; X ES -O-, -NH- Y -S-; R1 ES HALO, -CN, ALQUILO(C1-C6), ENTRE OTROS; R2 ES -CN, ALQUILO(C1-C6), ALQUENILO(C2-C6), ENTRE OTROS; R3 ES ALQUILO(C1-C6), ALQUENILO(C2-C6); ALQUINILO(C2-C6), ENTRE OTROS; R4 ES ALQUILO(C1-C6), ALQUENILO (C2-C6), CARBOCILILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (S)-N2-(1-(5-FLUOROPIRIDIN-2-IL)ETIL)-N4-(5-METIL-1H-PIRAZOL-3-IL)-6-(4-METILPIPERAZIN-1-IL)-1,3,5-TRIAZINA-2,4-DIAMINA, (S)-N2-(1-(5-FLUOROPIRIMIDIN-2-IL)ETIL)N4-(5-METIL-1H-PIRAZOL-3-IL)-6-MORFOLIN-1,3,5-TRIAZINA-2,4-DIAMINA, 4-(1-(5-FLUOROPIRIDIN-2-IL)ETOXI)-N-(5-METIL-1H-PIRAZOL-3-IL)-6-MORFOLIN-1,3,5-TRIAZIN-2-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMULACION Y A UN METODO DE PREPARACION. DICHO COMPUESTO TIENE ACTIVIDAD INHIBITORIA DE JAK QUINASA Y ES UTIL EN EL TRATAMIENTO DE TRASTORNOS MIELOPROLIFERATIVOS Y EL CANCERREFERRING TO A COMPOUND DERIVED FROM TRIAZOLE OF FORMULA (I): WHERE THE RING A IS HETEROCYCLYL OPTIONALLY SUBSTITUTED ON THE C WITH ONE OR MORE R2; RING B IS SELECTED FROM CARBOCYCLE AND HETEROCYCLYL OPTIONALLY SUBSTITUTED ON C WITH ONE OR MORE R4; X IS -O-, -NH- AND -S-; R1 IS HALO, -CN, (C1-C6) ALKYL, AMONG OTHERS; R2 IS -CN, ALKYL (C1-C6), ALKENYL (C2-C6), AMONG OTHERS; R3 IS ALKYL (C1-C6), ALKENYL (C2-C6); ALKINYL (C2-C6), AMONG OTHERS; R4 IS ALKYL (C1-C6), ALKENYL (C2-C6), CARBOCILYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (S) -N2- (1- (5-FLUOROPYRIDIN-2-IL) ETHYL) -N4- (5-METHYL-1H-PYRAZOLE-3-IL) -6- (4-METHYLPIPERAZIN-1- IL) -1,3,5-TRIAZINE-2,4-DIAMINE, (S) -N2- (1- (5-FLUOROPYRIMIDIN-2-IL) ETHYL) N4- (5-METHYL-1H-PYRAZOLE-3- IL) -6-MORPHOLIN-1,3,5-TRIAZINE-2,4-DIAMINE, 4- (1- (5-FLUOROPYRIDIN-2-IL) ETHOXY) -N- (5-METHYL-1H-PYRAZOLE-3 -IL) -6-MORFOLIN-1,3,5-TRIAZIN-2-AMINE, AMONG OTHERS. IT ALSO REFERS TO A FORMULATION AND A METHOD OF PREPARATION. SAID COMPOUND HAS JAK KINASE INHIBITORY ACTIVITY AND IS USEFUL IN THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS AND CANCER

PE2008001287A 2007-07-31 2008-07-31 TRIAZOLE DERIVATIVES AS JAK QUINASE INHIBITORS PE20090895A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95315807P 2007-07-31 2007-07-31

Publications (1)

Publication Number Publication Date
PE20090895A1 true PE20090895A1 (en) 2009-08-08

Family

ID=40304964

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001287A PE20090895A1 (en) 2007-07-31 2008-07-31 TRIAZOLE DERIVATIVES AS JAK QUINASE INHIBITORS

