PE20080183A1 - TRA COMBINATION THERAPIES - Google Patents

TRA COMBINATION THERAPIES

Info

Publication number
PE20080183A1
PE20080183A1 PE2007000416A PE2007000416A PE20080183A1 PE 20080183 A1 PE20080183 A1 PE 20080183A1 PE 2007000416 A PE2007000416 A PE 2007000416A PE 2007000416 A PE2007000416 A PE 2007000416A PE 20080183 A1 PE20080183 A1 PE 20080183A1
Authority
PE
Peru
Prior art keywords
refers
tra
receptor antagonist
combination therapies
receptor
Prior art date
Application number
PE2007000416A
Other languages
Spanish (es)
Inventor
Enrico P Veltri
William J Greenlee
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38458156&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080183(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20080183A1 publication Critical patent/PE20080183A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN ANTAGONISTA RECEPTOR DE TROMBINA Y UN AGENTE CARDIOVASCULAR SELECCIONADO DE BLOQUEDORES DE CANALES DE CALCIO TAL COMO AMLODIPINA, DILTIAZEM, VERAPAMIL, ENTRE OTROS, ESTATINAS TALES COMO FLUVASTATINA, LOVASTATINA, PRAVASTATINA, ENTRE OTROS, HEPARINAS DE BAJO PESO MOLECULAR SELECCIONADO DE DALTEPARINA, ARDEPARINA, ENOXAPARINA, ENTRE OTROS, ANTIARRITMICOS SELECCIONADOS DE DOFETILIDA, ATENOLOL, PROPANOLOL, ENTRE OTROS, BLOQUEDORES ADRENERGICOS, IECA, BLOQUEADOR DEL RECEPTOR ANGIOTENSINA II, ANTAGONISTA DE ENDOTELINA, ENTRE OTROS. UN ANTAGONISTA RECEPTOR DE TROMBINA ES A, B, C, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE SINDROMES CORONARIOS Y PREVENCION SECUNDARIA EN PACIENTES SUCEPTIBLES A EVENTOS CARDIOVASCULARESREFERS TO A PHARMACEUTICAL COMPOSITION THAT INCLUDES A TROMBIN RECEPTOR ANTAGONIST AND A CARDIOVASCULAR AGENT SELECTED FROM CALCIUM CHANNEL BLOCKERS SUCH AS AMLODIPINE, DILTIAZEM, VERAPAMIL, BETWEEN OTHERS, LOVASTRAIN OTHERS, STATUVASTINAS TALES SELECTED MOLECULAR WEIGHT OF DALTEPARIN, ARDEPARIN, ENOXAPARIN, AMONG OTHERS, SELECTED ANTIARRHYTHMICS OF DOFETILIDE, ATENOLOL, PROPANOLOL, AMONG OTHERS, ADRENERGIC BLOCKERS, ANGOTHETIC, RECEPTOR II BLOCKER. A THROMBINE RECEPTOR ANTAGONIST IS A, B, C, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE. SUCH COMPOSITION IS USEFUL IN THE TREATMENT OF CORONARY SYNDROMES AND SECONDARY PREVENTION IN PATIENTS SUBSEQUENT TO CARDIOVASCULAR EVENTS

PE2007000416A 2006-04-06 2007-04-04 TRA COMBINATION THERAPIES PE20080183A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79046906P 2006-04-06 2006-04-06
US80861106P 2006-05-26 2006-05-26
US80978506P 2006-05-31 2006-05-31
US83948406P 2006-08-23 2006-08-23
US83947406P 2006-08-23 2006-08-23

Publications (1)

Publication Number Publication Date
PE20080183A1 true PE20080183A1 (en) 2008-03-10

Family

ID=38458156

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000416A PE20080183A1 (en) 2006-04-06 2007-04-04 TRA COMBINATION THERAPIES

Country Status (11)

Country Link
EP (1) EP2001471A1 (en)
JP (1) JP2009532487A (en)
AR (1) AR060354A1 (en)
AU (1) AU2007235353A1 (en)
BR (1) BRPI0710840A2 (en)
CA (1) CA2648613A1 (en)
MX (1) MX2008012933A (en)
NO (1) NO20084677L (en)
PE (1) PE20080183A1 (en)
TW (1) TW200812619A (en)
WO (1) WO2007117621A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI367112B (en) * 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
UA99638C2 (en) * 2007-12-11 2012-09-10 Баер Шеринг Фарма Акциенгезельшафт Oxazolidinones for the treatment and/or prophylaxis of heart failure
BRPI0906395A2 (en) * 2008-01-11 2016-11-01 Eisai R&D Man Co Ltd pharmaceutical composition, use of at least one compound or a pharmacologically acceptable salt thereof, kit, and method for treating or ameliorating heart disease
WO2009124103A2 (en) * 2008-04-02 2009-10-08 Schering Corporation Combination therapies comprising par1 antagonists with par4 antagonists
WO2010144339A2 (en) * 2009-06-08 2010-12-16 Schering Corporation A thrombin receptor antagonist and clopidogrel fixed dose tablet
US20130183392A1 (en) * 2011-07-15 2013-07-18 Steven Moore Insect repellant and system
KR20140028971A (en) * 2012-08-31 2014-03-10 한미약품 주식회사 Bilayered tablet composite formulation of atorvastatin, irbesartan and magnesium carbonate
CN105125504A (en) * 2015-09-17 2015-12-09 青岛华之草医药科技有限公司 Composition granules of blood lipid-lowering drug pitavastatin calcium

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040192753A1 (en) * 2000-06-15 2004-09-30 Samuel Chackalamannil Methods of use of thrombin receptor antagonists
US7235567B2 (en) * 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
EP2065384B1 (en) * 2002-04-16 2011-01-05 Schering Corporation Tricyclic thrombin receptor antagonist
CA2567981C (en) * 2004-05-28 2010-08-31 Schering Corporation Constrained himbacine analogs as thrombin receptor antagonists
CA2582639A1 (en) * 2004-10-08 2006-04-20 Schering Corporation Thrombin receptor antagonists
CN101146781A (en) * 2005-03-31 2008-03-19 先灵公司 Spirocyclic thrombin receptor antagonists
JP2009521458A (en) * 2005-12-22 2009-06-04 シェーリング コーポレイション Oxazoloisoquinoline derivatives as thrombin receptor antagonists
WO2007075964A2 (en) * 2005-12-22 2007-07-05 Schering Corporation Thrombin receptor antagonists as prophylaxis to complications from cardiopulmonary surgery

Also Published As

Publication number Publication date
WO2007117621A1 (en) 2007-10-18
NO20084677L (en) 2008-11-05
EP2001471A1 (en) 2008-12-17
JP2009532487A (en) 2009-09-10
CA2648613A1 (en) 2007-10-18
BRPI0710840A2 (en) 2011-08-23
AR060354A1 (en) 2008-06-11
MX2008012933A (en) 2008-10-15
AU2007235353A1 (en) 2007-10-18
TW200812619A (en) 2008-03-16

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