PE20080689A1 - KINASE INHIBITORS AMINE DERIVATIVES - Google Patents

KINASE INHIBITORS AMINE DERIVATIVES

Info

Publication number
PE20080689A1
PE20080689A1 PE2007000962A PE2007000962A PE20080689A1 PE 20080689 A1 PE20080689 A1 PE 20080689A1 PE 2007000962 A PE2007000962 A PE 2007000962A PE 2007000962 A PE2007000962 A PE 2007000962A PE 20080689 A1 PE20080689 A1 PE 20080689A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
amine
pyrrolo
pyrrolidin
Prior art date
Application number
PE2007000962A
Other languages
Spanish (es)
Inventor
Matthew Stephen Corbett
Goss Stryker Kauffman
Kevin Daniel Freeman-Cook
Blaise Scott Lippa
Michael Joseph Luzzio
Joel Morris
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20080689A1 publication Critical patent/PE20080689A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Abstract

REFERIDA A UN DERIVADO DE AMINA DE FORMULA (I), DONDE A ES UN BICICLO FUSIONADO; u ES UN ENTERO DE 0 A 3; V ES N O CR7; W Y X SON N O CR8; Y ES CH, N O NH; Z ES CH O N; D Y E SON C O N; L ES -(CR3R4)m- O C(O); m ES UN ENTERO DE 1 A 6; R1 Y R2 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C10, CICLOALQUENILO C5-C10, ENTRE OTROS; R3 Y R4 SON H, ALQUILO C1-C6, CF3; R5 ES OR13, NR14R15, NR11C(O)R10, ENTRE OTROS; R6 ES ALQUILO C1-C6 O CICLOALQUILO C3-C10; R7 ES HALOGENO, OH, CF3, ENTRE OTROS; R8 ES H, HALO, CN, OH O ALQUILO C1-C6; R10 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R11 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R13 ES ALQUILO C1-C6, CICLOALQUILO C3-C10, CICLOALQUENILO C5-C10, ENTRE OTROS; R14 ES H, CF3, ALQUILO C1-C6, ENTRE OTROS; R15 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3S)-3-{[(4-CLOROFENIL9AMINO]METIL}-1-(5-METIL-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)PIRROLIDIN-3-AMINA, 3-({[2-FLUORO-3-(TRIFLUOROMETIL)FENIL]AMINO}METIL)-1-(5-METIL-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)PIRROLIDIN-3-AMINA, (3S)-1-(5-METIL-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-3-{[3-(TRIFLUOROMETIL)FENIL]AMINO}METIL)PIRROLIDIN-3-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE QUINASA AKT Y/O P70S6K1 Y SON UTILES EN EL TRATAMIENTO DE CELULAS CANCEROSASREFERRED TO AN AMINE DERIVATIVE OF FORMULA (I), WHERE A IS A FUSED BIKE; u IS AN INTEGER FROM 0 TO 3; V IS NO CR7; W AND X ARE NO CR8; Y IS CH, N O NH; Z IS CH O N; D AND E ARE C O N; L ES - (CR3R4) m- O C (O); m IS AN INTEGER FROM 1 TO 6; R1 AND R2 ARE H, C1-C6 ALKYL, C3-C10 CYCLOALKYL, C5-C10 CYCLOALKENYL, AMONG OTHERS; R3 AND R4 ARE H, C1-C6 ALKYL, CF3; R5 IS OR13, NR14R15, NR11C (O) R10, AMONG OTHERS; R6 IS C1-C6 ALKYL OR C3-C10 CYCLOALKYL; R7 IS HALOGEN, OH, CF3, AMONG OTHERS; R8 IS H, HALO, CN, OH OR C1-C6 ALKYL; R10 IS H, C1-C6 ALKYL, C2-C6 ALKYL, AMONG OTHERS; R11 IS H, C1-C6 ALKYL, C2-C6 ALKYL, AMONG OTHERS; R13 IS C1-C6 ALKYL, C3-C10 CYCLOALKYL, C5-C10 CYCLOALKENYL, AMONG OTHERS; R14 IS H, CF3, C1-C6 ALKYL, AMONG OTHERS; R15 IS C1-C6 ALKYL, C2-C6 ALKYL, C2-C6 ALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (3S) -3 - {[(4-CHLOROPHENYL9AMINE] METHYL} -1- (5-METHYL-7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL) PYRROLIDIN-3-AMINE, 3 - ({[2-FLUORO-3- (TRIFLUOROMETIL) PHENYL] AMINO} METHYL) -1- (5-METHYL-7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL) PYRROLIDIN-3-AMINE, ( 3S) -1- (5-METHYL-7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL) -3 - {[3- (TRIFLUOROMETHYL) PHENYL] AMINO} METHYL) PYRROLIDIN-3-AMINE, AMONG OTHERS . IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF KINASE AKT AND / OR P70S6K1 AND ARE USEFUL IN THE TREATMENT OF CANCER CELLS

PE2007000962A 2006-07-26 2007-07-25 KINASE INHIBITORS AMINE DERIVATIVES PE20080689A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82044106P 2006-07-26 2006-07-26

Publications (1)

Publication Number Publication Date
PE20080689A1 true PE20080689A1 (en) 2008-06-14

Family

ID=38963178

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000962A PE20080689A1 (en) 2006-07-26 2007-07-25 KINASE INHIBITORS AMINE DERIVATIVES

Country Status (7)

Country Link
AR (1) AR062050A1 (en)
CL (1) CL2007002188A1 (en)
GT (1) GT200700062A (en)
PE (1) PE20080689A1 (en)
TW (1) TW200817408A (en)
UY (1) UY30499A1 (en)
WO (1) WO2008012635A2 (en)

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DE602007011628D1 (en) 2006-07-06 2011-02-10 Array Biopharma Inc DIHYDROFUROPYRIMIDINES AS ACT PROTEIN KINASE INHIBITORS
WO2008006039A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA99284C2 (en) 2007-05-11 2012-08-10 Елі Ліллі Енд Компані P70 s6 kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
EP2173723B3 (en) 2007-07-05 2014-11-19 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CA2692502C (en) 2007-07-05 2016-03-01 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
CA2711614A1 (en) 2008-01-08 2009-07-16 Array Biopharma Inc. Pyrrolopyridines as kinase inhibitors
WO2009089459A1 (en) 2008-01-09 2009-07-16 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
ES2392014T3 (en) 2008-01-09 2012-12-03 Array Biopharma, Inc. Pyrazolopyridines as kinase inhibitors
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AR074072A1 (en) 2008-11-11 2010-12-22 Lilly Co Eli COMPOSITE OF IMIDAZOL -PIPERIDIN -PIRROL-PIRIMIDIN-6-ONA, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MULTIFORM GLIOBLASTOMA
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Also Published As

Publication number Publication date
TW200817408A (en) 2008-04-16
CL2007002188A1 (en) 2008-02-01
AR062050A1 (en) 2008-08-10
WO2008012635A2 (en) 2008-01-31
GT200700062A (en) 2008-08-08
WO2008012635A3 (en) 2008-05-08
UY30499A1 (en) 2008-02-29

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