Country Status (6)

Country Link
AR (1) AR069899A1 (en)
CL (1) CL2008002243A1 (en)
PE (1) PE20090895A1 (en)
TW (1) TW200906818A (en)
UY (1) UY31254A1 (en)
WO (1) WO2009016410A2 (en)

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WO2010105243A1 (en) 2009-03-13 2010-09-16 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
WO2010144338A1 (en) * 2009-06-08 2010-12-16 Abraxis Bioscience, Llc Triazine derivatives and their therapeutical applications
EP2440053A4 (en) * 2009-06-09 2012-10-31 California Capital Equity Llc Benzyl substituted triazine derivatives and their therapeutical applications
NZ597379A (en) 2009-06-29 2014-04-30 Agios Pharmaceuticals Inc Therapeutic compounds and compositions
CA2793835C (en) 2009-10-21 2021-07-20 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
HUE039269T2 (en) 2011-05-03 2018-12-28 Agios Pharmaceuticals Inc Pyruvate kinase activators for use in therapy
CN102827073A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Therapeutically active compositions and application methods thereof
CN102827170A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Active treatment compositions and use method thereof
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
AR091858A1 (en) * 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc CISTATIONIN-g-LIASA INHIBITORS (CSE)
MX365747B (en) 2012-10-15 2019-06-12 Agios Pharmaceuticals Inc Therapeutic compounds and compositions.
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
WO2015003355A2 (en) * 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
CN105517996B (en) * 2013-07-11 2019-03-26 安吉奥斯医药品有限公司 Therapeutical active compound and its application method
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US10376510B2 (en) 2013-07-11 2019-08-13 Agios Pharmaceuticals, Inc. 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
KR20220070066A (en) 2014-03-14 2022-05-27 아지오스 파마슈티컬스 아이엔씨. Pharmaceutical compositions of therapeutically active compounds
KR102542097B1 (en) 2015-01-16 2023-06-09 바이엘 크롭사이언스 악티엔게젤샤프트 Method for preparing 4-cyanopiperidine hydrochloride
SI3307271T1 (en) 2015-06-11 2023-11-30 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators
BR122024000250A2 (en) 2015-10-15 2024-02-27 Les Laboratoires Servier USE OF A MUTANT ISOCITRATE 1 (IDH1) DEHYDROGENASE INHIBITOR AND A DNA DEMETHYLATING AGENT
UA123401C2 (en) 2015-10-15 2021-03-31 Аджиос Фармасьютікалз, Інк. Combination therapy for treating malignancies
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
WO2019245910A1 (en) * 2018-06-22 2019-12-26 Aduro Biotech, Inc. Triazine compounds and uses thereof
CN109020951B (en) * 2018-08-24 2020-06-02 大连理工大学 Naphthalimide derivative containing trisubstituted cyanuric chloride and synthesis method and application thereof
CN111454214B (en) * 2020-05-27 2023-04-07 龙曦宁（上海）医药科技有限公司 Synthetic method of 2-methoxy-1-pyrimidineethylamine hydrochloride

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2422377C (en) * 2000-09-15 2010-04-13 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
EP1345922B1 (en) * 2000-12-21 2006-05-31 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2003078426A1 (en) * 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Azolylaminoazine as inhibitors of protein kinases
EP1899323A2 (en) * 2005-05-16 2008-03-19 AstraZeneca AB Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
DK1945631T3 (en) * 2005-10-28 2012-10-22 Astrazeneca Ab 4- (3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES USED AS TYROSINKINASE INHIBITORS FOR CANCER TREATMENT

Also Published As

Publication number Publication date
TW200906818A (en) 2009-02-16
CL2008002243A1 (en) 2009-08-21
UY31254A1 (en) 2009-04-30
WO2009016410A3 (en) 2009-07-02
WO2009016410A2 (en) 2009-02-05
AR069899A1 (en) 2010-03-03

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